Choroid morphometric analysis in non-neovascular age-related macular degeneration by means of optical coherence tomography angiography

Cicinelli, Maria Vittoria; Rabiolo, Alessandro; Marchese, Alessandro; Vitis, Luigi Antonio De; Carnevali, Adriano; Querques, Lea; Bandello, Francesco; Querques, Giuseppe

doi:10.1136/bjophthalmol-2016-309481

Cited by 78 publications

(56 citation statements)

References 34 publications

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“…Additionally, the percentage of nonperfused CC on OCTA correlated with visual acuity in RPD eyes. Similar results were reported by Cicinelli et al [41] by means of binarized OCTA scans. Chatziralli et al [42] additionally observed that one-third of patients with RPD also revealed CC flow impairment in areas outside of RPD affection.…”

Section: Octa In Dry Amdsupporting

confidence: 81%

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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The choriocapillaris (CC) represents a fundamentally important vascular layer that is subject to physiologic changes with increasing age and that is also associated with a wide range of chorioretinal diseases. So far, information on blood flow in this specific layer has remained limited. With the advent of optical coherence tomography angiography (OCTA), new perspectives and possibilities of CC imaging have begun to evolve. This article shall review the opportunities and challenges of applying OCTA technology to the CC layer and summarize the current clinical efforts in OCTA CC imaging exemplarily in dry age-related macular degeneration and central serous chorioretinopathy.

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Section: Octa In Dry Amdsupporting

confidence: 81%

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Lauermann¹,

Eter²,

Alten³

2018

Ophthalmologica

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“…OCT‐A has been extensively used in both non‐neovascular and exudative age‐related macular degeneration. In non‐neovascular age‐related macular degeneration, an increase in choriocapillaris flow voids was observed with increasing numbers of drusen and reticular pseudodrusen . In keeping with histology samples, pronounced choriocapillaris flow impairment is seen below geographic atrophy lesions .…”

Section: Applications In Retinal Diseasesupporting

confidence: 63%

Future clinical applicability of optical coherence tomography angiography

Chua

Tan

Ang

et al. 2019

Clinical and Experimental Optometry

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Optical coherence tomography angiography (OCT-A) is an emerging technology that allows for the non-invasive imaging of the ocular microvasculature. Despite the wealth of observations and numerous research studies illustrating the potential clinical uses of OCT-A, this technique is currently rarely used in routine clinical settings. In this review, technical and clinical aspects of OCT-A imaging are discussed, and the future clinical potential of OCT-A is considered. An understanding of the basic principles and limitations of OCT-A technology will better inform clinicians of its future potential in the diagnosis and management of ocular diseases.

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“…Cicinelli et al. () used OCT‐A to evaluate CC vascular density on binarized images in patients with drusen and RPD reporting decreased density in comparison with healthy controls. Chatziralli et al.…”

Section: Discussionmentioning

confidence: 99%

Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography

Vujosevic

Toma

Muraca

et al. 2019

Acta Ophthalmologica

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Purpose: To investigate choriocapillaris (CC) perfusion, by evaluating flow voids (FV), in eyes with intermediate age-related macular degeneration (iAMD) using swept-source optical coherence tomography angiography (SS-OCT-A). Methods: Patients with bilateral or unilateral iAMD and normal controls underwent SS-OCT and OCT-A examination. Choriocapillaris (CC) FVs were quantitatively assessed on OCT-A images using MATLAB (version 2017b; MathWorks, Natick, MA, USA), after a preprocessing aimed at compensating for CC attenuation artefacts. Three different thresholds [1 standard deviation (SD), 1.25 SD and 1.5 SD] were applied. Final FV percentage (FV%) was calculated as the ratio between area with absent flow and total scanned area. Results: Of 41 patients with iAMD and 16 normal subjects enrolled in the study, 39 eyes (39 patients) with iAMD and all 16 normal eyes (16 control subjects) were included in the final analysis. Mean FV% (1 SD) was 13.45 AE 0.66 in controls, 14.19 AE 1.23 in bilateral iAMD and 14.21 AE 0.99 in unilateral iAMD (p = 0.03, for difference between controls and bilateral iAMD). Mean FV% (1.25 SD) was 6.55 AE 0.65 in controls, 7.33 AE 1.4 in bilateral iAMD and 7.06 AE 1.4 in unilateral iAMD (p = 0.048, for difference between controls and bilateral iAMD). Mean FV% (1.5 SD) was 2.71 AE 0.82 in controls, 2.55 AE 1.12 in bilateral iAMD and 3.25 AE 1.17 in unilateral iAMD (p = 0.038, for difference between bilateral and unilateral iAMD). Conclusion: A significantly higher FV% was found in patients with iAMD versus controls. A higher trend in FV% was found in unilateral iAMD (with neovascular AMD in the fellow eye) versus bilateral iAMD, when applying the lowest threshold. Further, larger and longitudinal studies are needed to confirm this data.

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Choroid morphometric analysis in non-neovascular age-related macular degeneration by means of optical coherence tomography angiography

Abstract: Patients with non-neovascular AMD show significant choroidal vascular depletion and fibrotic replacement, suggesting a possible role in the pathogenesis and progression of the disease.

Cited by 78 publications

References 34 publications

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Optical Coherence Tomography Angiography Offers New Insights into Choriocapillaris Perfusion

Future clinical applicability of optical coherence tomography angiography

Quantitative choriocapillaris evaluation in intermediate age‐related macular degeneration by swept‐source optical coherence tomography angiography

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