Chondroitin sulfate-functionalized 3D hierarchical flower-type mesoporous silica with a superior capacity for selective isolation of low density lipoprotein

Cao, Jian-Fang; Wang, Xu; Zhang, Yaoyao; Shu, Yang; Wang, Jianhua

doi:10.1016/j.aca.2019.12.075

Cited by 9 publications

(7 citation statements)

References 39 publications

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“…The average diameter size of these spherical particles was ~ 1 μm (Figure 1c). The varying intensity inside the nanospheres, shown by the TEM image, indicates the ultralow density of the POSSurea, measured at 0.11 g/cm 3 , which is even lower than organically modified mesopores with a density of 0.655 g/cm 3 (Cao et al, 2020). As shown in Figure 2a, the solid-state magic angle spinning (MAS) 29 Si-NMR spectrum of POSS-urea reveals only two species of silicon atoms, T 3 and T 2, with a ratio of 70:30, respectively.…”

Section: Experimental Characterisationsmentioning

confidence: 92%

Bispropylurea bridged polysilsesquioxane: A microporous MOF-like material for molecular recognition

et al. 2021

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Microporous organosilicas assembled from polysilsesquioxane (POSS) building blocks are promising materials that are yet to be explored in-depth. Here, we investigate the processing and molecular structure of bispropylurea bridged POSS (POSS-urea), synthesised through the acidic condensation of 1,3-bis(3-(triethoxysilyl)propyl)urea (BTPU). Experimentally, we show that POSS-urea has excellent functionality for molecular recognition toward acetonitrile with an adsorption level of 74 mmol/g, which compares favourably to MOFs and zeolites, with applications in volatile organic compounds (VOC). The acetonitrile adsorption capacity was 132-fold higher relative to adsorption capacity for toluene, which shows the pores are highly selective towards acetonitrile adsorption due to their size and arrangement. Theoretically, our tight-binding density functional and molecular dynamics calculations demonstrated that this BTPU based POSS is microporous with an irregular placement of the pores. Structural studies confirm maximal pore sizes of ~ 1 nm, with POSS cages possessing an approximate edge length of ~ 3.16 Å.

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Section: Experimental Characterisationsmentioning

confidence: 92%

Bispropylurea bridged polysilsesquioxane: A microporous MOF-like material for molecular recognition

et al. 2021

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“…Although both models offered promising results, the absence of osteoregeneration experiments in vivo makes these materials a mere design exercise, in which the presence of glycans is not completely justified. Apart from its use as a stabilizer, CS was also successfully employed as a functional coating able to interact with blood lipoproteins through a double effect: electrostatic interaction plus saccharide recognition [196]. Although these CS-modified dendritic MSNs permitted selectively binding and isolating low-density lipoproteins (LDL) for analytical purposes, the potential of such a nanosystem as a therapeutic agent is of enormous interest, as it may enable an interesting therapeutic effect against hypercholesterolemia and blood vessel atheromatosis.…”

Section: Delivery Of Glycan-based Biomoleculesmentioning

confidence: 99%

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Castillo

Lozano

2020

Pharmaceutics

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The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very different nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action. Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.

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“…The therapeutic efficiency of hemoperfusion depends mainly upon the binding capacity between LDL and the functional ligands of the adsorbent. To date, a range of LDL adsorption materials have been explored for the removal of LDL, such as amino acids, 12,13 cholesterols, [14][15][16] negatively changed small groups (sulfonate, 17 carboxyl, [18][19][20] and phosphate 21 ), carrageenan, 22 sodium alginate, 23 glycosaminoglycans (heparin [24][25][26] and chondroitin sulfate [27][28][29] ), etc. However, the removal of LDL is always accompanied by consumption of high-density lipoprotein (HDL) due to the similar structure and molecular properties of lipoproteins.…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic shell nanomagnetic adsorbents for selective and highly efficient capture of low-density lipoprotein from hyperlipidaemia serum

Jiang

et al. 2022

J. Mater. Chem. B

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Chondroitin sulfate-functionalized 3D hierarchical flower-type mesoporous silica with a superior capacity for selective isolation of low density lipoprotein

Cited by 9 publications

References 39 publications

Bispropylurea bridged polysilsesquioxane: A microporous MOF-like material for molecular recognition

Bispropylurea bridged polysilsesquioxane: A microporous MOF-like material for molecular recognition

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Amphiphilic shell nanomagnetic adsorbents for selective and highly efficient capture of low-density lipoprotein from hyperlipidaemia serum

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