2016
DOI: 10.1016/bs.apha.2016.03.001
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Choline on the Move

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Cited by 11 publications
(3 citation statements)
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“…The neuronal high-affinity choline transporter (CHT; SLC5A7 ) is the rate-limiting step for the synthesis of ACh (Ennis & Blakely, 2016; Ferguson et al, 2004; Guyenet, Lefresne, Rossier, Beaujuan, & Glowinski, 1973; Haga, 2014; Parikh, St. Peters, Blakely, & Sarter, 2013; Sarter & Parikh, 2005; Simon, Atweh, & Kuhar, 1976). As such, the CHT is a major determinant of the capacity of cholinergic neurons to sustain elevated levels of cholinergic neuromodulation (Paolone, Angelakos, et al, 2013; Paolone, Mallory, et al, 2013).…”
Section: Unresponsive Chts In Stsmentioning
confidence: 99%
“…The neuronal high-affinity choline transporter (CHT; SLC5A7 ) is the rate-limiting step for the synthesis of ACh (Ennis & Blakely, 2016; Ferguson et al, 2004; Guyenet, Lefresne, Rossier, Beaujuan, & Glowinski, 1973; Haga, 2014; Parikh, St. Peters, Blakely, & Sarter, 2013; Sarter & Parikh, 2005; Simon, Atweh, & Kuhar, 1976). As such, the CHT is a major determinant of the capacity of cholinergic neurons to sustain elevated levels of cholinergic neuromodulation (Paolone, Angelakos, et al, 2013; Paolone, Mallory, et al, 2013).…”
Section: Unresponsive Chts In Stsmentioning
confidence: 99%
“…In parallel, there is a transporter-mediated uptake of free choline, including high-affinity transporter, for acetylcholine formation in neurons (149)(150)(151).…”
Section: The Quantitative Role Of Lyso-pc In Choline and Fatty Acid Transportmentioning
confidence: 99%
“…The capacity of the CHT to transport choline into the synapse is regulated tightly by mechanisms that determine the density and functionality of the CHT in the synaptosomal plasma membrane (Ferguson and Blakely, 2004; Ribeiro et al, 2006; Sarter and Parikh, 2005; Ennis and Blakely, 2016). Evidence supports the hypothesis that genetically-imposed, or spontaneously arising, variations in the capacity of the CHT impact levels of cholinergic neuromodulation and thereby modulate a range of fundamental cognitive, behavioral and physiological functions (Barwick et al, 2012; Ferguson et al, 2003, 2004; Holmstrand et al, 2014).…”
Section: Introductionmentioning
confidence: 99%