Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated hydrophobic/hydrophilic resins

Bonding efficiency and durability: current possibilities

“…CHX can be used as an antiproteolytic "primer" solution directly applied on the dentin surface, or after phosphoric acid etching and rinsing 74,78,79,80,81,82 or incorporated into the acid etching agent 83,84 or within the adhesive system composition. 74,85,86,87 The use of 2% CHX solution as an effective and nonspecific protease inhibitor primer, after acid-etching, is attractive from a clinical point of view, since it is already used in other oral health situations as an antimicrobial agent. 88 Compared to control, aged CHX-treated dentin relates to higher bond strength values 73,74,77,78,79,80,89,90,91,92 which are interestingly equivalent to each other in most of the immediate evaluations.…”

“…103 A reservoir of CHX for controlled release would be derived from its inclusion into primers and/or adhesives: 87 addition of relatively low CHX concentrations to commercial adhesive, chiefly in ethanol-solvated hydrophobic resins, was shown feasible in this sense. 85,86,87 Controversial results look as if they were related to the concentration of CHX added to the adhesive formulation and/or to the chemical compositions of the adhesives, 93,102,107,108 which may influence resin water sorption, and hence its solubility, degree of conversion, and mechanical properties. 85,109 To endorse CHX incorporation into adhesives, Stanislawczuk et al 87 advised the conduction of further studies in more clinically relevant conditions.…”

“…85,86,87 Controversial results look as if they were related to the concentration of CHX added to the adhesive formulation and/or to the chemical compositions of the adhesives, 93,102,107,108 which may influence resin water sorption, and hence its solubility, degree of conversion, and mechanical properties. 85,109 To endorse CHX incorporation into adhesives, Stanislawczuk et al 87 advised the conduction of further studies in more clinically relevant conditions. In vitro studies have already attested that CHXcontaining primers of two-step self-etch and simplified etch-and-rinse adhesives are capable of, respectively, inhibiting MMPs 108 and reducing nanoleakage, 104 precluding time-related bond strength loss.…”

“…115 Adversely, a limitation of CHX indication as an enzymatic inhibitor is that its effect seems not to be indefinitely long. 85 Because CHX molecule is large and water soluble, it may be gradually leached out from the adhesive interface, 92 especially when in contact with an external environment (through marginal gaps, for instance). 105 Remaining concentration then becomes no longer appropriate to exert noticeable antiproteolytic effects.…”

Effect of Different Concentration of Disinfectant Incorporated on Hardness of Heat Cured Acrylic Denture Base

“…This reduction could be attributed to the release of chlorhexidine components from acrylic resin. They found that Chlorhexidine and other antimicrobial agents have been shown to be released at relatively high rates from various methacrylate polymers (14) .…”