Cholestatic Hepatitis Following the Administration of Sodium Oxacillin

Higher Occurrence of Hepatotoxicity and Rash in Patients Treated with Oxacillin, Compared with Those Treated with Nafcillin and Other Commonly Used Antimicrobials

“…These ADRs included neutropenia (in 31 patients), rash (27), hepatotoxicity (12), and other (diarrhea, 2; serum sickness, 1; pruritus, 1; dyspnea, 1; and Neutropenia was the most frequently occurring ADR, occurring in association with 30 antibiotic courses (9.5%). Rash was the next most frequently occurring ADR, in 27 courses of antibiotics (8.5%).…”

“…Oxacillin-related hepatotoxicity has been reported in the adult medical literature to a limited extent [10][11][12][13][14][15][16]. However, reports in the pediatric literature are lacking, and the pediatric infectious diseases textbooks do not emphasize hepatotoxicity as a potential complication of oxacillin therapy [17,18].…”

Infectious diseases. Annual review of significant publicationsIt is regretted that reprints of this article are not available. Copies of the Journal can be obtained price 10s. 6d. post free from the publishers or usual agents.

“…Between 1952 and 1963, 2,000 cases of pneumococcal pneumonia and 529 instances of bacteremia were observed in a hospital, indicating the continued prevalence of that infection. Pneumococcus Types 1,7,8,4,3,12,14,19,6 and 2 in that order were the chief causes. Type 1 infection was associated with bacteremia in 66 per cent of cases.…”

“…He had severe hepatitis, pneumonia, splenomegaly and lymphadenitis. In retrospect, a transitory attack of pleurisy and pulmonic invasion, suspected as tuberculous 19 Trichinosis among 11 diners was treated with thialbendazole. The drug induced defervescence of the disease and a sense of well-being in four victims.…”

Hyperbilirubinemia during Quinupristin‐Dalfopristin Therapy in Liver Transplant Recipients: Correlation with Available Liver Biopsy Results

“…Such reports have documented a diverse clinical presentation that includes frank hepatitis with or without necrosis, granulomatous disease, cholestasis, steatosis, cholelithiasis, and pseudolithiasis. 26,27 Cholestatic disease was associated with amoxicillin-clavulanate, 28,29 ticarcillin-clavulanate, 30 mezlocillin, 31 the antistaphylococcal penicillins (flucloxacillin, cloxacillin, dicloxacillin, oxacillin, and nafcillin), [32][33][34][35] tetracycline, 36 imipenemcilastatin, 37 and others. Within the macrolidelincosamide-streptogramin family, there are also important and similar case descriptions.…”