2019
DOI: 10.1016/j.bbadis.2019.04.012
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Cholesterol metabolism, pancreatic β-cell function and diabetes

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Cited by 97 publications
(88 citation statements)
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References 96 publications
(98 reference statements)
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“…This is consistent with its reported role in postnatal mouse beta cell maturation and islet development 69 , where a switch from mTORC1 to AMPK signaling mediates a shift to oxidative metabolism and functional maturation 70,71 . During SC-islet maturation we also found downregulation of genes related to cholesterol homeostasis and the biosynthesis of fatty acids, processes that play a key role in beta cell function 31,38,72 .…”
Section: Discussionmentioning
confidence: 78%
“…This is consistent with its reported role in postnatal mouse beta cell maturation and islet development 69 , where a switch from mTORC1 to AMPK signaling mediates a shift to oxidative metabolism and functional maturation 70,71 . During SC-islet maturation we also found downregulation of genes related to cholesterol homeostasis and the biosynthesis of fatty acids, processes that play a key role in beta cell function 31,38,72 .…”
Section: Discussionmentioning
confidence: 78%
“…ABCA1 may also be crucial to maintaining b cell cholesterol homeostasis and function (14,15). Because cholesterol is an important factor for membrane organization and survival of b cells, cholesterol accumulation in b cells impairs glucose metabolism and reduces insulin secretion, resulting in the development of T2DM (16). A study showed that b cellspecific Abca1 knockout mice had significantly higher fasting blood glucose levels than their littermate controls because of a defect in the first-phase glucose-stimulated insulin release (17).…”
Section: Introductionmentioning
confidence: 99%
“…In addition to SBP, a high level of TC is another major predictor of cardiovascular risk (Zhang et al, 2019 ). Patients with T2DM show a cluster of lipid abnormalities which is related to cholesterol and fatty acid accumulation in pancreatic β-cells (Perego et al, 2019 ). Altered regulation of the synthesis, absorption and excretion of cholesterol may contribute to atherosclerosis (Wang et al, 2017 ).…”
Section: Discussionmentioning
confidence: 99%