Chlamydia Trachomatis Promotes 3T3 Cell
Differentiation into Adipocytes

Petyaev, Ivan M.; Zigangirova, N. A.; Kapotina, Lydia N.; Fedina, Elena D.; Kyle, Nigel H.

doi:10.17219/acem/37215

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…The vital role of lipids as intracellular nutrients for the proliferation of Chlamydia has been documented [ 125 , 126 ]. A current in vitro study has shown the ability of Chlamydia to infect preadipocytes and promote their differentiation to adipocytes in the 3T3-L1 cell line, suggesting the possibility that Chlamydia can induce infectobesity [ 127 ]. The animal models support the idea that Chlamydia activates lipid pathways during infection.…”

Section: Adipocytes As Infection Targets and Their Relationship With ...mentioning

confidence: 99%

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

López‐Ortega

Moreno-Corona

Cruz-Holguin

et al. 2022

IJMS

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The current obesity pandemic has been expanding in both developing and developed countries. This suggests that the factors contributing to this condition need to be reconsidered since some new factors are arising as etiological causes of this disease. Moreover, recent clinical and experimental findings have shown an association between the progress of obesity and some infections, and the functions of adipose tissues, which involve cell metabolism and adipokine release, among others. Furthermore, it has recently been reported that adipocytes could either be reservoirs for these pathogens or play an active role in this process. In addition, there is abundant evidence indicating that during obesity, the immune system is exacerbated, suggesting an increased susceptibility of the patient to the development of several forms of illness or death. Thus, there could be a relationship between infection as a trigger for an increase in adipose cells and the impact on the metabolism that contributes to the development of obesity. In this review, we describe the findings concerning the role of adipose tissue as a mediator in the immune response as well as the possible role of adipocytes as infection targets, with both roles constituting a possible cause of obesity.

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Section: Adipocytes As Infection Targets and Their Relationship With ...mentioning

confidence: 99%

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

López‐Ortega

Moreno-Corona

Cruz-Holguin

et al. 2022

IJMS

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show abstract

“…138 The proposed mechanisms involve worsening insulin resistance in the setting of prediabetes or diabetes, and propagating differentiation of the preadipocyte cell line into mature fat cells. 139 The obesity-associated patterns in gut microbiota inherently impaired neurocognitive behavior in an experimental setting by disturbing intestinal barrier function, increasing circulating endotoxins, and increasing lymphocyte expression of some of the calcium-binding receptors. 140 These patterns increased neuroinflammation and disrupted cerebrovascular homeostasis.…”

Section: Environmental Mechanismsmentioning

confidence: 99%

Obesity and Chronic Pain

Narouze

Souzdalnitski

2015

Regional Anesthesia and Pain Medicine

114

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The combination of obesity and pain may worsen a patient's functional status and quality of life more than each condition in isolation. We systematically searched PubMed/MEDLINE and the Cochrane databases for all reports published on obesity and pain. The prevalence of combined obesity and pain was substantial. Good evidence shows that weight reduction can alleviate pain and diminish pain-related functional impairment. However, inadequate pain control can be a barrier to effective lifestyle modification and rehabilitation. This article examines specific pain management approaches for obese patients and reviews novel interventional techniques for treatment of obesity. The infrastructure for simultaneous treatment of obesity and pain already exists in pain medicine (eg, patient education, behavioral medicine approaches, physical rehabilitation, medications, and interventional treatment). Screening for obesity, pain-related disability, and behavioral disorders as well as monitoring of functional performance should become routine in pain medicine practices. Such an approach requires additional physician and staff training. Further research should focus on better understanding the interplay between these 2 very common conditions and the development of effective treatment strategies.

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“…Such intracellular bacteria may also be associated with development of neurodegenerative and behavioral disorders. For example, there is evidence that Chlamydophila pneumoniae may promote differentiation of preadipocyte cells into mature fat cells and be possibly associated with development of metabolic syndrome, fatty liver, or nonalcoholic steatohepatitis [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Lycopene Inhibits Propagation of Chlamydia Infection

et al. 2017

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Chlamydiaceae is a family of obligate intracellular pathogenic bacteria with similar developmental cycles and cell biology responsible for a wide range of diseases in different hosts including genital and eye inflammatory diseases, arthritis, and inflammatory diseases of the respiratory and cardiovascular systems. In the present paper, we report that lycopene, one of the main dietary carotenoids, which is present in tomato and some other fruits, has a strong inhibitory effect on C. trachomatis and C. pneumoniae infections in alveolar macrophages. This finding was documented by both immunofluorescence analysis and electron microscopy. It was noted that lycopene treatment inhibited intracellular phase of the chlamydial developmental cycle and resulted in a significant loss of infectious progeny. The antichlamydial effect of lycopene was also confirmed in a clinical setting. There was a significant reduction of IgG antibodies against C. pneumoniae in the serum of volunteers treated for a month with oral ingestion of 7 mg of lycopene. Additional studies are needed to further explore the antichlamydial activity of lycopene and its possible effect on C. pneumoniae in relation to antichlamydial activity of lycopene to mechanisms of atherosclerosis.

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Chlamydia Trachomatis Promotes 3T3 Cell Differentiation into Adipocytes

Cited by 4 publications

References 20 publications

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

Obesity and Chronic Pain

Lycopene Inhibits Propagation of Chlamydia Infection

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