Chlorin e6 and polydopamine modified gold nanoflowers for combined photothermal and photodynamic therapy

Wu, Fengren; Liu, Yongjia; Song, Dianwen; Qian, Jiwen; Zhu, Bangshang

doi:10.1039/c9tb02646k

Cited by 44 publications

(24 citation statements)

References 53 publications

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“…88 The same strategy can be used with other linkers or gold nanoparticle shapes, as it occurs with glutathionefunctionalised Au nanostars further linked with chlorin e6, by using a similar chemistry. 89 Other PSs such as indocyanine green (ICG) can be electrostatically bonded to gold-bearing nanostructures, for example Au nanorods/MoS 2 nanoagents, 90 or porous Au@Rh nanostructures. The latter constitutes one example of the fourth generation of PSs 91 (Figure 3b).…”

Section: A Inorganic-based Nanostructuresmentioning

confidence: 99%

Photodynamic therapy: photosensitizers and nanostructures

Escudero

Carrillo‐Carrión

Castillejos

et al. 2021

Mater. Chem. Front.

139

102

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Section: A Inorganic-based Nanostructuresmentioning

confidence: 99%

Photodynamic therapy: photosensitizers and nanostructures

Escudero

Carrillo‐Carrión

Castillejos

et al. 2021

Mater. Chem. Front.

139

102

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“…Both in vitro and in vivo evaluation confirmed the superior phototoxicity and synergistic effects of this multifunctional nanosystem on killing cancer cells. [ 101 ] However, many of the reported PTT‐PDT dual therapies simply leverage the combination of gold nanomaterials and PS molecules, still requiring individual light sources for each modality, which cause unnecessary complexity in clinical applications. Ideally, the photosensitive agent for simultaneous PTT and PDT should be photoexcited under the same light irradiation.…”

Section: Multifunctional Gold Nanomaterials For Combinatorial Phototherapymentioning

confidence: 99%

The Golden Age: Shining the Light on Theragnostics

Yang

Wang

2021

Advanced NanoBiomed Research

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Gold nanoparticles have attracted unprecedented attention as one of the leading nanomaterials in the field of biomedicine. Of particular interest are their inherent and geometrically tunable optical properties upon the interaction with light, facilitating breakthroughs in light‐mediated diagnosis and therapeutics. Herein, an up‐to‐date overview of the current research in utilizing versatile gold‐based nanosystems with distinctive optical features for optical imaging and phototherapy is provided. The recent advances in optical biosensing, surface‐enhanced Raman scattering‐based detection, photoacoustic imaging, optical coherence tomography, photothermal therapy, light‐triggered drug release, photodynamic therapy, and optomodulation of neural functions using the novel and elegant gold nanostructures of unique design are summarized. In recognition of the burgeoning popularity of integrating multiple diagnostic and therapeutic functions in one system, recent developments of various multifunctional gold nanoplatforms for the light‐enabled concomitant diagnosis and therapy are also highlighted. In the end, the current limitations and perspectives in clinical translation of gold nanomaterial‐assisted photodiagnosis and phototherapy are discussed along with the concluding remarks.

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“…More interestingly, the coating of some nanomaterials with PDA could introduce some advanced characteristics for the nanosystem, such as low cytotoxicity, high biocompatibility, strong near-infrared absorption, good thermal stability, and high photothermal conversion efficiency ( Singh et al, 2020 ; Wu et al, 2021 ). Taking the advantages of high photothermal conversion efficiency, PDA nanomaterials have been widely applied for anticancer treatment, which can directly inhibit cancer cell growth by promoting autophagy, apoptosis, and so on ( Hao et al, 2019 ; Wu et al, 2020 ; Dai et al, 2021a ). Moreover, combining targeted drug delivery and PTT, the PDA nanosystem is expected to synergistically eliminate tumor growth ( Wu et al, 2020 ; Dai et al, 2021a ; Dai et al, 2021b ).…”

Section: Introductionmentioning

confidence: 99%

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

et al. 2022

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Bacterial infection remains one of the most dangerous threats to human health due to the increasing cases of bacterial resistance, which is caused by the extensive use of current antibiotics. Photothermal therapy (PTT) is similar to photodynamic therapy (PDT), but PTT can generate heat energy under the excitation of light of specific wavelength, resulting in overheating and damage to target cells or sites. Polydopamine (PDA) has been proved to show plenty of advantages, such as simple preparation, good photothermal conversion effects, high biocompatibility, and easy functionalization and adhesion. Taking these advantages, dopamine is widely used to synthesize the PDA nanosystem with excellent photothermal effects, good biocompatibility, and high drug loading ability, which therefore play more and more important roles for anticancer and antibacterial treatment. PDA nanosystem-mediated PTT has been reported to induce significant tumor inhibition, as well as bacterial killings due to PTT-induced hyperthermia. Moreover, combined with other cancer or bacterial inhibition strategies, PDA nanosystem-mediated PTT can achieve more effective tumor and bacterial inhibitions. In this review, we summarized the progress of preparation methods for the PDA nanosystem, followed by advances of their biological functions and mechanisms for PTT uses, especially in the field of antibacterial treatments. We also provided advances on how to combine PDA nanosystem-mediated PTT with other antibacterial methods for synergistic bacterial killings. Moreover, we further provide some prospects of PDA nanosystem-mediated PTT against intracellular bacteria, which might be helpful to facilitate their future research progress for antibacterial therapy.

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Chlorin e6 and polydopamine modified gold nanoflowers for combined photothermal and photodynamic therapy

Abstract: A nanoscale system (PDA-Ce6-GSH-AuNFs) for synergistic photothermal and photodynamic therapy was successfully prepared, which exhibited high tumour inhibition efficacy.

Cited by 44 publications

References 53 publications

Photodynamic therapy: photosensitizers and nanostructures

Photodynamic therapy: photosensitizers and nanostructures

The Golden Age: Shining the Light on Theragnostics

Advances and Potentials of Polydopamine Nanosystem in Photothermal-Based Antibacterial Infection Therapies

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