2023
DOI: 10.1242/jcs.261563
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Cholesterol is required for activity-dependent synaptic growth

Amber Shaheen,
Claire L. Richter Gorey,
Adam Sghaier
et al.

Abstract: Changes in cholesterol content of neuronal membranes occur during development and brain aging. Little is known about whether synaptic activity regulates cholesterol levels in neuronal membranes and whether these changes affect neuronal development and function. We generated transgenic flies that express the cholesterol binding D4H domain of Perfringolysin O toxin and found increased levels of cholesterol in presynaptic terminals of Drosophila larval neuromuscular junctions following increased synaptic activity… Show more

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