Chondroblastoma: MR Characteristics with Pathologic Correlation

Jee, Won Hee; Park, Yong Koo; McCauley, Thomas R.; Choi, Kyu-Hong; Ryu, Kyung Nam; Suh, Jin Suck; Suh, Kyung Jin; Cho, Jae Hyun; Lee, Jeong Hoon; Park, Sungha; Lee, Youn Soo; Ok, In Young; Kim, Jung Man

doi:10.1097/00004728-199909000-00016

Cited by 71 publications

(36 citation statements)

References 15 publications

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“…Some low signal intensities detected on T2-weighted images are associated with the volume of immature cartilaginous stroma and the cellularity of chondroblasts. On T2-weighted images, it is required to differentiate from enchondroma, osteochondroma, and well-differentiated osteosarcoma that show high signal intensities, clear cell chondrosarcoma shows characteristics similar to chondroblastomas and shows diverse signal intensities on T2-weighted images, and thus it may be difficult to differentiate from them (13). Histological results show relatively undifferentiated hypercellular tissues with round or polygonal cartilaginous interstitium, and histological results were identical regardless of metastasis (7).…”

Section: Discussionmentioning

confidence: 99%

A Case of Spine Origin Chondroblastoma Metastasis to Lung

et al. 2009

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Section: Discussionmentioning

confidence: 99%

A Case of Spine Origin Chondroblastoma Metastasis to Lung

et al. 2009

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“…Previous studies of the MRI appearance of chondroblastoma have demonstrated that it is frequently associated with bone marrow edema, periosteal and soft tissue reactions and varying signal intensity on T2-weighted sequences [6,7,8]. It seems doubtful whether the MRI criteria as described in previous case reports [9] allow a reliable differentiation between chondroblastoma and the histologically malignant clear cell chondrosarcoma, which requires a more extended surgical approach and has an overall poorer prognosis.…”

Section: Introductionmentioning

confidence: 98%

Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

Kaim¹,

Hügli²,

Bonél³

et al. 2001

Skeletal Radiol

117

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Objective: To analyze and compare the radiological and magnetic resonance imaging (MRI) appearances of chondroblastoma and clear cell chondrosarcoma with histopathological correlation. Design and patients: Twelve patients with histologically proven chondroblastoma and of another four patients with clear cell chondrosarcoma were investigated by radiographs and MRI (T1-, T2-weighted sequences, intravenous gadolinium application). Additionally, the clinical and radiologic data of seven cases of clear cell chondrosarcoma without available MRI were considered. The localization, calcification of tumor matrix, periosteal reaction, cortical bone and patterns of bone destruction were analyzed according to the Lodwick radiological grading system (LRGS). The signal intensity on T1-and T2-weighted sequences, characteristics of contrast enhancement, associated bone marrow edema, soft tissue reaction and joint involvement were evaluated. Histopathological specimens were available in all cases. Results: The age of patients with chondroblastoma (range 15-59 years, mean 22.3 years) was lower than that of those with clear cell chondrosarcoma (range 19-61 years, mean 36.6 years), and the lesions were smaller in the chondroblastoma group (range 1-4 cm, mean 2.3 cm) than in patients with clear cell chondrosarcoma (range 3-7.5 cm, mean 5.2 cm). The chondroblastomas were more confined to the epiphysis (10/12) than the clear cell chondrosarcomas. All chondroblastomas and clear cell chondrosarcomas except one were classified as grade 1A or 1B according to the LRGS; one clear cell chondrosarcoma was judged as grade 2. Signal intensity of the tumors on MRI was very heterogeneous in both groups. High signal intensity on T2-weighted MR images in chondroblastoma mostly corresponded to areas with aneurysmal bone cyst components and in clear cell chondrosarcoma to islands of hyaline cartilage. Contrast enhancement occurred in all tumors and tended to be more intense with clear cell chondrosarcoma. Chondroblastoma was more frequently associated with bone marrow edema (11/12), periosteal reaction (10/12), soft tissue reaction (7/12) and synovitis (3/12). Conclusion: Chondroblastoma occurs in younger patients, is smaller than clear cell chondrosarcoma and is more confined to the epiphysis. The overlap of signal intensity and contrast enhancement patterns does not allow a reliable differentiation of the two tumors by MRI. Chondroblastomas are typically associated with bone marrow edema, periosteal reaction and soft tissue reaction.

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“…(18) Magnetic resonance (MR) imaging of CB may help confirm radiographic diagnosis in certain patients. The features of CB on MR imaging include hypointense T2 signal in some portions of the lesions, (18)(19)(20)(21)(22)(23) adjacent bone marrow oedema and soft tissue oedema, periosteal reaction or periostitis, (18)(19)(20)(21)(22)(23)(24) and fluid-fluid level. (25) However, these MR imaging features have subsequently been reported in multiple types of osseous lesions (24,25) other than CB, resulting in decreased specificity of MR imaging for differential diagnosis of CB.…”

Section: Introductionmentioning

confidence: 99%

Radiological findings in 31 patients with chondroblastoma in tubular and non-tubular bones

Jaovisidha

Siriapisith²,

Chitrapazt³

et al. 2013

smedj

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INTRODUCTIONChondroblastoma (CB) is a rare, benign, cartilaginous lesion of the bones that accounts for less than 1% of primary bone tumours.(1,2) It typically develops from the epiphysis of skeletally immature patients. (3,4) Peak incidence of CB is seen in the second decade of life, (5,6) and has been reported to occur more frequently in men than in women. (5,(7)(8)(9)(10) Although CB has a predilection for tubular bones such as the humerus, femur, tibia and metatarsus, (7,11) it can also be found in non-tubular bones (NTBs) such as flat bones (i.e. skull, maxilla and pelvis) (7) and epiphysoid bones (i.e. trapezium, (12) cuboid, (13,14) talus (15,16) and patella (17) ).Multifocal benign CB has also been reported. METHODSThis study was approved by the ethics committee at the Ramathibodi Hospital, Bangkok, Thailand (ID-10-52-01). We retrospectively reviewed the medical records of all patients with pathologically proven CB at our hospital during a 37-year period . A total of 31 patients (16 men; 15 women)

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Chondroblastoma: MR Characteristics with Pathologic Correlation

Abstract: Chondroblastoma was found to show hypointense portions on T2-weighted images. Signal intensity on T1- and T2-weighted MR images in chondroblastoma was dependent on the amounts of histopathological components.

Cited by 71 publications

References 15 publications

A Case of Spine Origin Chondroblastoma Metastasis to Lung

A Case of Spine Origin Chondroblastoma Metastasis to Lung

Chondroblastoma and clear cell chondrosarcoma: radiological and MRI characteristics with histopathological correlation

Radiological findings in 31 patients with chondroblastoma in tubular and non-tubular bones

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