Chlamydia pneumoniae and asthma

Cook, Paul; Davies, Paul; Tunnicliffe, W S; Ayres, Jon G.; Honeybourne, D.; Wise, R.

doi:10.1136/thx.53.4.254

Cited by 110 publications

(72 citation statements)

References 43 publications

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“…As proposed by EKMAN et al [18] a MIF IgA titre $512 was also considered as evidence of acute infection. There are no firm criteria for serological evidence of previous or persistent infection, thus an IgG titre $64 and <512, or an IgA titre $16 and <512 were considered indicative of previous or persistent infection [19].…”

Section: Chlamydia Pneumoniae Serologymentioning

confidence: 99%

Chlamydia pneumoniae infection in adults with chronic cough compared with healthy blood donors

Birkebæk¹,

Jensen

Seefeldt

et al. 2000

Eur Respir J

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In a small uncontrolled study, persistent cough has recently been found to be associated with serological evidence of acute Chlamydia pneumoniae infection. In order to assess whether C. pneumoniae plays a role in chronic cough, the prevalence of C. pneumoniae infection in 201 adult patients with chronic cough was compared with the prevalence in 106 healthy blood donors without respiratory tract symptoms in the preceding 3 months. A microimmunofluorescence antibody test was used to determine C. pneumoniae antibodies in the immunoglobulin (Ig)M, IgG and IgA fractions. Further, nasopharyngeal aspirates from the 201 patients were examined for C. pneumoniae deoxyribonucleic acid by polymerase chain reaction (PCR).As judged by serology, nine patients (4%) and one control (1%) had acute C. pneumoniae infection, and 92 patients (46%) and 42 controls (40%) had previous or chronic C. pneumoniae infection. Of the nine patients with acute infection, three were C. pneumoniae PCR positive, and they all had an IgM antibody titre response. The remaining six patients had either an IgG antibody titre of $512 (five patients) or an IgA antibody titre of $512 (one patient). None of these six patients had detectable IgM antibodies.The mean cough period for the five IgG positive patients (10.8 weeks) was significantly longer than the mean cough period for the remaining patient population (6.4 weeks; p=0.004).It is concluded that Chlamydia pneumoniae infection was not statistically significantly more prevalent in patients with chronic cough than in healthy blood donors, and that Chlamydia pneumoniae appears to have a minor role in patients with chronic cough. Direct detection of Chlamydia pneumoniae by polymerase chain reaction on nasopharyngeal aspirates is highly correlated with detectable immunoglobulin M antibodies, but in the late stages of prolonged cough serological testing of immunoglobulin G and immunoglobulin A may be more beneficial for obtaining a microbiological diagnosis. Eur Respir J 2000; 16: 108±111.

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Section: Chlamydia Pneumoniae Serologymentioning

confidence: 99%

Chlamydia pneumoniae infection in adults with chronic cough compared with healthy blood donors

Birkebæk¹,

Jensen

Seefeldt

et al. 2000

Eur Respir J

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“…Recent studies have suggested that this organism may have a role in the pathogenesis of newly diagnosed and chronic stable asthma in both adults and children [9][10][11][12][13]. However, these studies have been based on serological tests, which cannot reliably differentiate between past and present infection or acute and chronic infection and which may be cross-reactive with other Chlamydia species.…”

mentioning

confidence: 99%

Increased frequency of detection ofChlamydophila pneumoniaein asthma

Biscione

Corne²,

Chauhan³

et al. 2004

Eur Respir J

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Previous studies have suggested that chronic Chlamydophila pneumoniae infection may play a role in the pathogenesis of asthma. However, most studies have been based on serology and have been unable to differentiate acute from chronic infection.The present authors assessed the presence of acute and chronic C. pneumoniae infection in 74 spouse pairs, each consisting of one atopic asthmatic and one nonatopic nonasthmatic. Nasal secretions were sampled every 2 weeks from October to December and actively replicating C. pneumoniae infection was detected by specific RT-PCR.C. pneumoniae was detected in 31 out of 709 samples analysed, 23 (6.4%) were positive in 362 samples from asthmatic participants and in eight out of 347 (2.3%) samples from their normal spouses (with a significant difference in infection rates, 95% confidence interval: 4.2%, 1.2-7.2%). A total of 16 (22%) asthmatic and seven (9%) normal participants were positive at least once during the study.These data confirm that Chlamydophila pneumoniae infection is detected more frequently among asthmatic participants than normal control participants. Further studies are required to confirm whether infections are also present in the lower airway and whether Chlamydophila pneumoniae infection plays a role in disease pathogenesis. Eur Respir J 2004; 24: 745-749.

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“…Infection with Chlamydophila pneumoniae, an obligately intracellular pathogen, has been suggested to be associated with severe non-atopic asthma (Cook et al, 1998), corticosteroid -dependent or -resistant asthma (Black et al, 2000;Hahn et al, 1998;von Hertzen et al, 2002), and asthma with persistent airflow limitation (Pasternack et al, 2005;ten Brinke, 2008). C. pneumoniae has an innate propensity to persist, and can cause chronic or latent infections in various structural and immune cells.…”

Section: Introductionmentioning

confidence: 99%

Chlamydophila pneumoniae inhibits corticosteroid-induced suppression of metalloproteinase-9 and tissue inhibitor metalloproteinase-1 secretion by human peripheral blood mononuclear cells

Park

Lee

Kwon

et al. 2012

Journal of Medical Microbiology

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Chlamydophila pneumoniae infection has been suggested to be associated with severe asthma characterized by persistent airway limitation, which may be related to airway remodelling. We investigated whether C. pneumoniae infection affected the secretion of metalloproteinase-9 (MMP9) and tissue inhibitor metalloproteinase-1 (TIMP1), and altered the responsiveness of inflammatory cells to corticosteroids. Human peripheral blood mononuclear cells (PBMCs) were cultured in vitro in the presence or absence of C. pneumoniae. Secretion of both MMP9 and TIMP1 was strongly suppressed by dexamethasone treatment in uninfected cells. MMP9 secretion was also significantly inhibited by dexamethasone in C. pneumoniae-infected cells, but TIMP1 secretion was not; hence the MMP9 to TIMP1 ratio decreased. Interestingly, expression of human glucocorticoid receptor b, which is believed to confer resistance to corticosteroids, was enhanced by dexamethasone treatment in C. pneumoniae-infected PBMCs. We conclude that C. pneumoniae infection may promote airway remodelling by decreasing the ratio of MMP9 to TIMP1 secreted by inflammatory cells, and by altering cellular responsiveness to corticosteroids.

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Chlamydia pneumoniae and asthma

Cited by 110 publications

References 43 publications

Chlamydia pneumoniae infection in adults with chronic cough compared with healthy blood donors

Chlamydia pneumoniae infection in adults with chronic cough compared with healthy blood donors

Increased frequency of detection ofChlamydophila pneumoniaein asthma

Chlamydophila pneumoniae inhibits corticosteroid-induced suppression of metalloproteinase-9 and tissue inhibitor metalloproteinase-1 secretion by human peripheral blood mononuclear cells

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