Cholecalciferol for prophylaxis against antituberculosis therapy-induced liver disorders among naïve patients with pulmonary tuberculosis: A randomized, comparative study

Hasanain, Ahmad Farooq Alsayed; Zayed, Ali Abdel-Azeem Hasan; Mahdy, Reem Ezzat; Nafee, Amany Mohamed Adawi

doi:10.4103/ijmy.ijmy_19_17

Cited by 13 publications

(3 citation statements)

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“…Current study design was based on earlier studies represented that free 25(OH)D showed higher correlation with the actual vitamin D deficient states than 25(OH)D (23). Similar to some earlier studies, female patients were predominant sex group and most of patients belonged to the age group 40–50 (n=48, 60%) (1, 20). Joint manifestations proportion were higher than previous reports (14%–36%) (24).…”

Section: Discussionsupporting

confidence: 89%

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Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Kiani¹,

Abedini²,

Adcock³

et al. 2018

Journal of Medical Biochemistry

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SummaryBackgroundDespite negative association between 25-hydroxy vitamin D and incidence of many chronic respiratory diseases, this feature was not well studied in sarcoidosis. Current study investigated the association between 25-hydroxy vitamin D deficiency with sarcoidosis chronicity, disease activity, extra-pulmonary skin manifestations, urine calcium level and pulmonary function status in Iranian sarcoidosis patients. Results of this study along with future studies, will supply more effective programs for sarcoidosis treatment.MethodsEighty sarcoidosis patients in two groups of insufficient serum level and sufficient serum level of 25-hydroxy vitamin D were studied. Course of sarcoidosis was defined as acute and chronic sarcoidosis. Pulmonary function test (PFT) was assessed by spirometry. Skin involvements were defined as biopsy proven skin sarcoidosis. 24-hour urine calcium level was used to specify the disease activity. Stages of lung involvements were obtained by CT-scan and chest X-ray. The statistical analyses were evaluated using Statistical Package for the Social Sciences.ResultsA significant negative correlation was obtained between vitamin D deficiency in sarcoidosis patients and disease chronic course and stages two to four of lung involvements. Considering other parameters of the disease and vitamin D deficiency, no significant correlation was detected.ConclusionsIn conclusion, results of the current study implies in the role of vitamin 25(OH)D deficiencies in predicting the course of chronic sarcoidosis. Furthermore, it was concluded that vitamin 25(OH)D deficiency can direct pulmonary sarcoidosis toward stage 2–4 of lung involvements.

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Section: Discussionsupporting

confidence: 89%

“…Thereby, the study was approved by the Ethics Committee of Shahid Beheshti medical sciences university (SBMU 1.REC.1393.71). An expert methodologist estimated the study population size due to statistics guidelines (19, 20).…”

Section: Methodsmentioning

confidence: 99%

Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Kiani¹,

Abedini²,

Adcock³

et al. 2018

Journal of Medical Biochemistry

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“…From 2011 to 2020, publications per year were nearly stationary but no reported publications in 2021. Near half of publications were case reports (185)(186)(187)(188)(189), but the others were variety of randomized controlled trials (190,191), prospective (192,193), retrospective (194,195), cohort (196)(197)(198) and observational studies studying the presentation, causes, diagnosis and outcomes of DILI but no studies in liver transplantation in DILI and toxic liver patients.…”

Section: Toxic and Drug Induced Liver Injurymentioning

confidence: 99%

Liver diseases among Arab world, current state and unmet needs, a scoping review

Almansoury,

Abdel-Gawad,

Abdelghani

et al. 2023

Global Gastroenterology

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Vitamin D supplementation for chronic liver diseases in adults

Bjelaković

Nikolova

Bjelaković

et al. 2021

Cochrane Database of Systematic Reviews

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Cholecalciferol for prophylaxis against antituberculosis therapy-induced liver disorders among naïve patients with pulmonary tuberculosis: A randomized, comparative study

Abstract: Adjuvant cholecalciferol supplementation may be protective against ATT-LD without extra adverse effects. Before recommending the routine use of cholecalciferol supplementation for prevention of ATT-LD, larger scale studies are recommended.

Cited by 13 publications

References 0 publications

Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Association Between Vitamin D Deficiencies in Sarcoidosis with Disease Activity, Course of Disease and Stages of Lung Involvements

Liver diseases among Arab world, current state and unmet needs, a scoping review

Vitamin D supplementation for chronic liver diseases in adults

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