Chitosan nanoparticles and based composites as a biocompatible vehicle for drug delivery: A review

Pathak, Rakshit; Bhatt, Shalini; Punetha, Vinay Deep; Punetha, Mayank

doi:10.1016/j.ijbiomac.2023.127369

Cited by 19 publications

(1 citation statement)

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“…CS, a kind of natural polymer, is extracted from the shells of crustaceans and possesses the desirable properties in biodegradability, biocompatibility and antimicrobial properties. CS and CS derivates have been largely used as matrix materials for bone regeneration [ 12 ] and drug loading and release carrier materials [ 13 ]. However, the insoluble nature of CS limits its further biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

An injectable magnesium-coordinated phosphate chitosan-based hydrogel loaded with vancomycin for antibacterial and osteogenesis in the treatment of osteomyelitis

Zhang,

Wang,

Qian

et al. 2024

Regenerative Biomaterials

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Microbial infections of bones, particularly after joint replacement surgery, are a common occurrence in clinical settings and often lead to osteomyelitis (OM). Unfortunately, current treatment approaches for OM are not satisfactory. To address this issue, this study focuses on the development and evaluation of an injectable magnesium oxide (MgO) nanoparticle-coordinated phosphocreatine-grafted chitosan hydrogel (CMPMg-VCM) loaded with varying amounts of vancomycin (VCM) for the treatment of OM. The results demonstrate that the loading of VCM does not affect the formation of the injectable hydrogel, and the MgO-incorporated hydrogel exhibits anti-swelling properties. The release of VCM from the hydrogel effectively kills staphylococcus aureus bacteria, with CMPMg-VCM (50) showing the highest antibacterial activity even after prolonged immersion in PBS solution for 12 days. Importantly, all the hydrogels are non-toxic to MC3T3-E1 cells and promote osteogenic differentiation through the early secretion of alkaline phosphatase and calcium nodule formation. Furthermore, in vivo experiments using a rat OM model reveal that the CMPMg-VCM hydrogel effectively kills and inhibits bacterial growth, while also protecting the infected bone from osteolysis. These beneficial properties are attributed to the burst release of VCM, which disrupts bacterial biofilm, as well as the release of Mg ions and hydroxyl by the degradation of MgO nanoparticles, which inhibits bacterial growth and prevents osteolysis. Overall, the CMPMg-VCM hydrogel exhibits promising potential for the treatment of microbial bone infections.

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Section: Introductionmentioning

confidence: 99%