Chloromycetin in the Treatment of Patients with Typhus Fever

Chloramphenicol and Other Antibiotics in the Treatment of Typhoid Fever and Typhoid Carriers

“…In this group of treated patients, as in others previously studied (1,(7)(8)(9), there were no evidences of toxic manifestations attributable to the chloramphenicol. Abnormalities in the white and red blood cells and in the urine were recorded in a number of instances but were considered to be part of the disease picture of typhoid or of the complications which developed.…”

Fermentation

“…Other patents pertinent to the penicillin process cover the use of oxazoline as a defoamer (100); the use of chlorine dioxide treatment of the culture medium to aid in combating contamination (888); the preparation of corn-steep by a special process making it more favorable for penicillin production and other microbiological uses (184); and the use of sulfite compounds in penicillin production media (186).…”

“…Assay and purification procedures and chemical properties have been published (10,104,188). This antibiotic shows considerable promise as it is reported active against diseases caused by Rickettsia and viruses (185,186,188). Chloromycetin is the first antibiotic to be chemically synthesized in practical yields (46) and the synthetic process may have commercial use.…”

Excerpts from: Preliminary Report on the Beneficial Effect of Chloromycetin in the Treatment of Typhoid Fever☆

“…Reports on the use of Chloromycetin in the treatment of human infections, up to the time of writing, have been confined to its use in epidemic typhus 4,5 and in scrub typhus. 6 In both of these rickettsial infections Chloromycetin has demonstrated marked therapeutic effectiveness.…”