Chorda tympani nerve modulates the rat's avoidance of calcium chloride

Golden, Glen J.; Voznesenskaya, Anna; Tordoff, Michael G.

doi:10.1016/j.physbeh.2011.12.023

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…Behaviorally, NS neurons are required for Na + -K + discrimination [4] and for the detection of low-concentration Na + [14], [15]. On the other hand, behavioral evidence suggests that AG neurons are used to detect several cations [16], [17]. While AG and NS neurons use different molecular mechanisms, and have different functional roles, their different coding strategies are just beginning to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Statistical Analysis and Decoding of Neural Activity in the Rodent Geniculate Ganglion Using a Metric-Based Inference System

Mast

Ziembko

et al. 2013

PLoS ONE

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We analyzed the spike discharge patterns of two types of neurons in the rodent peripheral gustatory system, Na specialists (NS) and acid generalists (AG) to lingual stimulation with NaCl, acetic acid, and mixtures of the two stimuli. Previous computational investigations found that both spike rate and spike timing contribute to taste quality coding. These studies used commonly accepted computational methods, but they do not provide a consistent statistical evaluation of spike trains. In this paper, we adopted a new computational framework that treated each spike train as an individual data point for computing summary statistics such as mean and variance in the spike train space. We found that these statistical summaries properly characterized the firing patterns (e. g. template and variability) and quantified the differences between NS and AG neurons. The same framework was also used to assess the discrimination performance of NS and AG neurons and to remove spontaneous background activity or “noise” from the spike train responses. The results indicated that the new metric system provided the desired decoding performance and noise-removal improved stimulus classification accuracy, especially of neurons with high spontaneous rates. In summary, this new method naturally conducts statistical analysis and neural decoding under one consistent framework, and the results demonstrated that individual peripheral-gustatory neurons generate a unique and reliable firing pattern during sensory stimulation and that this pattern can be reliably decoded.

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Section: Introductionmentioning

confidence: 99%

Statistical Analysis and Decoding of Neural Activity in the Rodent Geniculate Ganglion Using a Metric-Based Inference System

Mast

Ziembko

et al. 2013

PLoS ONE

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Influence of cross-fostering on preference for calcium chloride in C57BL/6J and PWK/PhJ mice

Voznesenskaya

Tordoff

2013

Physiology & Behavior

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We investigated whether maternal influences during the suckling period alter the avidity for calcium, using as models mice from the calcium-preferring PWK/PhJ strain and the calcium-avoiding C57BL/6J strain. We found that milk collected from PWK/PhJ dams had higher calcium concentrations than did milk collected from C57BL/6J dams. Despite this, cross-strain fostering had no effect on adult calcium preferences relative to mice of the same strain that were within-strain fostered or not fostered. Our results indicate that calcium avoidance by C57BL/6J mice and acceptance by PWK/PhJ mice is unaffected by maternal environment during the suckling period.

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Vitamin C deficiency in osteogenic disorder Shionogi/Shi Jcl-od/od rats: effects on sour taste preferences, lick rates, chorda tympani nerve responses, and taste transduction elements

et al. 2023

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Animals use sour taste to avoid spoiled food and to choose foods containing vitamins and minerals. To investigate the response to sour taste substances during vitamin C (ascorbic acid; AA) deficiency, we conducted behavioral, neural, anatomical, and molecular biological experiments with Osteogenic Disorder Shionogi/Shi Jcl-od/od rats, which lack the ability to synthesize AA. Rats had higher 3 mM citric acid and 10 mM AA preference scores when AA-deficient than when replete. Licking rates for sour taste solutions [AA, citric acid, acetic acid, tartaric acid, and HCl] were significantly increased during AA deficiency relative to pre- and post-deficiency. Chorda tympani nerve recordings were conducted to evaluate organic acid taste responses in the AA-deficient and replete rats. Nerve responses to citric acid, acetic acid and tartaric acid were significantly diminished in AA-deficient rats relative to replete controls. There was no significant difference in the number of fungiform papillae taste buds per unit area in the AA-deficient rats relative to the replete rats. However, mRNA expression levels of Gnat3 (NM_173139.1), Trpm5 (NM_001191896.1), Tas1r1 (NM_053305.1), Car4 (NM_019174.3), and Gad1 (NM_017007.1) in fungiform papillae taste bud cells from AA-deficient rats were significantly lower than those in replete rats. Our data suggest that AA deficiency decreases avoidance of acids and reduces chorda tympani nerve responses to acids. AA deficiency down-regulates some taste-related genes in fungiform papillae taste bud cells. However, the results also reveal that the mRNA expression of some putative sour taste receptors in fungiform papillae taste bud cells is not affected by AA deficiency.

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Chorda tympani nerve modulates the rat's avoidance of calcium chloride

Cited by 4 publications

References 43 publications

Statistical Analysis and Decoding of Neural Activity in the Rodent Geniculate Ganglion Using a Metric-Based Inference System

Statistical Analysis and Decoding of Neural Activity in the Rodent Geniculate Ganglion Using a Metric-Based Inference System

Influence of cross-fostering on preference for calcium chloride in C57BL/6J and PWK/PhJ mice

Vitamin C deficiency in osteogenic disorder Shionogi/Shi Jcl-od/od rats: effects on sour taste preferences, lick rates, chorda tympani nerve responses, and taste transduction elements

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