Cholesterol and early development

Ellinger, Isabella; Chatuphonprasert, Waranya

doi:10.1016/b978-0-323-85857-1.00032-8

Cited by 1 publication

(1 citation statement)

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“…Cholesterol is the structural component of cell membranes and is a precursor for vitamin D and several steroid hormones (Woollett, 2011; Ellinger and Chatuphonprasert, 2022). Bile acids (BAs) are the major hepatic cholesterol metabolites that are synthesized via oxysterols through multiple enzymatic reactions.…”

Section: Introductionmentioning

confidence: 99%

Maternal sterol 27-hydroxylase is crucial for securing fetal development

Suzuki,

Nakano,

Miharada

et al. 2023

Preprint

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SummaryThe maternal body helps in providing nutrients and degrading toxic metabolites instead of the fetal body; disruptions in these mechanisms affect normal fetal development. Sterol 27-hydroxylase (Cyp27a1) is involved in the alternative pathway of bile acid synthesis, which is enhanced during pregnancy. However, its role in fetal development remains unclear. Here, we demonstrate that maternal Cyp27a1 activity is essential for progression of normal pregnancy and fetal organ formation. Depletion of maternalCyp27a1reduced the pregnancy rate and litter size. Newborn mice died of respiratory distress syndrome resulting from the absence of mature alveolar epithelial cells. These phenotypes were caused by 7α-hydroxycholesterol (7α-HC) accumulating inCyp27a1-deficient mice. Mechanistically, 7α-HC destabilized the Fau protein, mediating ribosome assembly, the downregulation of which caused poor polysome formation, lower protein synthesis, and impaired lung maturation. Overall, this study revealed an essential mechanism of securing fetal development by degrading a toxic metabolite in the maternal body.

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Section: Introductionmentioning

confidence: 99%