Chitosan hydrogels in 3D printing for biomedical applications

Rajabi, Mina; McConnell, Michelle; Cabral, Jaydee; Ali, M. Azam

doi:10.1016/j.carbpol.2021.117768

Cited by 245 publications

(138 citation statements)

References 103 publications

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“…Natural polymers are commonly used for biomedical purposes due to their high biocompatibility, biodegradability, and bioactivity [ 1 ]. In this sense, hydrogels from natural polymers for 3D bioprinting are gaining notoriety to produce scaffolds for applications such as wound dressing [ 2 ]. In particular, polysaccharides and proteins are applied as bioinks for 3D printing [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Zarandona

Bengoechea

Álvarez‐Castillo

et al. 2021

Gels

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Chitosan-pectin hydrogels were prepared, and their rheological properties were assessed in order to select the best system to develop scaffolds by 3D printing. Hydrogels showed a weak gel behavior with shear thinning flow properties, caused by the physical interactions formed between both polysaccharides, as observed by FTIR analysis. Since systems with high concentration of pectin showed aggregations, the system composed of 2 wt% chitosan and 2 wt% pectin (CHI2PEC2) was selected for 3D printing. 3D printed scaffolds showed good shape accuracy, and SEM and XRD analyses revealed a homogeneous and amorphous structure. Moreover, scaffolds were stable and kept their shape and size after a cycle of compression sweeps. Their integrity was also maintained after immersion in PBS at 37 °C, showing a high swelling capacity, suitable for exudate absorption in wound healing applications.

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Section: Introductionmentioning

confidence: 99%

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Zarandona

Bengoechea

Álvarez‐Castillo

et al. 2021

Gels

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“…Chitosan is an environmentally and eco-friendly polymer with multipurpose applications in various fields such as agriculture, cosmetology, food, paper, pharmacy and textile industries [64][65][66][67][68] and a potent agent for the removal of toxic pollutants [69,70]. It can be used in plant production systems as a single compound or combined with other polymers and elements [68,71].…”

Section: Practical Applications Of Chitosan On Vegetable Cropsmentioning

confidence: 99%

Sustainable Agriculture Systems in Vegetable Production Using Chitin and Chitosan as Plant Biostimulants

et al. 2021

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Chitin and chitosan are natural compounds that are biodegradable and nontoxic and have gained noticeable attention due to their effective contribution to increased yield and agro-environmental sustainability. Several effects have been reported for chitosan application in plants. Particularly, it can be used in plant defense systems against biological and environmental stress conditions and as a plant growth promoter—it can increase stomatal conductance and reduce transpiration or be applied as a coating material in seeds. Moreover, it can be effective in promoting chitinolytic microorganisms and prolonging storage life through post-harvest treatments, or benefit nutrient delivery to plants since it may prevent leaching and improve slow release of nutrients in fertilizers. Finally, it can remediate polluted soils through the removal of cationic and anionic heavy metals and the improvement of soil properties. On the other hand, chitin also has many beneficial effects such as plant growth promotion, improved plant nutrition and ability to modulate and improve plants’ resistance to abiotic and biotic stressors. The present review presents a literature overview regarding the effects of chitin, chitosan and derivatives on horticultural crops, highlighting their important role in modern sustainable crop production; the main limitations as well as the future prospects of applications of this particular biostimulant category are also presented.

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“…Chitosan is a natural biopolymer derived from the N -deacetylation of chitin, found on crustaceans’ shells, an insect’s exoskeleton, fungi cell walls, etc. Due to the exceptional biocompatibility, readily biodegradability, and the unique biological activity, chitosan has attracted sufficient attention in numerous biomedical applications [ 14 , 15 , 16 ]. Nevertheless, the production of cross-linked chitosan in neutral and alkaline conditions is limited for the poor solubility of chitosan.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

Zhang

Xiao-rui

et al. 2021

Marine Drugs

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Hydrogels, possessing high biocompatibility and adaptability to biological tissue, show great usability in medical applications. In this research, a series of novel cross-linked chitosan quaternary ammonium salt loading with gentamicin sulfate (CTMCSG) hydrogel films with different cross-linking degrees were successfully obtained by the reaction of chitosan quaternary ammonium salt (TMCS) and epichlorohydrin. Fourier transform infrared spectroscopy (FTIR), thermal analysis, and scanning electron microscope (SEM) were used to characterize the chemical structure and surface morphology of CTMCSG hydrogel films. The physicochemical property, gentamicin sulphate release behavior, cytotoxicity, and antibacterial activity of the CTMCSG against Escherichia coli and Staphylococcus aureus were determined. Experimental results demonstrated that CTMCSG hydrogel films exhibited good water stability, thermal stability, drug release capacity, as well as antibacterial property. The inhibition zone of CTMCSG hydrogel films against Escherichia coli and Staphylococcus aureus could be up to about 30 mm. Specifically, the increases in maximum decomposition temperature, mechanical property, water content, swelling degree, and a reduction in water vapor permeability of the hydrogel films were observed as the amount of the cross-linking agent increased. The results indicated that the CTMCSG-4 hydrogel film with an interesting physicochemical property, admirable antibacterial activity, and slight cytotoxicity showed the potential value as excellent antibacterial wound dressing.

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Chitosan hydrogels in 3D printing for biomedical applications

Cited by 245 publications

References 103 publications

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

3D Printed Chitosan-Pectin Hydrogels: From Rheological Characterization to Scaffold Development and Assessment

Sustainable Agriculture Systems in Vegetable Production Using Chitin and Chitosan as Plant Biostimulants

Preparation of Cross-linked Chitosan Quaternary Ammonium Salt Hydrogel Films Loading Drug of Gentamicin Sulfate for Antibacterial Wound Dressing

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