Choosing the right cell for spinal cord repair

Zholudeva, Lyandysha V.; Lane, Megan

doi:10.1002/jnr.24351

Cited by 9 publications

(1 citation statement)

References 30 publications

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“…These changes can also refine and prune synaptic connections and promote the recruitment of other neurons (e.g., spinal interneurons) into the neural network ( Rank et al, 2015 ; Sandhu et al, 2015 ; Streeter et al, 2017 ). Spinal interneurons (SpINs) are a vital component of neuroplasticity ( Zholudeva and Lane, 2018 ; Zholudeva et al, 2021 ), that can change their pattern of activity and are reported to alter their connectivity to contribute to novel anatomical pathways. Most importantly, this neuroplastic potential can be therapeutically driven by either electrical stimulation or ABTs ( Harkema, 2008 ; van den Brand et al, 2012 ; Houle and Cote, 2013 ).…”

Section: Methods To Enhance Plasticitymentioning

confidence: 99%

Respiratory Training and Plasticity After Cervical Spinal Cord Injury

Randelman

Zholudeva

Vinit

et al. 2021

Front. Cell. Neurosci.

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While spinal cord injuries (SCIs) result in a vast array of functional deficits, many of which are life threatening, the majority of SCIs are anatomically incomplete. Spared neural pathways contribute to functional and anatomical neuroplasticity that can occur spontaneously, or can be harnessed using rehabilitative, electrophysiological, or pharmacological strategies. With a focus on respiratory networks that are affected by cervical level SCI, the present review summarizes how non-invasive respiratory treatments can be used to harness this neuroplastic potential and enhance long-term recovery. Specific attention is given to “respiratory training” strategies currently used clinically (e.g., strength training) and those being developed through pre-clinical and early clinical testing [e.g., intermittent chemical stimulation via altering inhaled oxygen (hypoxia) or carbon dioxide stimulation]. Consideration is also given to the effect of training on non-respiratory (e.g., locomotor) networks. This review highlights advances in this area of pre-clinical and translational research, with insight into future directions for enhancing plasticity and improving functional outcomes after SCI.

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