2015
DOI: 10.1902/jop.2015.150075
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Chlorhexidine Uptake and Release From Modified Titanium Surfaces and Its Antimicrobial Activity

Abstract: This study suggests that CHX release is significantly influenced by titanium surface modifications and that SLA and RBM might provide effective CHX uptake capacity in the saliva-filled oral cavity.

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Cited by 18 publications
(20 citation statements)
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“…Consistent with the XPS findings of residual CHX‐related elements on the titanium surface, Kozlovsky et al have shown that a considerable percentage of the available CHX that contacts a titanium surface gets adsorbed and is gradually released over ≥24 hours 42 . The persistence of CHX on the titanium surface in association with its known cytotoxicity may explain the present results that show that growth of cells was hindered on the CHX‐treated samples 39 , 41 , 42 …”
Section: Discussionsupporting
confidence: 90%
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“…Consistent with the XPS findings of residual CHX‐related elements on the titanium surface, Kozlovsky et al have shown that a considerable percentage of the available CHX that contacts a titanium surface gets adsorbed and is gradually released over ≥24 hours 42 . The persistence of CHX on the titanium surface in association with its known cytotoxicity may explain the present results that show that growth of cells was hindered on the CHX‐treated samples 39 , 41 , 42 …”
Section: Discussionsupporting
confidence: 90%
“…Previous studies found that the purportedly favorable CHX adsorption on dental tissues and gradual release, i.e. “substantivity,” also applies around implants 41 , 42 . Consistent with the XPS findings of residual CHX‐related elements on the titanium surface, Kozlovsky et al have shown that a considerable percentage of the available CHX that contacts a titanium surface gets adsorbed and is gradually released over ≥24 hours 42 .…”
Section: Discussionmentioning
confidence: 56%
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“…First, CHX is capable of attaching to the surfaces (implant) and gradual release over time. 38 It possesses bactericidal activity even 24 hours after washing. 18,38 Thus, the residual CHX can be transferred to the culture medium and maintain its bactericidal effect, affecting the results.…”
Section: Discussionmentioning
confidence: 99%
“…For example, although the cytotoxic effect of chlorhexidine on osteoblastic cells has been extensively documented in the context of dental procedures and peri-implantitis in particular, 29,30 even to this date preclinical studies are recommending the use of chlorhexidine against peri-implant biofilms solely based on antimicrobial assays. 31,32 In the present study, osteoblastic cell response to the surfaces following the adjunctive use of the aforementioned biomaterials is extensively characterized providing a relevant model for reosseointegration. Nevertheless, the present study shares the limitation of in vitro investigations for drawing clinical conclusions.…”
Section: Discussionmentioning
confidence: 99%