Chitosan nanoparticles for daptomycin delivery in ocular treatment of bacterial endophthalmitis

Abstract

The obtained nanoparticles have suitable characteristics for ocular applications, arising as a promising solution for the topical administration of daptomycin to the eye.

Improvement of the antibacterial activity of daptomycin-loaded polymeric microparticles by Eudragit RL 100: An assessment by isothermal microcalorimetry

“…On the other hand, daptomycin encapsulation has not been thoroughly investigated in the research and clinical settings, literature being scarce on its association to particulate carriers (Silva et al, 2013).…”

“…Usually the antibacterial effect of encapsulated antibiotics has been studied mainly using agar diffusion or broth macro-and microdilution methods (Bhatta et al, 2012;Silva et al, 2013). Although these microbiological techniques are simple and routinely used, they present several disadvantages regarding the antibacterial effect assessment of antibiotic-loaded polymeric particles, such as variable diffusion of the antibiotics and the interaction with the paper disks (Dickert et al, 1981;Fuchs et al, 2001;Sader et al, 2006).…”

Chitosan: A Good Candidate for Sustained Release Ocular Drug Delivery Systems

“…The degree of incorporation varies between 80 and 97%. Total daptomycin release was achieved in 4 h. Incubation with lysozyme did not affect the integrity of nanoparticles [108].…”

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

“…It has dual roles as bactericidal agent and mucoadhesive material in nanoparticles. Chitosan nanoparticles were used to entrap daptomycin for Staphylococcus bacteria, including MRSA (Silva et al, 2015). The encapsulation percentage of daptomycin in nanocarriers was >80%.…”