Cholesteryl ester transfer protein Taq IB polymorphism and its association with serum lipid levels and longevity in Chinese Bama Zhuang population

Abstract

BackgroundTaqIB polymorphism in the cholesteryl ester transfer protein (CETP) gene has been reported to be associated with serum high-density lipoprotein cholesterol (HDL-C) levels and longevity in several populations, but controversial results also arose probably due to racial/ethnic diversity. Bama is a remote and mountainous county located in the northwest of Guangxi, People's Republic of China, which has been well known for its longevity for centuries. The current study was to investigate the possible association of CETP TaqIB polymorphism with serum lipid levels and longevity in the Bama Zhuang population.MethodsThe CETP TaqIB genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism in 523 long-lived inhabitants (long-lived group, LG; aged 90-107 years) and 498 healthy controls without longevity family history (non-long-lived group, non-LG; aged 40-69 years) residing in Bama County.ResultsThe levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were higher but TG, HDL-C/LDL-C ratio and the prevalence of dyslipidemia were lower in LG than in non-LG (P < 0.001 for all). There were no differences in the allelic and genotypic frequencies between the two groups (P > 0.05). Serum HDL-C levels and HDL-C/LDL-C ratio in LG were different among the genotypes (P < 0.01 for each), the subjects with B2B2 and B1B2 genotyes had higher HDL-C levels and HDL-C/LDL-C ratio than the subjects with B1B1genotye, whereas the levels of TC and HDL-C in non-LG were different among/between the genotypes (P < 0.01 for each), the B2 allele carriers had lower TC and higher HDL-C levels than the B2 allele noncarriers. Serum TG and HDL-C levels and HDL-C/LDL-C ratio were correlated with genotypes in LG, whereas serum TC and HDL-C levels were associated with genotypes in non-LG (P < 0.05-0.001).ConclusionsThe association of CETP TaqIB polymorphism and serum lipid profiles is different between LG and non-LG in the Chinese Bama Zhuang population. CETP TaqIB polymorphism might be one of the longevity-related genetic factors in this population.

Multi-Locus Candidate Gene Analyses of Lipid Levels in a Pediatric Turkish Cohort: Lessons Learned onLPL, CETP, LIPC, ABCA1,andSHBG

“…The associations obtained in this study have the same directional effect as previous studies; theB2B2 genotype of CETP was associated with favorable effects on LDL-C and HDL-C levels among children and adolescents. The allelic direction of the association was the same in different populations (Chinese or Spanish) and age groups (adults versus children) (Ló pezSimó n et al, Pan et al, 2012). In a cohort of Greek children, Taq1B B2 allele carriers also had higher HDL-C levels ( p < 0.001) (Smart et al, 2010).…”

“…The B2 allele has previously been associated with higher HDL-C levels in Chinese adults (Pan et al, 2012). In a study on children, CETP variation has contributed to the variation in HDL-C levels in Spanish prepubescent girls (Ló pez-Simó n et al, 2009).…”

“…Using a candidate gene approach, we examined six SNPs, previously found to associate with HDL-C or TG levels (Dunning et al, 2004;Eriksson et al, 2006;Haiman et al, 2005;Hodoglugil et al, 1999;Pan et al, 2012;Rip et al, 2006;Weissglas-Volkov et al, 2010) in adult populations, for association with dyslipidemia in children. An association is observed at CETP (rs708272) with HDL-C and BMI (in girls) levels.…”

“…Recently, several genetic loci that influence lipid levels in adulthood have been reported (Oliveira et al, 2010); alleles in ATP binding cassette transporter (ABCA1), hepatic lipase C514T (LIPC), lipoprotein lipase S447X (LPL), and cholesterol ester transfer protein (CETP) Taq1B affect HDL-C and triglyceride levels in adults (Hodoglugil et al, 1999;Pan et al, 2012;Rip et al, 2006;Weissglas-Volkov et al, 2010) Similarly, sex hormone levels and sex hormone binding globulin (SHBG) have important effects on lipid levels (particularly HDL-C) in children and adolescents (Agirbasli et al, 2010;Garcés et al, 2010). Additionally, genetic variations in SHBG (rs1799941 and rs6257) associate with circulating sex hormone levels in adults (Dunning et al, 2004;Eriksson et al, 2006;Haiman et al, 2005).…”

El metabolismo del colesterol: cada vez más complejo

“…También las catequinas del té son eficientes en disminuir en forma significativa los niveles de colesterol (Kim et al, 2011). Sin embargo, a pesar de los muchos estudios que muestran cambios en el sentido de regular los niveles de colesterol por el efecto de sustancias bioactivas de la dieta, es preciso notar que la respuesta de los individuos a los nutrientes no es común a todas las poblaciones, debido a diferencias polimórficas de varios genes que participan en el metabolismo lipídico, como el del colesterol (Aung et al, 2011;Kotani et al, 2011;Pan et al, 2012), o a modificaciones postranscripcionales de los productos génicos (Medina et al, 2011).…”