Cholecystokinin as a stimulus in drug discrimination learning

Melton, Pamela M.; Kopman, Jeffrey A.; Riley, Anthony L.

doi:10.1016/0091-3057(93)90458-6

Cited by 14 publications

(3 citation statements)

References 12 publications

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“…On test, performance on both levers was rewarded, and so if, as proposed, CCK reduces the incentive value of the pellet outcome, the rats should have chosen the 3-hr deprivation lever under control of the low-incentive value of the outcome. The same argument may be applied to Melton et al's (1993) study, because on days when the saccharin solution was poisoned, it was preceded by an injection of CCK that should have produced the assignment of a low-incentive value, thus providing a discriminative cue for the aversion.…”

Section: Discussionmentioning

confidence: 99%

“…Corwin et al found that performance on the 3-hr lever was significantly increased by the injection of CCK, a result they interpreted as suggesting that the rats could detect the internal state induced by CCK and that this generalized significantly to the state induced by 3-hr deprivation. Further, Melton, Kopman, and Riley (1993), using a conditioned taste aversion procedure with a 5.6 fig/kg dose of CCK as the discriminandum, reported being able to train rats to discriminate days on which they were poisoned following consumption of a saccharine solution from days on which they were not poisoned.…”

Section: Motivational Control Of Instrumental Actionmentioning

confidence: 99%

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Role of cholecystokinin in the motivational control of instrumental action in rats.

Balleine¹,

Dickinson²

1994

Behavioral Neuroscience

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In 4 experiments, the role of cholecystokinin (CCK) in the motivational control of instrumental performance in rats was assessed. Following instrumental training with food rewards, injections of CCK (either 2 micrograms/kg or 4 micrograms/kg) had no effect on instrumental performance in extinction, even when the opportunity was given to learn about the incentive value of the food outcome under CCK. These results contrasted markedly with the effects of shifts in food deprivation. Rewarded instrumental performance was, however, reduced by both doses of CCK, suggesting that CCK may mediate deprivation-related shifts in incentive value. Tests of this hypothesis found that the alimentary CCK antagonist devazepide (MK329) attenuated the devaluation of a food outcome produced by exposure to the outcome in a nondeprived state. These data are interpreted as suggesting that CCK may act as a satiety-specific incentive signal.

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Section: Discussionmentioning

confidence: 99%

Section: Motivational Control Of Instrumental Actionmentioning

confidence: 99%

Role of cholecystokinin in the motivational control of instrumental action in rats.

Balleine¹,

Dickinson²

1994

Behavioral Neuroscience

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“…Taste aversion presumably results from an association of ingesting novel food or flavored fluid resulting in nausea/malaise. DTA has proven sensitive to, for example, the discriminative effects of the opiate antagonist naloxone (Kautz et al 1989) and the neuro(octa)peptide cholecystokinin (Melton et al 1993) at low doses. Hence, the current study explored the possibility of establishing the CB 1 receptor antagonist SR-141716 as a discriminative stimulus, using DTA as the baseline [employing lithium chloride (LiCl) as the "toxin"].…”

Section: Introductionmentioning

confidence: 99%

Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist

Järbe¹,

Harris

et al. 2004

Psychopharmacology

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Conditioned Taste Avoidance Drug Discrimination Procedure: Assessments and Applications

Riley

Clasen

Friar

2016

Current Topics in Behavioral Neurosciences

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In the present chapter, we summarize much of the work on the taste avoidance drug discrimination procedure, presenting the logic for its initial introduction and the extension of the procedure in the investigation of the discriminative properties of various drugs. Results from these assessments parallel those from more traditional operant and maze designs in classifying and characterizing the discriminative properties of drug. At the same time, this design reveals a procedure that is sensitive in such assessments by indexing these stimulus properties more rapidly and at lower doses than in the more traditional procedures (in some cases for drugs heretofore resistant in their detection). Importantly, much remains to be learned about the taste avoidance procedure in that the nature of such learning remains unknown and the specific parameters under which it can be established and generalized and its neurochemical and neuroanatomical bases are largely unexplored. The application of drug discrimination learning to human drug abuse continues to be an important consideration for this specific design (as well as that of drug discrimination procedures in general), and recent parallels between drug use and food intake in terms of its regulation by interoceptive stimuli suggests a possible role of the loss of stimulus control in drug escalation and addiction (with possible therapeutic implications via the modulation of these interoceptive cues).

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Cholecystokinin as a stimulus in drug discrimination learning

Cited by 14 publications

References 12 publications

Role of cholecystokinin in the motivational control of instrumental action in rats.

Role of cholecystokinin in the motivational control of instrumental action in rats.

Discriminative stimulus effects in rats of SR-141716 (rimonabant), a cannabinoid CB1 receptor antagonist

Conditioned Taste Avoidance Drug Discrimination Procedure: Assessments and Applications

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