Cholinergic modulation of olfactory pattern separation

Chapuis, Julie; Wilson, Donald A.

doi:10.1016/j.neulet.2013.04.015

Cited by 36 publications

(32 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The connections with the CxA are probably part of the connectivity with other structures of the olfactory system. The LEnt has recently been shown to modulate the activity in the Pir and, from a functional point of view, to be involved in fine odor discrimination (Chapuis and Wilson, 2013). The projections to the CxA may be similarly involved in modulating the activity in the olfactory amygdala.…”

Section: Discussionmentioning

confidence: 99%

“…The cholinergic afferents received by the basolateral amygdala in rats are involved in modulating learning and memory processes related to emotional paradigms (that is, involving the use of unconditioned stimuli with either aversive or appetitive value, McIntyre et al, 1998; Vazdarjanova and McGaugh, 1999). In the case of the Pir, the cholinergic input modulates odor discrimination learning by means of its synapses with intra-cortical association fibers (Chapuis and Wilson, 2013). Given the transitional nature of the CxA, its cholinergic inputs may be modulating olfactory learning and memory processes.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

et al. 2016

View full text Add to dashboard Cite

The transitional zone between the ventral part of the piriform cortex and the anterior cortical nucleus of the amygdala, named the cortex-amygdala transition zone (CxA), shows two differential features that allow its identification as a particular structure. First, it receives dense cholinergic and dopaminergic innervations as compared to the adjacent piriform cortex and amygdala, and second, it receives projections from the main and accessory olfactory bulbs. In this work we have studied the pattern of afferent and efferent projections of the CxA, which are mainly unknown, by using the retrograde tracer Fluorogold and the anterograde tracer biotinylated dextranamine. The results show that the CxA receives a relatively restricted set of intratelencephalic connections, originated mainly by the olfactory system and basal forebrain, with minor afferents from the amygdala. The only relevant extratelencephalic afference originates in the ventral tegmental area (VTA). The efferent projections of the CxA reciprocate the inputs from the piriform cortex and olfactory amygdala. In addition, the CxA projects densely to the basolateral amygdaloid nucleus and the olfactory tubercle. The extratelencephalic projections of the CxA are very scarce, and target mainly hypothalamic structures. The pattern of connections of the CxA suggests that it is indeed a transitional area between the piriform cortex and the cortical amygdala. Double labeling with choline acetyltransferase indicates that the afferent projection from the basal forebrain is the origin of its distinctive cholinergic innervation, and double labeling with dopamine transporter shows that the projection from the VTA is the source of dopaminergic innervation. These connectivity and neurochemical features, together with the fact that it receives vomeronasal in addition to olfactory information, suggest that the CxA may be involved in processing olfactory information endowed with relevant biological meaning, such as odors related to reproductive or defensive behaviors.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Thus, while spatial coding of mixture-evoked activity within the olfactory bulb did not discriminate configural mixtures from their components [42][43][44], piriform cortical neural ensembles have been demonstrated to rapidly process co-occurring odorants into distinct representations, different from the representations of their component parts [45]. This cortical representation of configural odour objects is experience-dependent, promotes odour discrimination, and can be impaired by disrupting normal synaptic plasticity selectively within the piriform cortex [46][47][48]. It is unclear whether the simultaneous elemental representation of the components apparent here is also dependent on the piriform cortex.…”

Section: Discussionmentioning

confidence: 99%

Neonatal representation of odour objects: distinct memories of the whole and its parts

et al. 2014

Self Cite

View full text Add to dashboard Cite

Extraction of relevant information from highly complex environments is a prerequisite to survival. Within odour mixtures, such information is contained in the odours of specific elements or in the mixture configuration perceived as a whole unique odour. For instance, an AB mixture of the element A (ethyl isobutyrate) and the element B (ethyl maltol) generates a configural AB percept in humans and apparently in another species, the rabbit. Here, we examined whether the memory of such a configuration is distinct from the memory of the individual odorants. Taking advantage of the newborn rabbit's ability to learn odour mixtures, we combined behavioural and pharmacological tools to specifically eliminate elemental memory of A and B after conditioning to the AB mixture and evaluate consequences on configural memory of AB. The amnesic treatment suppressed responsiveness to A and B but not to AB. Two other experiments confirmed the specific perception and particular memory of the AB mixture. These data demonstrate the existence of configurations in certain odour mixtures and their representation as unique objects: after learning, animals form a configural memory of these mixtures, which coexists with, but is relatively dissociated from, memory of their elements. This capability emerges very early in life.

show abstract

“…For example, spike rate and timing, as well as synaptic plasticity, are strongly influenced by local inhibitory interneurons (Bekkers and Suzuki, 2013) and neuromodulatory tone (Chapuis and Wilson, 2013; Linster et al, 1999). This issue will be revisited in section 3 on olfactory cortex and pathology.…”

Section: The Role Of the Olfactory Cortex In Odor Perceptionmentioning

confidence: 99%

Cortical Odor Processing in Health and Disease

Wilson

Sadrian

et al. 2014

Progress in Brain Research

Self Cite

View full text Add to dashboard Cite

The olfactory system has a rich cortical representation, including a large archicortical component present in most vertebrates, and in mammals neocortical components including the entorhinal and orbitofrontal cortices. Together, these cortical components contribute to normal odor perception and memory. They help transform the physicochemical features of volatile molecules inhaled or exhaled through the nose into the perception of odor objects with rich associative and hedonic aspects. This chapter focuses on how olfactory cortical areas contribute to odor perception and begins to explore why odor perception is so sensitive to disease and pathology. Odor perception is disrupted by a wide range of disorders including Alzheimer’s disease, Parkinson’s disease, schizophrenia, depression, autism, and early life exposure to toxins. This olfactory deficit often occurs despite maintained functioning in other sensory systems. Does the unusual network of olfactory cortical structures contribute to this sensitivity?

show abstract

Cholinergic modulation of olfactory pattern separation

Cited by 36 publications

References 27 publications

Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

Neonatal representation of odour objects: distinct memories of the whole and its parts

Cortical Odor Processing in Health and Disease

Contact Info

Product

Resources

About