Chondrosarcoma of bone

O’Neal, Lawrence W.; Ackerman, Lauren V.

doi:10.1002/1097-0142(195205)5:3<551::aid-cncr2820050317>3.0.co;2-z

Cited by 143 publications

(45 citation statements)

References 14 publications

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“…The histologic findings must be interpreted in view of clinical and radiographic features of the tumor [8] after studying its skeletal location and its local extension staging (Enneking stage). Grading is difficult for these tumors [8,20,23]. We believe open surgical biopsy is crucial before deciding on this conservative treatment [8], because it can provide sufficient material from several areas of the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Prior confirmation of Grade I chondrosarcoma by open surgical biopsy was required. Cytologic and histologic findings were used for tumor grading following the study of O'Neal and Ackerman [23]. Grade I chondrosarcoma has an increased cellularity compared with chondromas and chondrocytes have a slightly enlarged dense nucleus.…”

Section: Methodsmentioning

confidence: 99%

“…Grade I chondrosarcoma has an increased cellularity compared with chondromas and chondrocytes have a slightly enlarged dense nucleus. High cellularity and tissue-architectural features such as host bone entrapment and myxoid changes were useful to differentiate Grade I chondrosarcomas from chondromas [23]. Grade II chondrosarcomas are more cellular lesions with reduced calcification and more pronounced myxoid stroma.…”

Section: Methodsmentioning

confidence: 99%

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No Recurrences in Selected Patients after Curettage with Cryotherapy for Grade I Chondrosarcomas

Souna

Belot

Duval

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Background The low aggressiveness of Grade I chondrosarcomas is compatible with conservative surgical treatment. Questions/purpose We asked whether combined curettage and cryotherapy would yield low rates of recurrence and whether supplemental internal fixation would retain function with low rates of complications in patients with Grade I central chondrosarcomas of the proximal humerus or distal femur. Methods We retrospectively reviewed 15 patients: nine women and six men with a mean age of 45 years (range, 26-70 years). All patients underwent curettage and cryosurgery through a cortical window; we replaced the window and plated the region with at least three screws beyond the curetted area. None of the patients was lost to followup, and 14 patients (93%) were reexamined by us after a minimum of 5 years (mean, 8 years; range, 5-11 years). Results There were no perioperative anesthetic, neurologic, hardware, or healing complications. None of the patients had local recurrence or metastases develop. At last followup, the Musculoskeletal Tumor Society score was 27.9 (range, 22-30) and all patients had resumed their previous activities. No complications were associated with this simplified cryotherapy technique. Conclusions The data confirm the appropriateness of conservative surgery for central low-grade chondrosarcomas of the proximal humerus and distal femur based on a combination of intralesional curettage and cryogenic parietal sterilization. Candidates for this approach should be chosen on the basis of the affected bone site, local extension staging, and clinicopathologic grading. We recommend supplementary internal fixation.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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No Recurrences in Selected Patients after Curettage with Cryotherapy for Grade I Chondrosarcomas

Souna

Belot

Duval

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…Extralesional resection is achieved by using the zonal and sheath principles [16]. The tumour may be growing along the fascial sheath between muscles so that its bulk is increased by new tumour layers [2,15]. Consequently, the muscle sheath must be removed in a wide resection; if this is not possible the total zone of surrounding soft tissues must be removed in a radical excision [4].…”

Section: Discussionmentioning

confidence: 99%

Extralesional resection for tumours of the pelvic bones

Махсон¹

1997

International Orthopaedics

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“…Chondrosarcoma (CS), a heterogeneous subtype of malignant tumor derived from transformed cartilage cells, ranks as the second most common primary bone cancer next to osteosarcoma [1][2][3][4]. CS accounts for more than 20% of primary bone neoplasms [5].…”

mentioning

confidence: 99%

Aberrant DNA Methylations in Chondrosarcoma

Liu

Shen

et al. 2016

Epigenomics

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Chondrosarcoma (CS) is the second most common primary malignant bone tumor. Unlike other bone tumors, CS is highly resistant to conventional chemotherapy and radiotherapy, thus resulting in poor patient outcomes. There is an urgent need to establish alternative therapies for CS. However, the etiology and pathogenesis of CS still remain elusive. Recently, DNA methylation-associated epigenetic changes have been found to play a pivotal role in the initiation and development of human cancers, including CS, by regulating target gene expression in different cellular pathways. Elucidating the mechanisms of DNA methylation alteration may provide biomarkers for diagnosis and prognosis, as well as novel treatment options for CS. We have conducted a critical review to summarize the evidence regarding aberrant DNA methylation patterns as diagnostic biomarkers, predictors of progression and potential treatment strategies in CS.

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Chondrosarcoma of bone

Cited by 143 publications

References 14 publications

No Recurrences in Selected Patients after Curettage with Cryotherapy for Grade I Chondrosarcomas

No Recurrences in Selected Patients after Curettage with Cryotherapy for Grade I Chondrosarcomas

Extralesional resection for tumours of the pelvic bones

Aberrant DNA Methylations in Chondrosarcoma

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