Cholinium chloride as a weak salting-out agent to tune the biomolecules partition behavior in polymer-salt aqueous two-phase systems

Wojeicchowski, José Pedro; Farias, Fabiane Oliveira; Gonsalves, Rodrigo Thibes; Yamamoto, Carlos Itsuo; Igarashi‐Mafra, Luciana; Mafra, Marcos R.

doi:10.1016/j.fbp.2020.08.008

Cited by 12 publications

(1 citation statement)

References 40 publications

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“…To date, many researchers have tried to improve ATPS performance by developing novel ATPS (for example, ionic liquid-based ATPS − ) or by using adjuvants (such as adding surfactants, acetonitrile, or ionic liquids − into PEG/salt ATPS). It has been concluded that these two methods can help improve the extraction efficiency of ATPS under certain conditions, however, the selectivity of ATPS for the molecules with similar structures or properties is still limited; actually, so far, the selectivity of ATPS is far from satisfactory. − …”

Section: Introductionmentioning

confidence: 99%

Selectivity of PEG/Salt Aqueous Two-Phase System Enhanced by Surfactant@MWCNT Composites

Liu,

Cheng,

et al. 2024

Langmuir

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Aqueous two-phase systems (ATPS) are considered a new type of green separation system, but their low selectivity to target molecules limits their practical application. In this study, we used surfactant@MWCNT as an adjuvant to improve the selectivity of PEG/(NH 4 ) 2 SO 4 ATPS. The surfactants used include Triton X-100 (TX-100), Tween 80, sodium dodecyl sulfate (SDS), sodium dodecyl benzenesulfonate (SDBS), and bis(2-ethylhexyl)sulfosuccinate sodium salt (AOT). Nine aromatic compounds, including syringic acid, vanillin, tryptophan, phenylalanine, tyrosine, mandelic acid, theophylline, theobromine, and cephalexin, were selected as model extracts. The results showed that the use of the surfactant@MWCNT composite as an adjuvant significantly improved the selectivity of the ATPS toward syringic acid among the nine extracts. Moreover, the selectivity of the ATPS for syringic acid with the TX-100/MWCNT composite as the adjuvant is better than that with the Tween 80/MWCNT composite as the adjuvant, followed by that with the anionic surfactant/ MWCNT composite as the adjuvant. The enhanced selectivity of ATPS by the surfactant/MWCNT composite is ascribed to the spatial effect and the electrostatic and hydrophobic interactions between the extract and the surfactant adsorbed on the MWCNT.

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Section: Introductionmentioning

confidence: 99%

Selectivity of PEG/Salt Aqueous Two-Phase System Enhanced by Surfactant@MWCNT Composites

Liu,

Cheng,

et al. 2024

Langmuir

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Aqueous two‐phase systems in Latin America: perspective and future trends

Picó

Lima

Mussagy

et al. 2021

J of Chemical Tech & Biotech

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Aqueous two‐phase systems (ATPS) have been demonstrated to be a simple and robust worldwide applied bioprocessing technology. From high value microscopic to macroscopic biological molecules obtained from a wide broad of matrices, ATPS have shown a high efficiency capacity for their concentration, enrichment, recovery, and purification. Particularly in Latin America, four relevant countries have paved the way and played important leading roles in this transformation history. This perspective article aims to present a critical analysis of the practical evolution of the main implementations of ATPS in Argentina, Brazil, Chile, and Mexico. Special attention is given to novel applications of this biphasic bioprocess that are being explored to accomplish visionary therapeutic tasks for the healthcare, biotechnology, and pharmaceutical sectors, as well as other environmental purposes. © 2021 Society of Chemical Industry (SCI).

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Recent progress in the synthesis of all-aqueous two-phase droplets using microfluidic approaches

Daradmare

Lee

2022

Colloids and Surfaces B: Biointerfaces

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Cholinium chloride as a weak salting-out agent to tune the biomolecules partition behavior in polymer-salt aqueous two-phase systems

Cited by 12 publications

References 40 publications

Selectivity of PEG/Salt Aqueous Two-Phase System Enhanced by Surfactant@MWCNT Composites

Selectivity of PEG/Salt Aqueous Two-Phase System Enhanced by Surfactant@MWCNT Composites

Aqueous two‐phase systems in Latin America: perspective and future trends

Recent progress in the synthesis of all-aqueous two-phase droplets using microfluidic approaches

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