Cholesterol-rich LDL perfused at physiological LDL-cholesterol concentration induces platelet aggregation and PAF-acetylhydrolase activation

（崔德华）, DH Chui; Marotta, Francesco; Rao, ML; Liu, DS; Sc, Zhang; Ideo, Courtney

doi:10.1016/0753-3322(91)90152-j

Cited by 19 publications

(8 citation statements)

References 18 publications

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“…Cholesterol has effects on the vasculature, and high blood cholesterol concentrations modify the action of platelets and enhance platelet aggregation by their action on the platelet activating factor. 29 Moreover, high cholesterol concentrations have a neuroprotective effect by modulating the action of some enzymes (glutamyltransferase) that play a role in amino acid uptake and transport. 30 The proven action of cholesterol as a buffer neutralizing free radicals 31 is also a finding to be taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

Serum lipid levels and in-hospital mortality in patients with intracerebral hemorrhage

Roquer

Rodríguez-Campello²,

Gomis³

et al. 2005

Neurology

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Section: Discussionmentioning

confidence: 99%

Serum lipid levels and in-hospital mortality in patients with intracerebral hemorrhage

Roquer

Rodríguez-Campello²,

Gomis³

et al. 2005

Neurology

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“…Some studies have suggested a neuroprotective role of cholesterol that could be attributed to its antioxidant properties [28]. Other studies have suggested that low HDL cholesterol in the blood enhances the action of platelet aggregation by acting on the platelet activating factor [29,30]. In addition, high concentrations of cholesterol might have a neuroprotective effect by modulating the action of the gamma glutamyltransferase and acetylcholinesterase enzymes [31].…”

Section: Discussionmentioning

confidence: 99%

Association of total serum cholesterol with functional outcome following home care rehabilitation in Italian patients with stroke

Cataldo

Calcara

Caputo

et al. 2012

Disability and Health Journal

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“…High blood cholesterol concentrations modify the action of platelets such that exposure to low density lipoprotein cholesterol enhances platelet aggregation by its action on platelet activating factor 16. Rabbits fed a high cholesterol diet have larger experimentally induced infarcts associated with an increase in platelet deposition in the thrombus at the infarct 17.…”

Section: Discussionmentioning

confidence: 99%

Influence of cholesterol on survival after stroke: retrospective study

Dyker

Weir

Lees

1997

BMJ

102

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Objective: To study the comparative importance of environment and genes in the development of islet cell autoimmunity associated with insulin dependent diabetes mellitus. Design: Population based study of diabetic twins. Setting: Danish population. Subjects: 18 monozygotic and 36 dizygotic twin pairs with one or both partners having insulin dependent diabetes. Main outcome measures: Presence of islet cell antibodies, insulin autoantibodies, and autoantibodies to glutamic acid decarboxylase (GAD65) in serum samples from twin pairs 10 years (range 0-30 years) and 9.5 years (2-30 years) after onset of disease. Results: In those with diabetes the prevalence of islet cell antibodies, insulin autoantibodies, and autoantibodies to glutamic acid decarboxylase in the 26 monozygotic twins was 38%, 85%, and 92%, respectively, and in the dizygotic twins was 57%, 70%, and 57%, respectively. In those without diabetes the proportions were 20%, 50%, and 40% in the 10 monozygotic twins and 26%, 49%, and 40% in the 35 dizygotic twins. Conclusion: There is no difference between the prevalence of islet cell autoantibodies in dizygotic and monozygotic twins without diabetes, suggesting that islet cell autoimmunity is environmentally rather than genetically determined. Furthermore, the prevalence of islet cell antibodies was higher in the non-diabetic twins than in other first degree relatives of patients with insulin dependent diabetes. This implies that the prenatal or early postnatal period during which twins are exposed to the same environment, in contrast with that experienced by first degree relatives, is of aetiological importance.

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Cholesterol-rich LDL perfused at physiological LDL-cholesterol concentration induces platelet aggregation and PAF-acetylhydrolase activation

Cited by 19 publications

References 18 publications

Serum lipid levels and in-hospital mortality in patients with intracerebral hemorrhage

Serum lipid levels and in-hospital mortality in patients with intracerebral hemorrhage

Association of total serum cholesterol with functional outcome following home care rehabilitation in Italian patients with stroke

Influence of cholesterol on survival after stroke: retrospective study

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