Chitosan Nanoparticles Self-Assembled from Electrospun Composite Nanofibers

Yu, Deng Guang; Williams, G. D.; Yang, Jing; Wang, Xia

doi:10.4172/2165-8064.1000107

Cited by 2 publications

(4 citation statements)

References 35 publications

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“…Therefore, we mainly focus our discussion on the region 900-1300 cm −1 , where some vibrational bands typical for CS may present [12,[39][40][41][42][43]. Before moving to this discussion, it is worth noting that the carbonyl band (C=O), which can be seen clearly in Figure 6a, is gradually downshifted from its original position at 1661 cm −1 in sample A to 1557 cm −1 for sample E. This confirms the influence of intermolecular interactions (namely H-bonding) on the position of C=O band and was previously described in a number of papers [13,29,43,44] devoted to FTIR investigation of polymer fibre composites and blends. As was reported in earlier studies of different research groups [29,45,46], the H-bonding in complex polymers is considered to be strong if the carbonyl band position is located below 1661 cm −1 .…”

Section: Ftir Spectroscopysupporting

confidence: 86%

“…The content of chitosan incorporated in the fibres is very significant. This concentration of chitosan is higher than anything that has been reported in the previous literature when forming a blend with another polymer [13,57]. Chitosan and PVP presented un-altered features post-electrospinning.…”

Section: Discussionmentioning

confidence: 50%

“…The H-bonding with C=O groups in PVP can be formed by the -OH and -NH 2 groups from chitosan. In addition to H-bonding, CS and PVP may also interact with each other through electrostatic interactions between the negatively charged PVP oxygen atom (N + = C-O-) and the ionizable amino group of CS [13,34]. Further support for the effect of CS presence on CS/PVP fibre composite was obtained from considering the range of spectra of 2730-3100 cm −1 representing the CH and CH 2 stretching vibrations bands [26,28,35], see Figure 4a,b.…”

Section: Raman Analysismentioning

confidence: 99%

“…Chitosan and PVP were spun together at 50 ± 2 • C. Characterization techniques were used to show that chitosan and PVP were mixed on a molecular scale. IR spectra showed that secondorder hydrogen bonding and electrostatic interactions played a large role in promoting homogeneity [13].…”

Section: Introductionmentioning

confidence: 99%

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Electrospun Fibres of Chitosan/PVP for the Effective Chemotherapeutic Drug Delivery of 5-Fluorouracil

et al. 2021

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Electrospun nanofibrous mats consisting of chitosan (CS) and polyvinylpyrrolidone (PVP) were constructed. Tuning of solution and process parameters was performed and resulted in an electrospun system containing a 6:4 ratio of PVP:CS. This is a significant increase in the proportion of spun CS on the previously reported highest ratio PVP:CS blend. SEM analysis showed that the nanofibrous mats with 4 wt% CS/6 wt% PVP (sample E) comprised homogenous, uniform fibres with an average diameter of 0.569 μm. XPS analysis showed that the surface of the samples consisted of PVP. Raman and FTIR analysis revealed intermolecular interactions (via H-bonding) between PVP and CS. In FTIR spectra, the contribution of chitosan to CS/PVP complexes was shown by the downshift of the C=O band and by the linear increase in intensity of C-O stretching in CS. XPS analysis showed a smaller shift at the binding energy 531 eV, which relates to the amide of the acetylated functional groups. The obtained results demonstrate a sensitivity of Raman and FTIR tests to the presence of chitosan in PVP:CS blend. The chemotherapy drug 5-Fu was incorporated into the constructs and cell viability studies were performed. WST-8 viability assay showed that exposure of A549 human alveolar basal epithelial cells to 10 mg/mL 5-Fu loaded fibres was most effective at killing cells over 24 h. On the other hand, the constructs with loading of 1 mg/mL of drug were not efficient at killing A549 human alveolar basal epithelial cells. This study showed that CS/PVP/5-Fu constructs have potential in chemotherapeutic drug delivery systems.

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