Chitosan Encrusted Nonionic Surfactant Based Vesicular Formulation for Topical Administration of Ofloxacin

Maheshwari, Rahul; Thakur, Suchi; Singhal, Sarita; Patel, Ritesh; Tekade, Muktika; Tekade, RakeshK.

doi:10.1166/sam.2015.2245

Cited by 91 publications

(6 citation statements)

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“…Lately, niosomes have been considered as an efficient alternative to the liposomal drug carriers for the encapsulation of several biomolecules [123], including EA (table 3). They consist of vesicular colloidal drug carriers obtained by the selfassembly of non-ionic surfactants into vesicles, resembling the liposomes architecture [124].…”

Section: Encapsulation Within Liposomes and Niosomesmentioning

confidence: 99%

Strategies to improve ellagic acid bioavailability: from natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers

et al. 2020

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Strategies to improve ellagic acid bioavailability: from natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers To cite this article: Claudia Ceci et al 2020 Nanotechnology 31 382001 View the article online for updates and enhancements. Recent citations Rifabutin-Loaded Nanostructured Lipid Carriers as a Tool in Oral Anti-Mycobacterial Treatment of Crohn's Disease Helena Rouco et al

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Section: Encapsulation Within Liposomes and Niosomesmentioning

confidence: 99%

Strategies to improve ellagic acid bioavailability: from natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers

et al. 2020

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“…Also, in another study, encapsulated niosomes were encrusted with cationic chitosan for bioavailability improvement of antibiotics at the ophthalmic site, and the result of microbiological susceptibility tests revealed significantly higher anti-S. aureus activity of the synthesized formulation in comparison to Zenox™ (commercial eye drop). Overall, chitosan-coated niosomes exhibit enhanced interaction with bacteria due to increased surface electrical charge, making them a promising candidate for effectively treating bacterial conjunctivitis [74].…”

Section: Niosomes Delivery System Againstmentioning

confidence: 99%

Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance

Hemmati,

Chegini,

Arabestani

2023

Journal of Nanomaterials

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Staphylococcus aureus, a prominent bacterial pathogen, presents formidable medical challenges owing to its rapid development of resistance. The emergence of multidrug resistant (MDR) S. aureus strains has become a pressing concern for healthcare systems, driving researchers to explore novel therapeutic strategies for managing infections associated with this pathogen. In this pursuit, niosomal-based platforms have emerged as promising candidates to effectively target S. aureus and fight conventional antimicrobial resistance. Niosomes comprise a bilayer membrane formed by nonionic surfactants, which can encapsulate both hydrophilic and hydrophobic drugs. These nanoparticles are known as vesicular delivery systems and have many advantages, such as low cost, less toxicity, and more flexibility and stability. Moreover, niosomes, being an effective drug delivery system, can directly interact with the bacterial cell envelope, thereby enhancing the pharmacokinetic activities of drugs at infected sites. A niosome-based delivery system can effectively treat S. aureus infections by destroying the biofilm community, increasing intracellular targeting, and enhancing the antibacterial activity. The main mechanisms of action of niosomes against resistant S. aureus strains involve the ability to resist enzymatic degradation, controlled release profile, and targeted drug delivery, which can provide an effective dosage of antimicrobial agents at the site of actions. In addition, niosomes have the potential to transfer wide-spectrum materials from different classes of antibiotics to nonantibiotic antimicrobial agents, such as natural compounds, antimicrobial peptides, and metallic nanoparticles. The combination of polymeric materials in the structure of a niosomal formulation could improve their bioavailability, loading capacity, and therapeutic efficacy for different applications. Furthermore, niosomes could find application in photodynamic therapy, offering a promising alternative to conventional treatments for eradicating drug-resistant S. aureus isolates. Finally, niosomal nanocarriers can be developed for delivering the drugs to desired sites by different routes of administration and could be considered a powerful strategy for overcoming the therapeutic obstacles caused by MDR S. aureus.

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“…Thus, the drug delivery system, based on nanotechnology, is an answer to effective, targeted drug therapy for cancer diagnostics and therapy. A variety of nanotechnological approaches, such as nanoparticles [210], nanoemulsion [211], liposomes [212], niosomes [213], cubosomes [214], spanlastics [215], nanomicelles [216], and nanostructured lipid-carriers (NLC) [217] were used for the drug delivery system used. However, green synthesized metal nanoparticles are an effective strategy and a topic of pivotal importance in the application of drug delivery in therapeutic anticancer research.…”

Section: Applications and Limitations Of Aunps In Drug Delivery For Cancer Therapymentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Bharadwaj

Rabha

Pati³

et al. 2021

Molecules

137

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Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical and physical synthesis methods are a way to make AuNPs. In any case, the hunt for other more ecologically friendly and cost-effective large-scale technologies, such as environmentally friendly biological processes known as green synthesis, has been gaining interest by worldwide researchers. The international focus on green nanotechnology research has resulted in various nanomaterials being used in environmentally and physiologically acceptable applications. Several advantages over conventional physical and chemical synthesis (simple, one-step approach to synthesize, cost-effectiveness, energy efficiency, and biocompatibility) have drawn scientists’ attention to exploring the green synthesis of AuNPs by exploiting plants’ secondary metabolites. Biogenic approaches, mainly the plant-based synthesis of metal nanoparticles, have been chosen as the ideal strategy due to their environmental and in vivo safety, as well as their ease of synthesis. In this review, we reviewed the use of green synthesized AuNPs in the treatment of cancer by utilizing phytochemicals found in plant extracts. This article reviews plant-based methods for producing AuNPs, characterization methods of synthesized AuNPs, and discusses their physiochemical properties. This study also discusses recent breakthroughs and achievements in using green synthesized AuNPs in cancer treatment and different mechanisms of action, such as reactive oxygen species (ROS), mediated mitochondrial dysfunction and caspase activation, leading to apoptosis, etc., for their anticancer and cytotoxic effects. Understanding the mechanisms underlying AuNPs therapeutic efficacy will aid in developing personalized medicines and treatments for cancer as a potential cancer therapeutic strategy.

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Chitosan Encrusted Nonionic Surfactant Based Vesicular Formulation for Topical Administration of Ofloxacin

Cited by 91 publications

References 0 publications

Strategies to improve ellagic acid bioavailability: from natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers

Strategies to improve ellagic acid bioavailability: from natural or semisynthetic derivatives to nanotechnological approaches based on innovative carriers

Niosomal-Based Drug Delivery Platforms: A Promising Therapeutic Approach to Fight Staphylococcus aureus Drug Resistance

Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

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