Chitosan-Tripolyphosphate Nanoparticles Prepared by Ionic Gelation Improve the Antioxidant Activities of Astaxanthin in the In Vitro and In Vivo Model

Kim, Eun Suh; Baek, Youjin; Yoo, Hyun-Jae; Lee, Ji-Soo; Lee, Hyeon Gyu

doi:10.3390/antiox11030479

Cited by 31 publications

(20 citation statements)

References 49 publications

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“…Since the 1990s, ionotropic gelation has been implemented in the development of polymeric biomaterials [ 50 ]. Chitosan structures encapsulating antibiotics [ 51 ], antioxidants [ 52 ] and growth mediators [ 53 ] have been acquired, exemplifying how adaptable this method is. This technique has so many advantages: it is simple, economical, and needs no complicated equipment or solvents, and takes a very short time to be completed [ 54 ].…”

Section: Methods Of Fabrication Of Chitosan Productsmentioning

confidence: 99%

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

et al. 2022

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Chitosan is a natural anionic polysaccharide with a changeable architecture and an abundance of functional groups; in addition, it can be converted into various shapes and sizes, making it appropriate for a variety of applications. This article examined and summarized current developments in chitosan-based materials, with a focus on the modification of chitosan, and presented an abundance of information about the fabrication and use of chitosan-derived products in periodontal regeneration. Numerous preparation and modification techniques for enhancing chitosan performance, as well as the uses of chitosan and its metabolites, were reviewed critically and discussed in depth in this study. Chitosan-based products may be formed into different shapes and sizes, considering fibers, nanostructures, gels, membranes, and hydrogels. Various drug-loaded chitosan devices were discussed regarding periodontal regeneration.

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Section: Methods Of Fabrication Of Chitosan Productsmentioning

confidence: 99%

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

et al. 2022

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“…Higher entrapment efficiency (99.6%) was found with the indirect method. Entrapment efficiency is bound to increase with increasing concentration of TPP, because it acts as a polyanionic cross linker agent [34]. Use of PPC results in enormous attachment of drug molecules with those of the polymer with the aid of TPP, resulting in the entrapment of drug molecules [35].…”

Section: Percentage Yield and Entrapment Efficiencymentioning

confidence: 99%

Design and Evaluation of pH Sensitive PEG-Protamine Nanocomplex of Doxorubicin for Treatment of Breast Cancer

et al. 2022

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Cancer is the most common cause of mortality worldwide. There is dire need of modern strategies—such as surface modification of nanocarriers—to combat this global illness. Incorporation of active targeting ligands has arisen as a novel platform for specific tumor targeting. The aim of the current study was to formulate PEG-protamine complex (PPC) of doxorubicin (DOX) for treatment of breast cancer (BC). DOX coupling with PEG can enhance cell-penetrating ability: combating resistance in MDA-MB 231 breast cancer cells. Ionic gelation method was adopted to fabricate a pH sensitive nanocomplex. The optimized nanoformulation was characterized for its particle diameter, zeta potential, surface morphology, entrapment efficiency, crystallinity, and molecular interaction. In vitro assay was executed to gauge the release potential of nanoformulation. The mean particle size, zeta potential, and polydispersity index (PDI) of the optimized nanoparticles were observed to be 212 nm, 15.2 mV, and 0.264, respectively. Crystallinity studies and Fourier transform infrared (FTIR) analysis revealed no molecular interaction and confirmed the amorphous nature of drug within nanoparticles. The in vitro release data indicate sustained drug release at pH 4.8, which is intracellular pH of breast cancer cells, as compared to the drug solution. PPC loaded with doxorubicin can be utilized as an alternative and effective approach for specific targeting of breast cancer.

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“…Chitosan is the only positively charged polysaccharide and has been employed in various applications such as preparation of colloidal nanoparticles that wields interaction with negatively charged polyelectrolytes electrostatically [ 71 ]. Chitosan-based nanoparticles can be produced using various methods such as cross-linking process, ionic gelation and solvent evaporation [ 71 , 72 , 73 ]. This biopolymer-based formulation has been gaining interest by researchers due to numerous advantages.…”

Section: Nanocarrier Systems For Oral Delivery Of Astaxanthinmentioning

confidence: 99%

“…On the other hand, the FRAP values for free astaxanthin were reduced over time, which could be due to low solubility of free astaxanthin in the alkaline condition and decreased antioxidant activity of astaxanthin. It was suggested that these drawbacks can be overcome by encapsulating astaxanthin within the chitosan-based nanoparticles to enhance the bioavailability as well as providing a sustained release of oral astaxanthin [ 72 ].…”

Section: Nanocarrier Systems For Oral Delivery Of Astaxanthinmentioning

confidence: 99%

“…On top of that, the nano-sized chitosan-based formulations have enhanced water solubility due to the higher surface area. This factor helps the particles to pass through the cell membranes, contributing to the improvement of oral bioavailability of astaxanthin [ 72 , 73 ]. Overall, encapsulating astaxanthin into chitosan-based nanoparticles weighted more advantages than the disadvantages.…”

Section: Nanocarrier Systems For Oral Delivery Of Astaxanthinmentioning

confidence: 99%

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Nanocarrier System: State-of-the-Art in Oral Delivery of Astaxanthin

et al. 2022

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Astaxanthin (3,3′-dihydroxy-4,4′-diketo-β-β carotene), which belongs to the xanthophyll class, has shown potential biological activity in in vitro and in vivo models including as a potent antioxidant, anti-lipid peroxidation and cardiovascular disease prevention agent. It is mainly extracted from an alga, Haematococcus pluvialis. As a highly lipid-soluble carotenoid, astaxanthin has been shown to have poor oral bioavailability, which limits its clinical applications. Recently, there have been several suggestions and the development of various types of nano-formulation, loaded with astaxanthin to enhance their bioavailability. The employment of nanoemulsions, liposomes, solid lipid nanoparticles, chitosan-based and PLGA-based nanoparticles as delivery vehicles of astaxanthin for nutritional supplementation purposes has proven a higher oral bioavailability of astaxanthin. In this review, we highlight the pharmacological properties, pharmacokinetics profiles and current developments of the nano-formulations of astaxanthin for its oral delivery that are believed to be beneficial for future applications. The limitations and future recommendations are also discussed in this review.

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Chitosan-Tripolyphosphate Nanoparticles Prepared by Ionic Gelation Improve the Antioxidant Activities of Astaxanthin in the In Vitro and In Vivo Model

Cited by 31 publications

References 49 publications

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

Drug-Loaded Chitosan Scaffolds for Periodontal Tissue Regeneration

Design and Evaluation of pH Sensitive PEG-Protamine Nanocomplex of Doxorubicin for Treatment of Breast Cancer

Nanocarrier System: State-of-the-Art in Oral Delivery of Astaxanthin

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