Chitosan–nanohydroxyapatite composites: Mechanical, thermal and bio-compatibility studies

Roy, Pratik; Sailaja, R. R. N.

doi:10.1016/j.ijbiomac.2014.11.023

Cited by 24 publications

(13 citation statements)

References 36 publications

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“…Various biocomposites of CaPO 4 with chitosan [ 234 , 403 , 425 , 436 , 453 , 462 , 499 , 581 , 582 , 583 , 584 , 585 , 586 , 587 , 588 , 589 , 590 , 591 , 618 , 638 , 643 , 746 , 747 , 748 , 749 , 750 , 751 , 752 , 753 , 754 , 755 , 756 , 757 ] and chitin [ 392 , 452 , 758 , 759 , 760 , 761 , 762 ] are also very popular. For example, a solution-based method was developed to combine HA powders with chitin, in which the ceramic particles were uniformly dispersed [ 758 , 759 ].…”

Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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The state-of-the-art on calcium orthophosphate (CaPO4)-containing biocomposites and hybrid biomaterials suitable for biomedical applications is presented. Since these types of biomaterials offer many significant and exciting possibilities for hard tissue regeneration, this subject belongs to a rapidly expanding area of biomedical research. Through the successful combinations of the desired properties of matrix materials with those of fillers (in such systems, CaPO4 might play either role), innovative bone graft biomaterials can be designed. Various types of CaPO4-based biocomposites and hybrid biomaterials those are either already in use or being investigated for biomedical applications are extensively discussed. Many different formulations in terms of the material constituents, fabrication technologies, structural and bioactive properties, as well as both in vitro and in vivo characteristics have been already proposed. Among the others, the nano-structurally controlled biocomposites, those containing nanodimensional compounds, biomimetically fabricated formulations with collagen, chitin and/or gelatin, as well as various functionally graded structures seem to be the most promising candidates for clinical applications. The specific advantages of using CaPO4-based biocomposites and hybrid biomaterials in the selected applications are highlighted. As the way from a laboratory to a hospital is a long one and the prospective biomedical candidates have to meet many different necessities, the critical issues and scientific challenges that require further research and development are also examined.

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Section: Biocomposites and Hybrid Biomaterials Containing Capo mentioning

confidence: 99%

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Dorozhkin¹

2015

JFB

131

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“…It would establish an interfacial bonding between the biomaterial and the tissues after implanting. The process of apatite formation on bioactive materials can be assessed, in‐vitro, by SBF uptake measurements 21‐23 . The surface OH groups of HA particles are highly reactive and they can readily make covalent linkages with a compatible polymer matrix.…”

Section: Introductionmentioning

confidence: 99%

Functional modification of silicone rubber through nano‐hydroxylapatite embedding

Bindu

Ananthapadmanabhan

2021

Polymers for Advanced Techs

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Silicone rubber (SR) has extensively been used for different industrial and biomedical applications, in view of its good elasticity, chemical inertness, and biocompatibility. However, cure inhibition features, poor mechanical properties, and hydrophobicity, often, limit the possible expansion of its spectrum of applications. The present work has been designed to address these issues by embedding a potential biocompatible filler, nano‐hydroxylapatite (n‐HA), within the SR matrix, through compression molding. The n‐HA particles were initially synthesized by a wet chemical method, and were subsequently introduced into SR quantitatively. The rheological features, compressive properties, simulated body fluid (SBF) uptake, bovine serum albumin (BSA) adsorption, blood compatibility, and cytocompatibility of n‐HA modified SR systems have been investigated. The change in rheological characteristics after n‐HA embedding within SR clearly indicated the favorable interactions between them, and a compatible functional existence under external stresses. The compressive strength, which is critical for the different applications of SR, has been found to be increased with an increase in n‐HA loading. In‐vitro mineralization studies using SBF showed the formation of apatite crystals on the surface of SR/n‐HA system indicating its biocompatibility. This has been confirmed by SEM and FTIR examinations. It has further been observed that the addition of n‐HA particles into SR matrix enhances the protein adsorption characteristics. The n‐HA embedded system exhibited excellent blood compatibility, which has been complemented through hemolysis (%) studies and thrombogenicity assay. The results indicate that the strategy of n‐HA embedding would do significant value addition to SR, and widen its scope in the industrial and biomedical sectors.

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“…To eliminate the limitations of the current therapies, bone tissue engineering (BTE) offers promising alternatives. With this regard, the three-dimensional (3D) porous scaffold with appropriate physical, mechanical, and biological properties has been utilized to aid and promote bone regeneration. − The mechanical properties such as compressive strength are vital for cellular interactions, as the scaffold needs to tolerate internal stress until bone tissue regeneration takes place …”

Section: Introductionmentioning

confidence: 99%

“…5−8 The mechanical properties such as compressive strength are vital for cellular interactions, as the scaffold needs to tolerate internal stress until bone tissue regeneration takes place. 9 Various materials, including metals, ceramics, polymers, and their composites, have been utilized in the fabrication of bone scaffolds. 5 Calcium phosphate (CaP) bioceramics have been widely used because of the excellent bioactivity, osteoconductivity, and compositional similarities to bone mineral.…”

Section: Introductionmentioning

confidence: 99%

Hydroxyethyl Chitosan-Reinforced Polyvinyl Alcohol/Biphasic Calcium Phosphate Hydrogels for Bone Regeneration

Nie

Deng

et al. 2020

ACS Omega

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Fabrication of reinforced scaffolds for bone regeneration remains a significant challenge. The weak mechanical properties of the chitosan (CS)-based composite scaffold hindered its further application in clinic. Here, to obtain hydroxyethyl CS (HECS), some hydrogen bonds of CS were replaced by hydroxyethyl groups. Then, HECS-reinforced polyvinyl alcohol (PVA)/biphasic calcium phosphate (BCP) nanoparticle hydrogel was fabricated via cycled freeze-thawing followed by an in vitro biomineralization treatment using a cell culture medium. The synthesized hydrogel had an interconnected porous structure with a uniform pore distribution. Compared to the CS/PVA/BCP hydrogel, the HECS/PVA/BCP hydrogels showed a thicker pore wall and had a compressive strength of up to 5–7 MPa. The biomineralized hydrogel possessed a better compressive strength and cytocompatibility compared to the untreated hydrogel, confirmed by CCK-8 analysis and fluorescence images. The modification of CS with hydroxyethyl groups and in vitro biomineralization were sufficient to improve the mechanical properties of the scaffold, and the HECS-reinforced PVA/BCP hydrogel was promising for bone tissue engineering applications.

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Chitosan–nanohydroxyapatite composites: Mechanical, thermal and bio-compatibility studies

Cited by 24 publications

References 36 publications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Calcium Orthophosphate-Containing Biocomposites and Hybrid Biomaterials for Biomedical Applications

Functional modification of silicone rubber through nano‐hydroxylapatite embedding

Hydroxyethyl Chitosan-Reinforced Polyvinyl Alcohol/Biphasic Calcium Phosphate Hydrogels for Bone Regeneration

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