Chlormequat chloride promotes rat embryonic growth and GH-IGF-1 axis

Xiagedeer, Bayindala; Kang, Chenping; Hou, Xiaohong; Hu, Hong; Xiao, Qianqian; Hao, Weidong

doi:10.1016/j.tox.2019.152326

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…These include plasticisers, pharmaceutics, personal and healthcare products, industrial chemicals (solvent and lubricants), flame retardants and agrochemicals ( Papalou et al , 2019 ). Agrochemicals are an important class of EDCs, with various studies noting the ED effects associated with certain insecticides ( De Angelis et al , 2009 ), herbicides ( Harada et al , 2016 ), fungicides ( Kackar et al , 1997 ), algaecides ( Hiromori et al , 2016 ), nematicides, acaricides ( Yang et al , 2019 ), fumigants ( Goldman et al , 2007 ), fertilisers ( Poulsen et al , 2018 ), and plant growth regulators ( Xiagedeer et al , 2020 ). Therefore, when these agrochemicals reach non-target aquatic environments they can elicit ED effects on wildlife species through different modes of action.…”

Section: Endocrine Disrupting Effects Observed In South African Watermentioning

confidence: 99%

Agrochemicals in freshwater systems and their potential as endocrine disrupting chemicals: A South African context

Horak

Horn

Pieters

2021

Environmental Pollution

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South Africa is the largest agrochemical user in sub-Saharan Africa, with over 3 000 registered pesticide products. Although they reduce crop losses, these chemicals reach non-target aquatic environments via leaching, spray drift or run-off. In this review, attention is paid to legacy and current-use pesticides reported in literature for the freshwater environment of South Africa and to the extent these are linked to endocrine disruption. Although banned, residues of many legacy organochlorine pesticides (endosulfan and dichlorodiphenyltrichloroethane (DDT)) are still detected in South African watercourses and wildlife. Several current-use pesticides (triazine herbicides, glyphosate-based herbicides, 2,4-dichlorophenoxyacetic acid (2,4-D) and chlorpyrifos) have also been reported. Agrochemicals can interfere with normal hormone function of non-target organism leading to various endocrine disrupting (ED) effects: intersex, reduced spermatogenesis, asymmetric urogenital papillae, testicular lesions and infertile eggs. Although studies investigating the occurrence of agrochemicals and/or ED effects in freshwater aquatic environments in South Africa have increased, few studies determined both the levels of agricultural pesticides present and associated ED effects. The majority of studies conducted are either laboratory-based employing in vitro or in vivo bioassays to determine ED effects of agrochemicals or studies that investigate environmental concentrations of pesticides. However, a combined approach of bioassays and chemical screening will provide a more comprehensive overview of agrochemical pollution of water systems in South Africa and the risks associated with long-term chronic exposure.

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Section: Endocrine Disrupting Effects Observed In South African Watermentioning

confidence: 99%

Agrochemicals in freshwater systems and their potential as endocrine disrupting chemicals: A South African context

Horak

Horn

Pieters

2021

Environmental Pollution

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“…The programming effect of maternal leptin on the develop ment of offspring can be mediated via epigenetic modifica tions, including methylation of regulatory regions of genes and changes in the expression of signaling factors that affect the growth and maturation of organs and tissues in fetuses (Rey nolds et al, 2017). Insulin-like growth factors 1 and 2 (IGF1, IGF2) play a significant role in the somatic development of the fetus (Petry et al, 2010;Xiagedeer et al, 2020;Hattori et al, 2021). These factors are synthesized and secreted into the blood of the fetus by both placenta and fetal liver (Nawathe et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Influence of leptin administration to pregnant mice on fetal gene expression and adaptation to sweet and fatty food in adult offspring of different sexes

Denisova,

Makarova

2024

Vestn. VOGiS

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Elevated leptin in pregnant mice improves metabolism in offspring fed high-calorie diet and its influence may be sex-specific. Molecular mechanisms mediating leptin programming action are unknown. We aimed to investigate programming actions of maternal leptin on the signaling function of the placenta and fetal liver and on adaptation to high-calorie diet in male and female offspring. Female C57BL/6J mice received leptin injections in mid-pregnancy. Gene expression was assessed in placentas and in the fetal brain and liver at the end of pregnancy. Metabolic parameters and gene expression in the liver, brown fat and hypothalamus were assessed in adult male and female offspring that had consumed sweet and fatty diet (SFD: chow, lard, sweet biscuits) for 2 weeks. Females had lower blood levels of leptin, glucose, triglycerides and cholesterol than males. Consuming SFD, females had increased Ucp1 expression in brown fat, while males had accumulated fat, decreased blood triglycerides and liver Fasn expression. Leptin administration to mothers increased Igf1 and Dnmt3b expression in fetal liver, decreased post-weaning growth rate, and increased hypothalamic Crh expression in response to SFD in both sexes. Only in male offspring this administration decreased expression of Fasn and Gck in the mature liver, increased fat mass, blood levels of glucose, triglycerides and cholesterol and Dmnt3a expression in the fetal liver. The results suggest that the influence of maternal leptin on the expression of genes encoding growth factors and DNA methyltransferases in the fetal liver may mediate its programming effect on offspring metabolic phenotypes.

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Study of a new matrix certified reference material for simultaneous measurement of two plant growth regulators residues in tomato

Chen,

Shi,

Yang

et al. 2024

Microchemical Journal

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Chlormequat chloride promotes rat embryonic growth and GH-IGF-1 axis

Cited by 5 publications

References 42 publications

Agrochemicals in freshwater systems and their potential as endocrine disrupting chemicals: A South African context

Agrochemicals in freshwater systems and their potential as endocrine disrupting chemicals: A South African context

Influence of leptin administration to pregnant mice on fetal gene expression and adaptation to sweet and fatty food in adult offspring of different sexes

Study of a new matrix certified reference material for simultaneous measurement of two plant growth regulators residues in tomato

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