Chitosan derivative composite nanoparticles as adjuvants enhance the cellular immune response via activation of the cGAS-STING pathway

Zhao, Zhi; Peng, Yue; Shi, Xueao; Zhao, Kai

doi:10.1016/j.ijpharm.2023.122847

Cited by 11 publications

(2 citation statements)

References 55 publications

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“…The results revealed a significant increase in the parasitization efficiency upon treatment with egg card sprinkled with chitosan nanopowder at a concentration of 0.2 mg. These findings are in agreement with previous studies that have reported the beneficial effects of chitosan nanopowder on various biological processes the efficiency may be attributed to the antimicrobial [ 37 ] and immunostimulatory properties of chitosan [ 56 ], which could enhance the host's immune response and reduce the risk of infection. The chitosan's efficacy in increasing parasitization efficiency can be attributed to its unique dual attributes.…”

Section: Discussionsupporting

confidence: 93%

Nature to Nurture: Chitosan nanopowder a natural carbohydrate polymer choice of egg parasitoid, Trichogramma Japonicum Ashmead

Bhagat,

Manzoor,

Mahajan

et al. 2023

Heliyon

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Section: Discussionsupporting

confidence: 93%

Nature to Nurture: Chitosan nanopowder a natural carbohydrate polymer choice of egg parasitoid, Trichogramma Japonicum Ashmead

Bhagat,

Manzoor,

Mahajan

et al. 2023

Heliyon

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“…Natural immunity is triggered primarily by damage-associated molecular patterns, which recognize pathogen-associated molecular patterns and pattern-recognition receptors that immunize the body against foreign pathogens, and is the first line of defense of natural immunity to protect the organism (Liu et al 2022 ; Lockhart et al 2022 ). The cGAS-STING signaling pathway is an important component of the natural immune system that has been discovered in recent years (Kwon and Bakhoum 2020 ; Zhao et al 2023 ). The cGAS is a novel cytoplasmic DNA receptor that recognizes abnormal DNA present in the cytoplasm produced by the organism or from outside and catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP, which binds as a second messenger and activates STING located in the endoplasmic reticulum (Zhang et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production

Wen,

Mu,

et al. 2023

Mol Med

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Background The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing number of studies have shown a strong link between abnormal activation of the cGAS-STING signaling pathway, a natural immune pathway mediated by the nucleic acid receptor cGAS, and the development and progression of autoimmune diseases. Therefore, it is important to identify an effective compound to specifically downregulate this pathway for disease. Methods The effect of Glabridin (Glab) was investigated in BMDMs and Peripheral blood mononuclear cell (PBMC) by establishing an in vitro model of cGAS-STING signaling pathway activation. An activation model stimulated by DMXAA was also established in mice to study the effect of Glab. On the other hand, we investigated the possible mechanism of action of Glab and the effect of Glab on Trex1-deficient mice. Results In this research, we report that Glab, a major component of licorice, specifically inhibits the cGAS-STING signaling pathway by inhibiting the level of type I interferon and inflammatory cytokines (IL-6 and TNF-α). In addition, Glab has a therapeutic effect on innate immune diseases caused by abnormal cytoplasmic DNA in Trex1-deficient mice. Mechanistically, Glab can specifically inhibit the interaction of STING with IRF3. Conclusion Glab is a specific inhibitor of the cGAS-STING signaling pathway and may be used in the clinical therapy of cGAS-STING pathway-mediated autoimmune diseases.

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Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy

Peres,

Matos,

Carreira

et al. 2024

Adv Funct Materials

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Breast cancer is the primary cause of cancer‐related death in women worldwide. Breast cancer subtypes are characterized by different gene expression patterns, which drive their prognostic factors and therapeutic options. Among them, triple‐negative breast cancer (TNBC) is one of the deadliest due to its aggressiveness, high rate of early recurrence and distant metastases, and limited therapeutic options. Despite the recent approval of monoclonal antibodies targeting programmed cell death protein 1 (PD‐1) or its ligand (PD‐L1) for the treatment of TNBC patients with a locally recurrent unresectable or metastatic tumor expressing PD‐L1, their response rate is very modest. It is reported that polymeric nanoparticle (NP)‐based cancer vaccines, co‐entrapping tumor‐associated antigens, Toll‐like receptor ligands and small interfering RNA (siRNA) targeting the expression of the immunosuppressive cytokine transforming growth factor (TGF)‐β1 by dendritic cells, sensitized TNBC to the agonist immune checkpoint OX40, inhibiting tumor growth and increasing overall survival. This anti‐tumor immune‐mediated effect is also observed in a luminal type of mammary cancer similar to human disease. Therefore, these synergistic anticancer effects of αOX40 and the antigen‐specific adaptive immunity induced by nanovaccine‐mediated TGF‐β silencing may guide the development of novel combination regimens able to improve the response rate to this aggressive tumor.

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Chitosan derivative composite nanoparticles as adjuvants enhance the cellular immune response via activation of the cGAS-STING pathway

Cited by 11 publications

References 55 publications

Nature to Nurture: Chitosan nanopowder a natural carbohydrate polymer choice of egg parasitoid, Trichogramma Japonicum Ashmead

Nature to Nurture: Chitosan nanopowder a natural carbohydrate polymer choice of egg parasitoid, Trichogramma Japonicum Ashmead

Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production

Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy

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