Chloral hydrate in pediatric magnetic resonance imaging: evaluation of a 10-year sedation experience administered by radiologists

Toro, Rodrigo; Rascovsky, Simón; Arango, Adriana; Angel, Gabriel Jaime; Calvo, Vı́ctor; Delgado, Jorge

doi:10.1007/s00247-014-3091-0

Cited by 45 publications

(31 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The CH group received a single oral dose of 50 mgÁkg À1 chloral hydrate, with saline placebo for intranasal administration. This is in keeping with our current practice and within the published dose range for pediatric sedation for nonpainful procedures (17).…”

Section: Methodssupporting

confidence: 84%

A prospective, randomized, double‐blind trial of intranasal dexmedetomidine and oral chloral hydrate for sedated auditory brainstem response (ABR) testing

Reynolds

Rogers

Medellin

et al. 2016

Pediatric Anesthesia

View full text Add to dashboard Cite

show abstract

Section: Methodssupporting

confidence: 84%

A prospective, randomized, double‐blind trial of intranasal dexmedetomidine and oral chloral hydrate for sedated auditory brainstem response (ABR) testing

Reynolds

Rogers

Medellin

et al. 2016

Pediatric Anesthesia

View full text Add to dashboard Cite

show abstract

“…The recommended dose of chloral hydrate is 50-100 mg/kg (up to a maximum of 2 g) [13]. The success rate of chloral hydrate sedation for pediatric MRI varies from 78%-100% [14][15][16][17][18][19] and is affected by the total dose administered, age, fasting status, and neurodevelopmental disability [14,15,18,19]. When 100 mg/kg of chloral hydrate is administered, the sedation success rate was 96% in children under 48 months but decreased to 86% in those older than 48 months [20].…”

Section: Ministrationmentioning

confidence: 99%

Drug selection for sedation and general anesthesia in children undergoing ambulatory magnetic resonance imaging

Jung

2020

Yeungnam Univ J Med

View full text Add to dashboard Cite

The prevalence of magnetic resonance imaging (MRI) for diagnosing and monitoring a wide range of disease in children continues to expand with the efficacy benefit of providing high-resolution images of tissue anatomy and quantitative function and the safety advantage of a lack of ionizing radiation [1,2]. Aspects of MRI scans such as loud noises, confined bore of the magnet, and the required immobility to prevent motion artifacts are the causes of anxiety and barriers to successful performance of the procedure in children younger than 6 years and those at any age with development delay, claustrophobia, or involuntary movements or con-The demand for drug-induced sedation for magnetic resonance imaging (MRI) scans have substantially increased in response to increases in MRI utilization and growing interest in anxiety in children. Understanding the pharmacologic options for deep sedation and general anesthesia in an MRI environment is essential to achieve immobility for the successful completion of the procedure and ensure rapid and safe discharge of children undergoing ambulatory MRI. For painless diagnostic MRI, a single sedative/anesthetic agent without analgesia is safer than a combination of multiple sedatives. The traditional drugs, such as chloral hydrate, pentobarbital, midazolam, and ketamine, are still used due to the ease of administration despite low sedation success rate, prolonged recovery, and significant adverse events. Currently, dexmedetomidine, with respiratory drive preservation, and propofol, with high effectiveness and rapid recovery, are preferred for children undergoing ambulatory MRI. General anesthesia using propofol or sevoflurane can also provide predictable rapid time to readiness and scan times in infants or children with comorbidities. The selection of appropriate drugs as well as sufficient monitoring equipment are vital for effective and safe sedation and anesthesia for ambulatory pediatric MRI.

show abstract

“…Chloral hydrate has a long history of use in pediatrics as an effective sedative/hypnotic for facilitating a wide range of diagnostic procedures not associated with pain. 1 In the large database of the Pediatric Sedation Research Consortium, chloral hydrate was the drug used in ∼25% of 11 822 cases in which sedation was provided by pediatricians. 2 Although chloral hydrate has long been regarded as "safe," it does have the potential for profound respiratory depression and resedation.…”

mentioning

confidence: 99%

Retrospective Comparison of Intranasal Dexmedetomidine and Oral Chloral Hydrate for Sedated Auditory Brainstem Response Exams

Reynolds

Rogers

Capehart

et al. 2016

Hospital Pediatrics

View full text Add to dashboard Cite

show abstract

Chloral hydrate in pediatric magnetic resonance imaging: evaluation of a 10-year sedation experience administered by radiologists

Cited by 45 publications

References 18 publications

A prospective, randomized, double‐blind trial of intranasal dexmedetomidine and oral chloral hydrate for sedated auditory brainstem response (ABR) testing

A prospective, randomized, double‐blind trial of intranasal dexmedetomidine and oral chloral hydrate for sedated auditory brainstem response (ABR) testing

Drug selection for sedation and general anesthesia in children undergoing ambulatory magnetic resonance imaging

Retrospective Comparison of Intranasal Dexmedetomidine and Oral Chloral Hydrate for Sedated Auditory Brainstem Response Exams

Contact Info

Product

Resources

About