Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo)

Padaro, E; Delagnon, Kueviakoe Irenee Messanh; Feteke, L; Magnang, Hézouwè; Mawussi, Koffi; Layibo, Yao; Isac, Dovi Eteh; Yvon, Segbena Akuete

doi:10.11648/j.sjcm.20160502.13

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…While in SS males, there was no significant difference in the triglyceride level when compared to AS individuals and AA controls. Previous reports by Ephraim et al and Essohona et al reported no significant difference in TG between SCD patients and controls [ 32 , 44 ].…”

Section: Discussionmentioning

confidence: 82%

Plasma Lipids and Lipoproteins in Sickle Cell Disease Patients in the Northern West Bank, Palestine

Samarah

Srour

Dumaidi

2021

BioMed Research International

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Background. Lipid metabolism may be altered in red cell genetic disorders. The erythrocyte and plasma lipids are defected which may increase the risk of cardiovascular disease. In the present study, we hypothesized a possible link between severity of anemia and altered lipid profile in SCD. Methods. A total of 151 SCD patients, including 62 patients with sickle cell anemia (SS), 54 patients with sickle β-thalassemia (ST), and 35 individuals with sickle cell trait (AS), were studied. The control group consisted of 160 healthy individuals. Total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were enzymatically measured. Results. Total cholesterol and LDL-C were significantly lower ( P value < 0.001) in SS and ST patients compared to AS individuals and AA controls. However, LDL-C was significantly lower in AS individuals (both males and female) compared to AA controls ( P value < 0.001). The HDL-C in SS and ST patients (both males and females) was significantly lower than that in AS individuals ( P value < 0.001). In addition, the HDL-C was significantly higher in SS and ST males and AS (males and females) compared to AA controls ( P value < 0.001). The HDL-C was also significantly higher in SS males ( P value < 0.001) and females ( P value < 0.05) compared to ST patients. The HDL-C was significantly higher in AS individuals ( P value < 0.001) compared to AA controls. The triglycerides in SS males was significantly lower than that in ST patients ( P value < 0.001), but there was no significant difference when compared to AS individuals and AA controls. In contrast, triglycerides in SS females were significantly lower than those in ST ( P value < 0.05), AS ( P value < 0.001), and AA controls ( P value < 0.001). In males of ST patients, triglycerides were significantly higher than those observed in AS males and AA males ( P value < 0.001). In contrast, females of ST patients have a significantly lower triglycerides compared to AS and AA females ( P value < 0.001). Conclusions. In SCD, the plasma is affected in some way, especially the plasma cholesterol that was investigated in this study. Further prospective studies should examine the contribution of an altered lipid profile to the severity and clinical complications in SCD patients.

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Section: Discussionmentioning

confidence: 82%

Plasma Lipids and Lipoproteins in Sickle Cell Disease Patients in the Northern West Bank, Palestine

Samarah

Srour

Dumaidi

2021

BioMed Research International

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Risk factors of metabolic syndrome among adult Sudanese sickle cell anemia patients

Babiker

Kaddam

2018

BMC Hematol

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BackgroundSickle cell disease is a hereditary disorder characterized by haematological anaemia. Several studies assumed that adult sickle patients might develop metabolic syndrome features as hyperglycaemia, hypertension and dyslipidaemia. The aim of this study was to evaluate the metabolic syndrome risk factors among adult Sudanese with sickle cell anemia in the steady state.MethodsA prospective cross sectional study design was conducted among thirty adult patients with sickle cell anemia Hb SS (mean age 23 ± 6.1 years) and thirty healthy individuals matched for age and gender. Waist and hip circumferences were measured by simple tape. Venous blood sample were analysed to detect blood glucose level, uric acid, total cholesterol, triglycerides, low and high-density lipoprotein after 8 h overnight fasting by spectrophotometer. Blood pressure was measured by sphygmomanometer. National Cholesterol Education Program-Adult Treatment Panel III was utilised to define metabolic syndrome. Statistical analysis was performed SPSS software version 23. Continuous data were expressed using mean ± SD. P-value of < 0.05 (two-tailed) was used to establish statistical significance. Unpaired independent T- test was used.ResultsNo significant difference in mean systolic blood pressure in patients group compared to control (P value = 0.3). Mean value of diastolic blood pressure was significantly low in patients group compared to control (65.4 ± 10. 4 VS72.33 ± 8.27 mmHg, P value< 0.001). Fasting triglycerides level was comparable between patients group and control (P value = 0.56). While high-density lipoprotein was significantly lower in sicklers compared to control (30.2 ± 8.2 mg/dL vs 44.71 ± 1.85 mg/dL, P value< 0.001). Fasting blood glucose was significantly low in sickle compared to control (92.6 ± 13 mg/dL vs 106.83 ± 25.11 mg/dL P value< 0.001). Uric acid level was not statistically differed in patients group compared to control (p value = 0.5).ConclusionThere was significant decrease in fasting High-density lipoprotein, diastolic blood pressure, mean arterial pressure and fasting blood glucose among SCA patients compared to control. There was no significant difference in waist circumference, systolic blood pressure, fasting triglycerides and uric acid levels between patients and control groups.

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Cholesterol and Triglyceride Levels in Patients with Homozygous Sickle Cell Disease at Campus Teaching Hospital of Lomé (Togo)

Cited by 2 publications

References 10 publications

Plasma Lipids and Lipoproteins in Sickle Cell Disease Patients in the Northern West Bank, Palestine

Plasma Lipids and Lipoproteins in Sickle Cell Disease Patients in the Northern West Bank, Palestine

Risk factors of metabolic syndrome among adult Sudanese sickle cell anemia patients

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