Cholinergic mediation of spatial memory in the preweanling rat: Application of the radial arm maze paradigm.

Rauch, Scott L.; Raskin, Lisa A.

doi:10.1037/0735-7044.98.1.35

Cited by 52 publications

(40 citation statements)

References 23 publications

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“…Although several studies have shown that early spatial experience plays a signi®cant role in later performance on spatial navigation tasks (e.g., Cramer et al, 1988;Rauch & Raskin, 1984), this presents an interesting paradox concerning the development of memory, infantile amnesia. Memories for events learned in infancy are likely to be forgotten more rapidly than those formed in adulthood (cf.…”

Section: Discussionmentioning

confidence: 99%

“…Spear & Riccio, 1994). With the establishment of spatial navigation in the preweanling animal, using the Morris water maze and the results of the radial arm maze studies (Cramer et al, 1988;Rauch & Raskin, 1984), a logical question to address is how well the rat pup retains its memory for spatial information. Of the limited ontogenetic Morris water maze studies conducted, Brown and Kraemer's (1997) work is the only one that systematically examined spatial retention in immature rats.…”

Section: Discussionmentioning

confidence: 99%

“…Speci®cally, rats that were trained and tested in a radial arm maze beginning at 16 and continuing through 20 days of age performed not only better than chance but signi®cantly better than agematched, naõ Ève controls when tested at 22, 23, 24, and 25 days of age (Rauch & Raskin, 1984). In addition, Cramer, P®ster, and Haig (1988) assessed the effects of early suckling experience on later spatial learning using a radial arm maze with shortened arms which accommodated the motoric demands placed upon the young rats.…”

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confidence: 99%

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Long‐term retention of spatial navigation by preweanling rats

Carman

Booze

Mactutus

2001

Developmental Psychobiology

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The present study was designed to examine retention of spatial information in the immature, Fischer-344N rat using a savings paradigm. Following training to locate a hidden platform using extramaze cues, preweanling animals (17 days of age) were immediately probed by testing in the tank with the platform removed. One week later, pups (26 days of age) were given an additional four training trials immediately followed by a second probe test to examine the animals' memory for the location of the platform. Animals that received initial training at 17 days of age demonstrated significant savings of information when tested after the retention interval. These data replicate our recent report of spatial navigation capabilities in the preweanling rat, and extend those findings by demonstrating that preweanling spatial navigation performance permits more rapid and accurate navigation following a 7-day retention interval after a "reinstatement" insufficient to produce accurate navigation in maturation controls.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Long‐term retention of spatial navigation by preweanling rats

Carman

Booze

Mactutus

2001

Developmental Psychobiology

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“…For Schenk (1985), on the other hand, 32-to 35-day-old animals can orientate using distal information. In learning on a radial maze, developmental studies show that young, recently weaned rats attain performances equivalent to adults (Olton & Schlosberg, 1978, Rauch & Raskin, 1984. However, in these studies, the authors used a nonconfinement procedure that revealed little about the type of information used by the subject to perform the task.…”

Section: Introductionmentioning

confidence: 99%

Ontogeny of orientation and spatial learning on the radial maze in mices

Chapillon

Lassalle

1995

Developmental Psychobiology

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The development of the orientation capacities of C57BL/6 mice has been studied on the radial maze in several procedures allowed to dissociate the different types of cues used by the mouse for solving the task with two intersession delays (2 and 24 hr). The results of the first two studies show that performance is independent of intersession delay regardless of the age of the subject. Mice as early as 23 days old obtain good performances when they can develop an algorithmic strategy or when they dispose of both proximal and distal cues during learning. At 37 days of age, however, mice can efficiently solve the radial maze task with distal cues alone. However, in the third experiment, 23-day-old mice were able to use distal cues for orientation at the end of the learning session if, at the onset, they also had access to proximal cues. These results suggest that, on weaning, mice use several types of information for task performance and that, as they mature, they turn more often to distal cues for orientation.

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“…The work of Rauch and Raskin (1984) has demonstrated the beneficial effects of juvenile training in preweanling rats. In this report, training on a spatial navigation task from p16 to p20 resulted in water maze performance that was significantly better than chance as well as significantly better than naïve animals.…”

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confidence: 99%

Effect of juvenile pretraining on adolescent structural hippocampal attributes as a substrate for enhanced spatial performance

Keeley¹,

Wartman²,

Häusler³

et al. 2010

Learn. Mem.

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Research has demonstrated that Long -Evans rats (LER) display superior mnemonic function over Wistar rats (WR). These differences are correlated with endogenous and input-dependent properties of the hippocampus. The present work sought to determine if juvenile pretraining might enhance hippocampal structural markers and if this would be associated with spatial processing improvements. Male and female WR and LER were either handled or trained on a water maze task from postnatal day 16 (p16) to p26 (pretraining). All animals were then trained on the task from p40 to p44 followed by immunohistochemical assessment of synaptophysin (to mark presynaptic terminals), MAP-2 (to mark dendrites), and the phosphorylated (activated) form of the extracellular signal-regulated kinase-1 (pERK1) in the hippocampus. From p19 to p20, LER (both male and female) showed a dramatic improvement in locating the hidden platform compared to their WR counterparts. On the first day of training at p40, all pretrained groups showed shorter latencies to locate the platform compared to groups without pretraining. Over the next 4 d, only pretrained male LER showed enhanced memory. Immunohistochemical analysis revealed fewer pERK1-labeled neurons in the CA3 hippocampal region in all pretrained groups and fewer pERK1-labeled neurons in the CA1 region of pretrained male LER. Pretrained male LER also showed more MAP-2 staining in CA1 and dentate gyrus regions. Synaptophysin staining revealed a pattern of axonal redistribution in the CA3 region in the pretrained groups. Results suggest a pattern of structural hippocampal alterations that may help to identify network malleability following pretraining protocols.

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Cholinergic mediation of spatial memory in the preweanling rat: Application of the radial arm maze paradigm.

Cited by 52 publications

References 23 publications

Long‐term retention of spatial navigation by preweanling rats

Long‐term retention of spatial navigation by preweanling rats

Ontogeny of orientation and spatial learning on the radial maze in mices

Effect of juvenile pretraining on adolescent structural hippocampal attributes as a substrate for enhanced spatial performance

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