Chitosan-functionalized graphene oxide as adjuvant in HEV P239 vaccine

Bai, Qianyu; Wang, Zhiwen; AN, Yina; Tian, Jianhui; Li, Zhilin; Yang, Yong; Dong, Yanjun; Chen, Mingyong; Liu, Tianlong

doi:10.1016/j.vaccine.2022.11.005

Cited by 9 publications

(3 citation statements)

References 50 publications

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“…A novel Hepatitis E virus (HEV) vaccine was created utilizing chitosan-modified nano-GO (GO-CS) as an adjuvant to support HEV antigen P239 protein (GO/CS/P239): GO/CS/P239 vaccine can promote immune cells to produce more IgG antibodies and cytokines, which were able to stimulate the organism to produce stronger cellular and humoral immunity [ 102 ].…”

Section: Cbm Vaccines and Immunotherapiesmentioning

confidence: 99%

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Papi

Spirito

Palmieri

2023

Carbon

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Section: Cbm Vaccines and Immunotherapiesmentioning

confidence: 99%

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Papi

Spirito

Palmieri

2023

Carbon

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“…It has been known to be used in anti-viral vaccine strategies that allow favorable interaction with the negatively charged virus. Immunotherapeutic effects of chitosan have been proved by inducing the production of cytokines (e.g., TNF-α, IL-1β, IFN-γ, and IL-10) which become a great indicator in the initiation of humoral immunity [ 25 , 26 , 27 ] and cellular immunity through stimulation of IgG antibodies [ 27 ]. Strong responses through both humoral and cellular immunity are crucial in developing a more efficient vaccine therapy.…”

Section: Animal-based Polymersmentioning

confidence: 99%

“…Some recent studies on chitosan adjuvants are as follows. Chitosan-modified as the carrier for adjuvant nanographene oxide (GO-CS) and P239 vaccine for hepatitis E virus (HEV) treatment [ 26 ]. Adding chitosan as an adjuvant improved graphene oxide toxicity and increased bioavailability.…”

Section: Animal-based Polymersmentioning

confidence: 99%

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Nordin

Husna

Ahmad

et al. 2023

Gels

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A key element in ensuring successful immunization is the efficient delivery of vaccines. However, poor immunogenicity and adverse inflammatory immunogenic reactions make the establishment of an efficient vaccine delivery method a challenging task. The delivery of vaccines has been performed via a variety of delivery methods, including natural-polymer-based carriers that are relatively biocompatible and have low toxicity. The incorporation of adjuvants or antigens into biomaterial-based immunizations has demonstrated better immune response than formulations that just contain the antigen. This system may enable antigen-mediated immunogenicity and shelter and transport the cargo vaccine or antigen to the appropriate target organ. In this regard, this work reviews the recent applications of natural polymer composites from different sources, such as animals, plants, and microbes, in vaccine delivery systems.

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Recent Advances in the Design and Structural/Functional Regulations of Biomolecule‐Reinforced Graphene Materials for Bone Tissue Engineering Applications

Li,

Zhao,

Wang

et al. 2024

Small Science

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Biomolecule‐reinforced graphene materials (Bio‐RGMs) have emerged as versatile matrices for biomedical and tissue engineering applications, owing to the combination of graphene‐based materials (GMs) with biomolecular components and their synergistic effects. In this review, an overview of the design, synthesis, structural/functional regulation, and bone engineering applications of various Bio‐RGMs is provided. Both covalent and noncovalent methods for conjugating biomolecules onto GMs, followed by an exploration of the structural diversity of Bio‐RGMs, ranging from 1D nanofibers to 2D membranes and 3D scaffolds/hydrogels/aerogels are discussed. Techniques such as electrospinning, self‐assembly, freeze‐drying, 3D printing, and templated synthesis are highlighted for their roles in designing and fabricating Bio‐RGM architectures. Additionally, specific properties and functions endowed to Bio‐RGMs by biomolecule conjugation, including biocompatibility, cytotoxicity, antibacterial activity, drug delivery ability, and fluorescent sensing are examined. Finally, recent advance is showcased in fabricating Bio‐RGMs for the bone tissue engineering applications of bone repair, regeneration, grafting, drug/cell delivery, and tumor inhibition, and further, the potential of Bio‐RGMs for preclinical applications is analyzed. It is believed that this review will deepen readers’ understanding of biomolecule–GM interactions and inspire the development of innovative Bio‐RGMs for advanced biomedical and tissue engineering applications.

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Chitosan-functionalized graphene oxide as adjuvant in HEV P239 vaccine

Cited by 9 publications

References 50 publications

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Nanotechnology in the COVID-19 era: Carbon-based nanomaterials as a promising solution

Natural Polymeric Composites Derived from Animals, Plants, and Microbes for Vaccine Delivery and Adjuvant Applications: A Review

Recent Advances in the Design and Structural/Functional Regulations of Biomolecule‐Reinforced Graphene Materials for Bone Tissue Engineering Applications

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