Chitosan/dialdehyde cellulose hydrogels with covalently anchored polypyrrole: Novel conductive, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory materials

Káčerová, Simona; Muchová, Monika; Doudová, Hana; Münster, Lukáš; Hanulíková, Barbora; Valášková, Kristýna; Kašpárková, Věra; Kuřitka, Ivo; Humpolíček, Petr; Víchová, Zdenka; Vašíček, Ondřej; Vícha, Jan

doi:10.1016/j.carbpol.2023.121640

Cited by 10 publications

(3 citation statements)

References 55 publications

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“…Hydrogels can be designed with a wide variety of characteristics to obtain biocompatible, stable, and bioresorbable polymeric matrices for applied biomedicine such as skin tissue engineering and wound management [72,73]. A crucial attribute of the use of hydrogels in wound healing is to ensure facile application, long-lasting adhesiveness, and the ability to be easily removed from human skin without causing any damage or leaving traces [74][75][76].…”

Section: Biomaterials-based Hydrogels In Skin Tissue Engineering Surg...mentioning

confidence: 99%

Biomaterials-Based Hydrogels for Therapeutic Applications

Chelu,

Magdalena Musuc

2024

Biomaterials in Microencapsulation

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Conventional therapeutic models based on the premise of a universal solution are facing a decrease in efficiency, emphasized by the large number of patients who show resistance or who do not respond positively to classic treatments. This perspective highlights the urgency for more precise approaches based on personalized treatments that are adaptable to the specific complexities and unique challenges faced by each patient. Hydrogels are biocompatible and biodegradable systems for well-controlled and targeted administration of therapeutic agents, being formed by 3D reticulated networks of water-soluble polymeric biomaterials, of natural, synthetic, or hybrid origin, with specific intrinsic and extrinsic properties. Due to the easily adjustable porous structure, hydrogels allow the encapsulation of macromolecular drugs, proteins, small molecules, cells, hormones, or growth factors in the gel matrix and their subsequent controlled release. The biomaterials used, the crosslinking methods, the design, and the functionalization strategies in obtaining hydrogels with improved properties are presented. The different possibilities of application are described transdermally, as dressing materials, oral, ocular, spray-able, or injectable, up to the intracellular level. This chapter extensively investigates the advances and unique advantages of hydrogels that enable effective, noninvasive, personalized treatments and provide greater patient comfort for a wide range of applications.

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Section: Biomaterials-based Hydrogels In Skin Tissue Engineering Surg...mentioning

confidence: 99%

Biomaterials-Based Hydrogels for Therapeutic Applications

Chelu,

Magdalena Musuc

2024

Biomaterials in Microencapsulation

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“…Natural polysaccharides have received significant attention for applications of biomedical carrier materials (e.g., hyaluronic acid (HA), sodium alginate, chitosan, cellulose and gelatin) due to multiple functional groups modified in various ways to change characteristics [ [14] , [15] , [16] , [17] , [18] ]. The chemical modification of functional groups is the key issue to control the structural properties of hydrogel, including stability, mechanical properties and biodegradation [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

In situ forming an injectable hyaluronic acid hydrogel for drug delivery and synergistic tumor therapy

Fan,

Liu,

Dong

et al. 2024

Heliyon

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“…In the field of biomaterial science, researchers are designing devices that, thanks to their properties (e.g., surface texture), modifications (e.g., physical, chemical) [8], or presence of antimicrobial agents, could be able to hinder the bacterial adhesion [6]. Prior to the functionalization of a biomaterial with antimicrobial agents, it is very important to demonstrate its biocompatibility [9][10][11][12] and to characterize its surface properties since they can influence the cell behavior [13,14] and differentiation [15]. Properties such as topography, roughness, pore size [13], which determine the biomaterial surface texture, can affect the protein adsorption and consequently the cell adhesion [12,13,16], so that studying them is fundamental.…”

Section: Introductionmentioning

confidence: 99%

Surface Properties of a Biocompatible Thermoplastic Polyurethane and Its Anti-Adhesive Effect against E. coli and S. aureus

Restivo,

Peluso,

Bloise

et al. 2024

JFB

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Thermoplastic polyurethane (TPU) is a polymer used in a variety of fields, including medical applications. Here, we aimed to verify if the brush and bar coater deposition techniques did not alter TPU properties. The topography of the TPU-modified surfaces was studied via AFM demonstrating no significant differences between brush and bar coater-modified surfaces, compared to the un-modified TPU (TPU Film). The effect of the surfaces on planktonic bacteria, evaluated by MTT assay, demonstrated their anti-adhesive effect on E. coli, while the bar coater significantly reduced staphylococcal planktonic adhesion and both bacterial biofilms compared to other samples. Interestingly, Pearson’s R coefficient analysis showed that Ra roughness and Haralick’s correlation feature were trend predictors for planktonic bacterial cells adhesion. The surface adhesion property was evaluated against NIH-3T3 murine fibroblasts by MTT and against human fibrinogen and human platelet-rich plasma by ELISA and LDH assay, respectively. An indirect cytotoxicity experiment against NIH-3T3 confirmed the biocompatibility of the TPUs. Overall, the results indicated that the deposition techniques did not alter the antibacterial and anti-adhesive surface properties of modified TPU compared to un-modified TPU, nor its bio- and hemocompatibility, confirming the suitability of TPU brush and bar coater films in the biomedical and pharmaceutical fields.

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Chitosan/dialdehyde cellulose hydrogels with covalently anchored polypyrrole: Novel conductive, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory materials

Cited by 10 publications

References 55 publications

Biomaterials-Based Hydrogels for Therapeutic Applications

Biomaterials-Based Hydrogels for Therapeutic Applications

In situ forming an injectable hyaluronic acid hydrogel for drug delivery and synergistic tumor therapy

Surface Properties of a Biocompatible Thermoplastic Polyurethane and Its Anti-Adhesive Effect against E. coli and S. aureus

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