Chlamydia trachomatis and its interaction with the cellular retromer

Banhart, Sebastian; Rose, Laura J.; Aeberhard, Lukas; Koch-Edelmann, Sophia; Heuer, Dagmar

doi:10.1016/j.ijmm.2017.10.006

Cited by 3 publications

(3 citation statements)

References 98 publications

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“…Multiple STIs have the potential to influence HPV infection, although literature data report that C. trachomatis and T. vaginalis are among the main infections associated with HPV virus. Similarly, studies report that C. trachomatis contributes to the acquisition of high-risk HPV viruses; however, the present study did not observe an association between these two pathogens [ 7 , 20 – 22 ]. We suggested that there is a possible cooperation between multiple microorganisms, contributing to cellular microenvironment changes that facilitate HPV infection.…”

Section: Discussioncontrasting

confidence: 80%

Human papillomavirus and Its Association with Other Sexually Transmitted Coinfection among Sexually Active Women from the Northeast of Brazil

Cunha

Belfort

Mendes

et al. 2020

Interdisciplinary Perspectives on Infectious Diseases

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Objective. To verify the association between HPV infection and the presence of coinfections (Chlamydia trachomatis, Trichomonas vaginalis, and Neisseria gonorrhoeae) in women in the state of Maranhão. Methods. HPV-DNA detection was performed by the nested PCR, using the primers PGMY09/11 and GP + 5/GP + 6. For the identification of sexually transmitted agents, conventional PCR was performed using the following primers: KL1/KL2 (Chlamydia trachomatis), TVA5/TVA6 (Trichomonas vaginalis), and HO1/HO3 (Neisseria gonorrhoeae). DNA-HPV positive samples were subjected to automated sequencing for genotyping. Results. Among the 353 women evaluated, 204 (57.8%) had HPV-DNA, of which 140 (68.6%) exhibited HPV/STIs, while 64 (31.4%) had the only HPV. T. vaginalis infection showed a positive association with HPV ( p = 0.003 ). Women without cervical lesions were predominant (327/92.6%); however, the largest number of lesions was reported in women who had HPV/coinfections (18/8.8%). Multiple regression analysis showed that both HPV only and the concomitant presence of HPV/STI were able to indicate the occurrence of epithelial lesions (R = 0.164; R2 = 0.027). Conclusion. The findings suggest that the presence of T. vaginalis can contribute to HPV infection, and HPV/IST association may influence the development of cervical intraepithelial lesions that are precursors of cervical cancer.

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Section: Discussioncontrasting

confidence: 80%

Human papillomavirus and Its Association with Other Sexually Transmitted Coinfection among Sexually Active Women from the Northeast of Brazil

Cunha

Belfort

Mendes

et al. 2020

Interdisciplinary Perspectives on Infectious Diseases

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“…Chlamydia trachomatis is the most prevalent bacterial pathogen that leads to sexually transmitted diseases (STD) in the world [1,2]. The serotypes D-K are associated with urogenital tract infection, resulting in serious complications including ectopic pregnancy, abortion, infertility, and pelvic inflammatory disease in women [2,3]. The invasive serovars L1-L3 can cause lymphogranuloma venereum (LGV) that can lead to serious disseminated infections of the lymphatic system [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…The serotypes D-K are associated with urogenital tract infection, resulting in serious complications including ectopic pregnancy, abortion, infertility, and pelvic inflammatory disease in women [2,3]. The invasive serovars L1-L3 can cause lymphogranuloma venereum (LGV) that can lead to serious disseminated infections of the lymphatic system [2,3]. In the United States, among the 2.3 million STD cases reported to the Centers for Disease Control and Prevention (CDC) in 2017, C. trachomatis infection remained the most common condition reported.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis

Liu

et al. 2021

BioMed Research International

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The obligate intracellular bacterium Chlamydia trachomatis is a group of worldwide human pathogens that can lead to serious reproductive problems. The frequent clinical treatment failure promoted the development of novel antichlamydial agents. Here, we firstly reported a group of pyrroloisoxazolidine-inhibited C. trachomatis in a dose-dependent manner in vitro. Among them, compounds 1 and 2 exhibited the strongest inhibitory activity with IC50 values from 7.25 to 9.73 μM. The compounds disturbed the whole intracellular life cycle of C. trachomatis, mainly targeting the middle reticulate body proliferation stages. Besides, the compounds partially inhibited the chlamydial infection by reducing elementary body infectivity at high concentration. Our findings suggest the potential of pyrroloisoxazolidine derivatives as promising lead molecules for the development of antichlamydial agents.

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Presence ofChlamydia trachomatisDNA in the amniotic fluid in women with preterm prelabor rupture of membranes

Kacerovský

Romero²,

Plíšková

et al. 2019

The Journal of Maternal-Fetal & Neonatal Medicine

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Chlamydia trachomatis and its interaction with the cellular retromer

Cited by 3 publications

References 98 publications

Human papillomavirus and Its Association with Other Sexually Transmitted Coinfection among Sexually Active Women from the Northeast of Brazil

Human papillomavirus and Its Association with Other Sexually Transmitted Coinfection among Sexually Active Women from the Northeast of Brazil

Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis

Presence ofChlamydia trachomatisDNA in the amniotic fluid in women with preterm prelabor rupture of membranes

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