1988
DOI: 10.1037/0735-7044.102.5.662
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Cholinergic blockade in the rat impairs strategy selection but not learning and retention of nonspatial visual discrimination problems in a swimming pool.

Abstract: A procedure was developed to study black versus white and horizontal versus vertical pattern visual discriminations in a swimming pool. The effects of central cholinergic muscarinic receptor blockade by atropine sulfate was then evaluated. The drug treatment impaired acquisition but not retention. Behavioral observations showed that the control rats used a number of strategies during the process of problem solving that facilitated acquisition of the discrimination. Through modifications of training procedures,… Show more

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Cited by 64 publications
(29 citation statements)
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“…The involvement of the hippocampal cholinergic system in spatial memory and learning, as well as the capacity of cholinergic antagonists (such as scopolamine or atropine) to impair memory and learning have been extensively (investigated Whishaw and Petrie 1988, Mc Namara and Skelton 1993, Maaswinkel et al 1999, Fadda et al 2000. Drug effects have been reported to occur only when the drug is administered before the beginning of the task (Whishaw and Petrie 1988), with no effect on learning consolidation.…”
Section: Discussionmentioning
confidence: 98%
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“…The involvement of the hippocampal cholinergic system in spatial memory and learning, as well as the capacity of cholinergic antagonists (such as scopolamine or atropine) to impair memory and learning have been extensively (investigated Whishaw and Petrie 1988, Mc Namara and Skelton 1993, Maaswinkel et al 1999, Fadda et al 2000. Drug effects have been reported to occur only when the drug is administered before the beginning of the task (Whishaw and Petrie 1988), with no effect on learning consolidation.…”
Section: Discussionmentioning
confidence: 98%
“…Studies using cholinergic drugs in learning and memory tasks show consistent results when the drug is administered before the test. It has been reported that muscarinic antagonists (scopolamine or atropine) impair spatial navigation tasks in the Morris water maze (Whishaw 1985, Whishaw and Petrie 1988, Cozzolino et al 1994, Dringenberg and Zalan 1999.…”
Section: Introductionmentioning
confidence: 99%
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“…The finding that rats use various strategies in attempting to learn a new task have been reported previously (Krechevsky 1938;Whishaw and Petrie 1988). One idea is that during the learning or presolution phase, a rat may try multiple strategies, from which the correct one is eventually chosen (Krechevsky 1938).…”
Section: Learning and Memory 73mentioning
confidence: 90%
“…A deficit in motor planning could potentially account for the increased latencies in male lesioned mice on the spatial and cued swim maze tasks (Arters et al, 1998). In addition, the central cholinergic system is likely involved with movement strategies in rodents (Wishaw and Petrie, 1988). This might begin to explain the difference in neonatal nBM lesion effects on male and female mice.…”
Section: Figurementioning
confidence: 97%