Chorionic villus sampling experience of a reference perinatal medicine center

Beksaç, Mehmet Sinan; Ünal, Canan; Fadıloğlu, Erdem; Çakar, Ayşe Nur

doi:10.1111/ahg.12365

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…There was no increase in limb reduction defects, prematurity, low birth weight, fetal and neonatal mortality, and fetal distress in the chorionic villus sampling group in the two studies. [ 11 22 ] One of the cases developed club foot deformity in the present study. Due to sampling after 11 weeks gestation and the involvement of other factors, this anomaly does not seem to be related to placental sampling.…”

Section: Discussionmentioning

confidence: 50%

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Evaluation of Fetal and Maternal Outcomes in Chorion Villus Sampling (CVS)

Farahmand

Movahedi

Farahbod

et al. 2023

Advanced Biomedical Research

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Background: Chorionic villus sampling (CVS) is one of the invasive diagnostic methods used to diagnose chromosomal, genetic, and metabolic diseases in the embryonic period. The use of this method is associated with maternal and fetal consequences, the most serious of which is abortion. Therefore, the present study was conducted to investigate the incidence of these consequences and the factors affecting the incidence of abortion. Materials and Methods: A cross-sectional study was performed on 98 pregnant women with CVS indications. Maternal and fetal outcomes including abortion, vaginal bleeding, subchorionic hematoma, premature rupture of membrane (PROM), chorioamnionitis, preterm delivery, limb abnormality, fetal growth retardation, and preeclampsia were recorded. Results: The results of the present study showed that the incidence of fetal outcomes including fetal growth failure, premature rupture of membranes, abortion, and limb abnormalities was 4.1%, 7.1%, 3.1%, and 1%, and the incidence of maternal outcomes including preterm delivery, subchorionic hematoma, preeclampsia, and hemorrhage was 14.3%, 3.1%, 6.1%, and 10.2%, respectively. In addition, a decrease in free BHCG and an increase in NT were significantly associated with the occurrence of abortion (OR: 0.11 and 4.25, respectively, P value < 0.05). Conclusion: It should be noted that due to a long time between placental sampling and the occurrence of vaginal bleeding, premature rupture of membrane, and preterm delivery, it seems that placental sampling has no effect. In addition, only a decrease in free BHCG or an increase in NT significantly increased the chance of miscarriage.

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Section: Discussionmentioning

confidence: 50%

“…There was no increase in limb reduction defects, prematurity, low birth weight, fetal and neonatal mortality, and fetal distress in the chorionic villus sampling group. [ 11 22 ]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Fetal and Maternal Outcomes in Chorion Villus Sampling (CVS)

Farahmand

Movahedi

Farahbod

et al. 2023

Advanced Biomedical Research

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“…The previous obstetric history of the patients was also compared by BOI, which is "[number of living children + (π/10)]/gravida" [20]. This index is widely used for the comparison of high-risk pregnancies in the literature [14,21,22]. Additionally, miscarriage, FGR,"APGAR score < 7" at the first ten minutes, and NICU admission were defined as a composite adverse outcome.…”

Section: Methodsmentioning

confidence: 99%

Impact of Increased Activated Protein-C Resistance, Decreased Antithrombin III Activity and Hypocomplementemia on the Gestational Outcomes of Pregnancies with MTHFR Polymorphisms

Fadiloglu,

Donmez,

Beksac

et al. 2023

Z Geburtshilfe Neonatol

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Objective To evaluate the impact of increased Activated Protein C (APC) resistance, decreased antithrombin III activity and hypocomplementemia on the pregnancy outcomes of the patients with methylentetrahydrofolate reductase (MTHFR) polymorphisms. Methods This study was composed of 83 pregnancies with MTHFR polymorphisms. Increased APC resistance, decreased antithrombin III activity and hypocomplementemia were accepted as risk factors for poor gestational outcome. Results Having at least one risk factor resulted in significantly higher rates of “APGAR score of<7” at the first ten minutes (p=0.009). Composite adverse outcome rate was also higher in patients with at least one of the defined risk factors despite lack of statistical significance (p=0.241). Rate of newborn with an “APGAR score of<7” at first ten minutes was significantly higher at patients with hypocomplementemia (p=0.03). Conclusion Hypocomplementemia is a risk factor for poor gestational outcome in pregnancies with MTHFR polymorphisms.

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“…Наукові дослідження з морфометрії хоріальних ворсинок плаценти при передчасних пологах вказують на важливість вивчення структурних та геометричних характеристик плацентарної тканини для розуміння механізмів розвитку передчасних пологів та їхніх можливих наслідків для плода та матері. Однією з ключових характеристик, що досліджується в цьому контексті, є морфологія хоріальних ворсинок [1,2,3]. Проведені дослідження вказують на відмінності в морфометричних параметрах хоріальних ворсинок плаценти між нормальними та передчасними пологами.…”

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Morphometric Parameters of Maturity of Placental Chorinal Villi in Premature Labor

Tokar

2024

Buk. Med. Herald

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Aim – to establish some morphometric parameters of placental villi in premature birth in comparison with physiological pregnancy.Material and methods. The material (30 placentas in premature births and 30 placentas in physiological pregnancies) was fixed for 22-24 hours in a neutral buffered 10% formalin solution. Next, the material was dehydrated in an ascending battery of alcohols and embedded into paraffin at 580С. Serial histological sections 5 μm thick were made on a sled microtome. After deparaffinization, serial histological sections were stained with hematoxylin and eosin, and with a chromotrope - water blue according to N.Z.Slinchenko. In addition to the descriptive method of histopathological examination, computer morphometry was performed on previously obtained digital copies of optical microscopic images of the tissue (Delta Optical Evolution 100 microscope {planachromatic lenses according to the required optical magnification} and Olympus SP550UZ digital camera). Digital copies of the image were analyzed using a freeware copy of the ImageJ v1.52 computer program specialized for digital histometric studies. In particular, the percentage of different types of chorionic villi was calculated on digital copies of optical images using the unrepeatable score test method. The obtained digital data were processed statistically. In particular, with the help of a copy of the free (freeware) computer program for statistical calculations PAST v 4.14, a preliminary test for the normality of the distribution was applied according to the Wilkie-Hahn-Shapiro test. For all studied statistical samples, according to this criterion, the hypothesis about the normality of the distribution was not rejected (at p=0.05), therefore, parametric methods of statistical analysis were used: calculation of the arithmetic mean and its error, the odd two-sided Student's test. Along with the Student's test, the non-parametric Mann-Whitney U test was also used. Results. It was considered most important to start assessing the state of the placenta according to the percentage ratios between different types of villous formations. In particular, according to modern ideas about different types of chorionic villi in the II and III trimesters of pregnancy, the following types of villous formations of the placenta were distinguished: stem villi ("early" and late"), intermediate villi (immature and mature), terminal villi, terminal "specialized" villi, mesenchymal villi, embryonic villi, trophoblastic and villous processes. The total amount of the specified villi should be equal to 100%. The division of villi into primary, secondary, and tertiary villi is relevant only for the 1st trimester of pregnancy, therefore, it is not suitable for studying the morphological features of premature birth.Conclusions. According to the obtained morphometric data, the immaturity of the chorionic tree is noted in premature birth compared to physiological pregnancy. This can be seen from a noticeable increase in the percentage of stem "early" villi, intermediate immature and mature villi, mesenchymal and embryonic villi, trophoblastic and villous processes, but with a significant decrease in the percentage of terminal villi.

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Chorionic villus sampling experience of a reference perinatal medicine center

Cited by 3 publications

References 22 publications

Evaluation of Fetal and Maternal Outcomes in Chorion Villus Sampling (CVS)

Evaluation of Fetal and Maternal Outcomes in Chorion Villus Sampling (CVS)

Impact of Increased Activated Protein-C Resistance, Decreased Antithrombin III Activity and Hypocomplementemia on the Gestational Outcomes of Pregnancies with MTHFR Polymorphisms

Morphometric Parameters of Maturity of Placental Chorinal Villi in Premature Labor

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