Chitosan Composite Biomaterials for Bone Tissue Engineering—a Review

Fourie, Jaundrie; Preez, Louis Du; Taute, Francois; Beer, Deon de

doi:10.1007/s40883-020-00187-7

Cited by 33 publications

(25 citation statements)

References 231 publications

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“…In addition, BGMs both protect the chitosan polymer from enzymatic degradation and neutralize acidification caused by chitosan degradation. This allows the scaffold to last longer and provides for better ingrowth of the bone and eventual formation of hard tissue [ 30 , 31 ]. There is an increasing clinical need for injectable biomaterials.…”

Section: Resultsmentioning

confidence: 99%

The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels

et al. 2021

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Bone defects can occur from many causes, including disease or trauma. Bone graft materials (BGMs) have been used to fill damaged areas for the reconstruction of diseased bone tissues since they are cost effective and readily available. However, BGMs quickly disperse around the tissue area, which ultimately leads to it migrating away from the defect after transplantation. We tested chitosan hydrogels as a useful carrier to hold BGMs in the transplantation area. In this study, we synthesized succinylated chitosan (SCS)-based hydrogels with a high decomposition rate and excellent biocompatibility. We confirmed that BGMs were well distributed inside the SCS hydrogel. The SCS-B hydrogel showed a decrease in mechanical properties, such as compressive strength and Young’s modulus, as the succinylation rate increased. SCS-B hydrogels also exhibited a high cell growth rate and bone differentiation rate. Moreover, the in vivo results showed that the SCS hydrogel resorbed into the surrounding tissues while maintaining the BGMs in the transplantation area for up to 6 weeks. These data support the idea that SCS hydrogel can be useful as a bioactive drug carrier for a broad range of biomedical applications.

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Section: Resultsmentioning

confidence: 99%

The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels

et al. 2021

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“…This composition mainly includes PLGA microspheres/nanoparticles loaded with growth factors/drugs that merged in implants containing chitosan to apply as a drug delivery system including bioactive molecule or local delivery. Moreover, to prepare scaffolds with porous structure, PLGA microspheres and chitosan have also been employed [ 77 , 78 , 79 ].…”

Section: Chitosan Composites Used In Implants and Dentistrymentioning

confidence: 99%

“…In the defect model of rabbit calvarial bone, the scaffolds with growth factors exhibited a favorable new bone manufacturing through enhancing regeneration of blood vessels and bone. As mentioned, these kinds of composite scaffolds are the most desirable scaffolds for bone tissue engineering [ 77 ].…”

Section: Chitosan Composites Used In Implants and Dentistrymentioning

confidence: 99%

Advancements in Fabrication and Application of Chitosan Composites in Implants and Dentistry: A Review

et al. 2022

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Chitosan is a biopolymer that is found in nature and is produced from chitin deacetylation. Chitosan has been studied thoroughly for multiple applications with an interdisciplinary approach. Antifungal antibacterial activities, mucoadhesion, non-toxicity, biodegradability, and biocompatibility are some of the unique characteristics of chitosan-based biomaterials. Moreover, chitosan is the only widely-used natural polysaccharide, and it is possible to chemically modify it for different applications and functions. In various fields, chitosan composite and compound manufacturing has acquired much interest in developing several promising products. Chitosan and its derivatives have gained attention universally in biomedical and pharmaceutical industries as a result of their desired characteristics. In the present mini-review, novel methods for preparing chitosan-containing materials for dental and implant engineering applications along with challenges and future perspectives are discussed.

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“…Various physicochemical characteristics have been observed in the three kinds of BG. Furthermore, the cellular response after being implanted in the human body is considerably influenced by various types of bulk and surface features that can be assigned to various BG classes [147].…”

Section: Soft Tissue Engineeringmentioning

confidence: 99%

A comprehensive review of bioactive glass: synthesis, ion substitution, application, challenges, and future perspectives

Sidhu

Borges²,

Yusuf

et al. 2021

jcc

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Bioactive glass (BG) and glass-ceramics (GC) have been employed for bone treatment tissue engineering applications. Bioactive glasses/bioglasses can be considered promising materials for bone-regenerative scaffolds fabrication, owing to the adaptable properties that make them appropriately be designed regarding their composition. The essential properties of bioactive glasses, enabling them to be applied in the engineering of bone tissue, can be explained as their potential to augment differentiation osteoprogenitor and cells of mesenchymal stem cells, enzyme activity, osteoblast adhesion, and revascularization. Much research is conducted for the development of phosphate glasses, borate/borosilicate BGs, and silicate. Accordingly, some metal-based glasses have also been surveyed for tissue engineering uses, technologically and biomedically. Many rare elements can also be incorporated in the network of the glass to achieve promising properties, possessing a positive influence on the associated angiogenesis and/or remodeling of bone. This review motivates for providing an overview toward bioactive glasses' general requirements, composition, production, and impact of ion substitution on bioactive glass. Attention has also been given to developments of bioactive glass applications in bone grafting, bone regeneration, drug delivery, dental implant coatings, antibacterial agents, and soft tissue engineering as well as challenges and future perspectives.

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Chitosan Composite Biomaterials for Bone Tissue Engineering—a Review

Cited by 33 publications

References 231 publications

The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels

The Effectiveness of Compartmentalized Bone Graft Sponges Made Using Complementary Bone Graft Materials and Succinylated Chitosan Hydrogels

Advancements in Fabrication and Application of Chitosan Composites in Implants and Dentistry: A Review

A comprehensive review of bioactive glass: synthesis, ion substitution, application, challenges, and future perspectives

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