Chitosan–hydroxyapatite composites

Pighinelli, Luciano; Kucharska, Magdalena

doi:10.1016/j.carbpol.2012.06.004

Cited by 182 publications

(104 citation statements)

References 36 publications

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“…Therefore, this process must be carried out at pH 10 which is the optimum pH for the formation of HAp 20 .the formation of HAp was indicated by the presence of peaks at 2θ (ᵒ) angle of 31.98, 32.96, and 33.08 (Figure-3a). Morphological observation using SEM showed the formation of an agglomeration ( Figure-3b) and makes it difficult to determine the crystal size of the synthesized HAp, a similar result with synthesized HAp that the size of HAp crystal grains was reported to be around 150-300 nm 21,22 . The SEM also showed that the single particle of HAp crystals tend to form a round shape.…”

Section: Resultsmentioning

confidence: 81%

SYNTHESIS OF HAp-CHITOSAN-PVA COMPOSITE AS INJECTABLE BONE SUBSTITUTE MATERIAL

2017

Rasayan J Chem

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The main objective of this study is to synthesize a composite of hydroxyapatite (HAp)-chitosan-polyvinyl alcohol (PVA) and to evaluate its uses as bone filler. An injectable bone substitute (IBS) material is a suspension of bone filler which applied by injection to fill the gaps caused by osteoporosis. A hydroxyapatite used as the composite's component was synthesized from Tutut shell. The composite was made by mixing hydroxyapatite, chitosan and PVA to homogeneous followed by irradiation with gamma rays at 20 kGy. The composite was characterized by FTIR analysis, XRD, SEM, viscosity test, and cytotoxicity assay. The FTIR analysis showed the bond formation between hydroxyapatite and chitosan, which later formed cross linkages by the addition of PVA. The viscosity of the composite was 36dPa. The cytotoxicity assay (MTT assay) showed that the suspension is not toxic because the cell viability value was obtained at more than 50%. As a conclusion, the composite of HAp from tutut shell-chitosan-PVA is suitable to be used as an injectable bone substitute.

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Section: Resultsmentioning

confidence: 81%

SYNTHESIS OF HAp-CHITOSAN-PVA COMPOSITE AS INJECTABLE BONE SUBSTITUTE MATERIAL

2017

Rasayan J Chem

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“…Chitosan is obtained by the process of alkaline N-deacetylation of chitin. This polysaccharide derivative is currently being explored intensively by an increasing number of academic and industrial research groups (Suh and Matthew 2000;Muhd Julkapli et al 2011;Pighinelli (Rose et al 2014) and Kucharska 2013). Chitosan is a heteropolysaccharide consisting of linear β-1, 4-linked units (Fig.…”

Section: Chitosanmentioning

confidence: 99%

Biopolymers in Medical Implants

Bhatt

Jaffé

2015

Excipient Applications in Formulation Design and Drug Delivery

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Many researchers are exploring the potential use of biopolymers as implants in a wide range of applications ranging from replacements of bone to the regeneration of nerves. Biocompatibility, biodegradability and versatility are the properties which make these biopolymers materials of choice. Studies in biopolymer based implants (till date) indicate significant developments in terms of innovative strategies and design of implants to regenerate/repair a damaged tissue or organ. This chapter reviews the present state-of-art of biopolymers and their applications as medical implants. Several biopolymers namely poly (3-hydroxyalkanoates), collagen, gelatin, chitosan and hyaluronic acid are discussed in detail with reference to their applications in orthopaedics, ophthalmology, cardiology, otolaryngology and a few others.

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“…An appropriate medium for the cMWCNT and HA homogeneous dispersion is chitosan (CS). The nanotubes solubilization is favoured by the ability of chitosan to form covalent bonds with their carboxylated ends by the intermediary of its free amino-groups [25,26], while HA and chitosan interact by forming hydrogen-and coordination bonds [27,28]. Moreover, chitosan nanocomposites could be easily electrodeposited onto the surface of the electrochemical transducers, forming welladhering and uniform films with controllable and reproducible characteristics [29,30].…”

Section: Introductionmentioning

confidence: 99%

A nanotechnological approach to biosensors sensitivity improvement: application to organophosphorus pesticides determination

Stoytcheva

Zlatev

Montero

et al. 2017

Biotechnology & Biotechnological Equipment

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An electrochemical organophosphorus hydrolase-based sensor for direct organophosphorus pesticides determination was developed, analytically characterized and applied for paraoxon quantification. The biosensing platform was constructed by one-step electrodeposition onto the surface of a glassy carbon electrode of a bionanocomposite of chitosan with carbon nanotube (CNTs), hydroxyapatite (HA) and organophosphorus hydrolase. The sensor, optimized with respect to the CNTs and HA load, was characterized by the application of cyclic voltammetry and chronoamperometry. The limit of detection (LOD) was found to be as low as 0.1 mmol L ¡1 , the linear concentration range was extended up to 80 mmol L ¡1 , and the sensitivity was as high as 5.10 nA L mmol ¡1 . The sensor possesses enhanced sensitivity towards organophosphorus pesticides (OPs), because of the CNTs and the HA nanoparticles synergistic action.

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Chitosan–hydroxyapatite composites

Cited by 182 publications

References 36 publications

SYNTHESIS OF HAp-CHITOSAN-PVA COMPOSITE AS INJECTABLE BONE SUBSTITUTE MATERIAL

SYNTHESIS OF HAp-CHITOSAN-PVA COMPOSITE AS INJECTABLE BONE SUBSTITUTE MATERIAL

Biopolymers in Medical Implants

A nanotechnological approach to biosensors sensitivity improvement: application to organophosphorus pesticides determination

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