Choleragen‐induced cyclic nucleotide response in a lower eukaryote

Daniel, John W.; Oleinick, Nancy L.; Whistler, Susan

doi:10.1016/0014-5793(80)80421-2

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…A. Hildebrandt at the above address and Jeter 1985). However, the involvement of cAMP in the light-induced differentiation (sporulation) of Physarum polyeephalum has not been investigated in detail, though a hormone-like receptor system is indicated that controls the adenylate cyclase system (Daniel et al 1980) and a rapidly transient elevation of plasmodial cAMP levels after light exposure (Daniel 1981). The latter, however, was not detected by Akitaya et al (1985).…”

Section: Introductionmentioning

confidence: 99%

Sporulation delay by stable cAMP analogues in the slime moldPhysarum polycephalum

Brandt

Jastorff

Hildebrandt

1986

Roux’s Arch Dev Biol

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Plasmodial cells of the slime moldPhysarum polycephalum become competent for sporulation following a prolonged period of starvation in darkness. Then sporulation can be induced by illumination. Microinjections of the stable (Sp)- and (Rp)-diastereoisomers of adenosine cyclic 3',5' monothionophosphate before and during a sensitive period from the start of illumination until 5 h after lead to a significant delay in the sporulation process.Both of the diastereoisomers of cyclic AMP prolong the time for sporangia to form in darkness. However, the (Sp)-diastereoisomer is more effective and causes morphological changes in plasmodia.The experimental data suggest that cyclic AMP is decisively involved in light-induced differentiation in the lower eukaryotoPhysarum polycephalum.

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Section: Introductionmentioning

confidence: 99%