Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage

Liu, Zhou; Liu, Lingying; Zhang, Zhijian; Chen, Zuhui; Zhao, Bin

doi:10.1002/14651858.cd008184.pub2

Cited by 8 publications

(6 citation statements)

References 40 publications

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“…We screened 493 reviews after removal of duplicates. Based on their titles and abstracts, a total of 82 reviews met the inclusion criteria and made up the data set 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 . The 82 relevant CSRs included 1177 RCTs.…”

Section: Resultsmentioning

confidence: 99%

An assessment of randomized controlled trials (RCTs) for non-communicable diseases (NCDs): more and higher quality research is required in less developed countries

Hong

2015

Sci Rep

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Research is crucial to implement evidence-based health interventions for control of non-communicable diseases (NCDs). This study aims to assess main features of randomized controlled trials (RCTs) for control of NCDs, and to identify gaps in clinical research on NCDs between high-income and less developed countries. The study included 1177 RCTs in 82 Cochrane Systematic reviews (CSRs) and evaluated interventions for adults with hypertension, diabetes, stroke, or heart diseases. Multivariate logistic regression analyses were conducted to explore factors associated with risk of bias in included RCTs. We found that 78.2% of RCTs of interventions for major NCDs recruited patients in high-income countries. The number of RCTs included in the CSRs was increasing over time, and the increasing speed was more noticeable for RCTs conducted in middle-income countries. RCTs conducted in less developed countries tended to be more recently published, less likely to be published in English, with smaller sample sizes, and at a higher risk of bias. In conclusion, there is still a lack of research evidence for control of NCDs in less developed countries. To brace for rising NCDs and avoid waste of scarce research resources, not only more but also higher quality clinical trials are required in low-and-middle-income countries.

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Section: Resultsmentioning

confidence: 99%

An assessment of randomized controlled trials (RCTs) for non-communicable diseases (NCDs): more and higher quality research is required in less developed countries

Hong

2015

Sci Rep

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“…Pre-treatment with statins is associated with lower stroke severity, at high as well as at low to moderate doses [70]. Other data suggest that we cannot draw any conclusion about the effectiveness and safety of lowering cholesterol in aneurismal SAH because insufficient reliable evidence from trials [71]. There are several possible explanations for these disparities.…”

Section: Strokementioning

confidence: 99%

Statins in neurological disorders: An overview and update

Malfitano

Marasco

Proto

et al. 2014

Pharmacological Research

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“…Though the impact of serum lipids on DCI may appear intuitive, and studies of cholesterol reducing agents (statins) in SAH are increasing,[ 13 14 30 ] there are hardly few studies directly relating serum lipid levels to DCI. [ 17 30 ] These studies surprisingly noted higher baseline LDL-C levels to have protective effect on DCI, contrary to the anticipated function of statins,[ 17 30 ] whereas an animal study noted cholesterol-fed rabbits to have greater degree of vasospasm following experimental SAH.…”

Section: Discussionmentioning

confidence: 99%

Serum lipid profile spectrum and delayed cerebral ischemia following subarachnoid hemorrhage: Is there a relation?

et al. 2015

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Background:Serum lipid abnormalities are known to be important risk factors for vascular disorders. However, their role in delayed cerebral ischemia (DCI), the major cause of morbidity after subarachnoid hemorrhage (SAH) remains unclear. This study was an attempt to evaluate the spectrum of lipid profile changes in SAH compared to matched controls, and their relation with the occurrence of DCI.Methods:Admission serum lipid profile levels were measured in patients of SAH and prospectively studied in relation to various factors and clinical development of DCI.Results:Serum triglyceride (TG) levels were significantly lower among SAH patients compared to matched controls (mean [±standard deviation (SD)] mg/dL: 117.3 [±50.4] vs. 172.8 [±89.1], P = 0.002), probably because of energy consumption due to hypermetabolic response. Patients who developed DCI had significantly higher TG levels compared to those who did not develop DCI (mean [±SD] mg/dL: 142.1 [±56] vs. 111.9 [±54], P = 0.05). DCI was noted in 62% of patients with TG >150 mg/dL, compared to 22% among the rest (P = 0.01). Total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and lipoprotein (a) neither showed a significant difference between SAH and controls and nor any significant association with DCI. Multivariate analysis using binary logistic regression adjusting for the effects of age, sex, systemic disease, World Federation of Neurosurgical Societies grade, Fisher grade, and clipping/coiling, revealed higher TG levels to have significant independent association with DCI (P = 0.01).Conclusions:Higher serum TG levels appear to be significantly associated with DCI while other lipid parameters did not show any significant association. This may be due to their association with remnant cholesterol or free fatty acid-induced lipid peroxidation.

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Cholesterol-reducing agents for aneurysmal subarachnoid haemorrhage

Cited by 8 publications

References 40 publications

An assessment of randomized controlled trials (RCTs) for non-communicable diseases (NCDs): more and higher quality research is required in less developed countries

An assessment of randomized controlled trials (RCTs) for non-communicable diseases (NCDs): more and higher quality research is required in less developed countries

Statins in neurological disorders: An overview and update

Serum lipid profile spectrum and delayed cerebral ischemia following subarachnoid hemorrhage: Is there a relation?

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