Choroid plexus carcinoma with neuronal and glial differentiation in a 7-week-old male Sprague-Dawley rat

Abstract

We describe a case of choroid plexus carcinoma arising in the cerebrum of a 7-week-old male Sprague-Dawley rat. The tumor mass occupied the right lateral ventricle of the cerebrum. Histological analyses revealed that the epithelial tumor cells had proliferated in tubular, cribriform, papillary and solid growth patterns in the vicinity of the choroid plexus, with slight invasion into the cerebrum parenchyma. We divided the tumor cells into cuboidal, elongated and intermediate cells. Immunohistochemical studies showed that these tumor cells expressed relatively high levels of cytokeratin AE1/AE3, vimentin and glial fibrillary acidic proteins, and low levels of nestin, oligodendrocyte transcription factor and doublecortin proteins. The present case was diagnosed as a choroid plexus carcinoma with neuronal and glial differentiation.

Diagnosis of choroid plexus papilloma: Current perspectives and future directions

“…Although cytokeratins and vimentin are distinctive for CPPs, podoplanin expression is less specific in distinguishing CPP from other types of tumors, especially carcinomas. 28 , 29 Moreover, laminin, a type of adhesion glycoprotein of the basement membrane, could be more frequently detected in CPPs than in CPC and ependymomas, in which it is rarely detected. 30 …”