Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance

Boehme, Karen A.; Schleicher, Sabine; Traub, Frank; Rolauffs, Bernd

doi:10.3390/ijms19010311

Cited by 64 publications

(63 citation statements)

References 217 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Proliferation of AC cells is modulated by fibroblast growth factor 2 (FGF2) [22,23] and transforming growth factor β (TGF-β) [24] signaling, in addition to many other effects. Therefore, particularly FGF2, TGF-β, and inflammatory cytokine signaling in combination with their miRNA regulation in human AC have been reviewed.…”

Section: Introductionmentioning

confidence: 99%

Onset and Progression of Human Osteoarthritis—Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?

Boehme,

Rolauffs

2018

IJMS

Self Cite

View full text Add to dashboard Cite

Osteoarthritis (OA) is a degenerative whole joint disease, for which no preventative or therapeutic biological interventions are available. This is likely due to the fact that OA pathogenesis includes several signaling pathways, whose interactions remain unclear, especially at disease onset. Early OA is characterized by three key events: a rarely considered early phase of proliferation of cartilage-resident cells, in contrast to well-established increased synthesis, and degradation of extracellular matrix components and inflammation, associated with OA progression. We focused on the question, which of these key events are regulated by growth factors, inflammatory cytokines, and/or miRNA abundance. Collectively, we elucidated a specific sequence of the OA key events that are described best as a very early phase of proliferation of human articular cartilage (AC) cells and concomitant anabolic/catabolic effects that are accompanied by incipient pro-inflammatory effects. Many of the reviewed factors appeared able to induce one or two key events. Only one factor, fibroblast growth factor 2 (FGF2), is capable of concomitantly inducing all key events. Moreover, AC cell proliferation cannot be induced and, in fact, is suppressed by inflammatory signaling, suggesting that inflammatory signaling cannot be the sole inductor of all early OA key events, especially at disease onset.

show abstract

Section: Introductionmentioning

confidence: 99%

Onset and Progression of Human Osteoarthritis—Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?

Boehme,

Rolauffs

2018

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is a malignant cartilage‐forming tumor that frequently occurs in the pelvis . CS mostly affects people in their 40s to 70s . Wide local excision has become the mainstay treatment because this tumor is highly resistant to chemotherapy and radiation .…”

mentioning

confidence: 99%

Can clinical radiomics nomogram based on 3D multiparametric MRI features and clinical characteristics estimate early recurrence of pelvic chondrosarcoma?

Yin

Mao

Liu

et al. 2019

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background Chondrosarcoma (CS) is the second most common primary malignant bone tumor, with a relatively high recurrence rate. However, an effective method that estimates whether pelvic CS will recur after surgery, which influences the formulation of a clinical treatment plan, remains lacking. Purpose To develop and validate a clinical radiomics nomograms based on 3D multiparametric magnetic resonance imaging (mpMRI) features and clinical characteristics that could estimate early recurrence (ER) (≤1 year) of pelvic CS. Study Type Retrospective. Population In all, 103 patients (ER = 41, non‐ER = 62) with histologically proven CS were retrospectively analyzed and divided into a training set (n = 72) and a validation set (n = 31). Field Strength/Sequence 3.0T axial T1‐weighted (T1‐w), T2‐weighted (T2‐w), diffusion weighted imaging (DWI), contrast‐enhanced T1‐weighted (CET1‐w). Assessment Risk factors (sex, age, type, grade, resection margins, etc.) associated with ER were evaluated. Five individual models based on T1‐w, T2‐w, DWI, CET1‐w, and clinical data were built. Then we compared the performance of models based on T1‐w, T2‐w, CET1‐w and their combination. Lastly, two nomograms based on the best model + clinical data and DWI + clinical data were built. Statistical Tests The area under the receiver operating characteristic curve (AUC) and accuracy (ACC) were used to evaluate different models. Results Grade was the most important univariate clinical predictor of ER of pelvic CS patients (odds ratio [OR]1 = 4.616, OR2 = 8.939, P < 0.05). T1‐w + T2‐w + CET1‐w had a significantly higher performance than CET1‐w in the training set (P = 0.01). Radiomics features are more important than clinical characteristics in clinical radiomics nomograms, especially for multisequence combined features (OR = 3.208, P < 0.01). Clinical radiomics nomogram based on combined features (T1‐w + T2‐w + CET1‐w) + clinical data achieved an AUC of 0.891 and ACC of 0.857, followed by DWI + clinical data (AUC = 0.882, ACC = 0.760) in the validation set. Data Conclusion The clinical radiomics nomogram had good performance in estimating ER of pelvic CS patients, which would be helpful in clinical decision‐making. Level of Evidence: 4 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:435–445.

show abstract

“…Chondrosarcomas are cartilaginous tumors, characterized by the production of hyaline cartilage [145,146]. Unlike Ewing and most osteosarcomas, these cartilage malignances are typically diagnosed in persons between 40 and 70 years of age [147]. Moreover, despite the advantages of DDS, since 2014 to the best of our knowledge none approach was developed to treat chondrosarcomas.…”

Section: Cancermentioning

confidence: 99%

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Lima

Ferreira

Reis

et al. 2019

Expert Opinion on Drug Delivery

View full text Add to dashboard Cite

Introduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice.

show abstract

Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance

Cited by 64 publications

References 217 publications

Onset and Progression of Human Osteoarthritis—Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?

Onset and Progression of Human Osteoarthritis—Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?

Can clinical radiomics nomogram based on 3D multiparametric MRI features and clinical characteristics estimate early recurrence of pelvic chondrosarcoma?

Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Contact Info

Product

Resources

About