Choroid plexus volume predicts expansion of chronic lesions and brain atrophy

klistorner, Sasha; Klistorner, Samuel; Barnett, Michael; Wang, Chenyu; Graham, Stuart

doi:10.1101/2022.02.07.22270654

Cited by 2 publications

(2 citation statements)

References 53 publications

(83 reference statements)

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“…(Fleischer et al 2021) (Manouchehri and Stüve 2021) (V. A. Ricigliano et al 2021) (S. Klistorner et al 2022). We recently reported that volume of CP predicts subsequent expansion of chronic periventricular MS lesions and is associated tissue damage within and outside of chronic lesions.…”

Section: Discussionmentioning

confidence: 89%

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Choroid plexus volume is enlarged in clinically isolated syndrome patients with optic neuritis

Klistorner

Walt

Barnett

et al. 2022

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Objectives: People with Multiple Sclerosis (MS) have a larger choroid plexus (CP) volume than healthy controls. We investigated CP volume in early MS by quantitatively assessing brain MRI scans in patients presenting with optic neuritis (ON) as a clinically isolated syndrome (CIS), compared to a cohort with established Relapsing Remitting Multiple Sclerosis (RRMS) and healthy controls. Methods: Pre- and post-gadolinium 3D-T1, 3D FLAIR and diffusion tensor images were acquired from 44 CIS ON patients at baseline, 1, 3, 6 and 12 months after the onset of ON. Fifty RRMS patients and 50 healthy controls were also included for comparison. Results: ANOVA revealed significantly larger CP volumes in both ON CIS and RRMS groups compared to healthy controls (p<0.001 for both), but no difference between ON CIS and RRMS patients (p=0.9) Twenty-three ON CIS patients who converted to CDMS during 10 years of follow-up demonstrated CP volume similar to RRMS patients, but significantly larger compared to healthy controls (p<0.001). Increased CP volume was identified even in a sub-group of patients without MS-like lesions at baseline (p<0.001). A significant (~6%) transient increase of CP volume was observed following a new bout of inflammation, which, however, returned to pre-inflammatory state few months later. CP volume was not associated with the severity of acute inflammation of the optic nerve or long-term optic nerve axonal loss, not with brain lesion load or severity of tissue damage within lesions. Interpretation: Our data demonstrate that enlarged CP can be observe very early in a disease, transiently reacts to acute inflammation, but not associated with the degree of tissue destruction.

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Section: Discussionmentioning

confidence: 89%

“…Furthermore, the volume of the CP was linked to traditional measures of disease activity, including relapse rate and the number of enhancing lesions and expansion of chronic lesions (Fleischer et al 2021) (V. A. Ricigliano et al 2021) (Manouchehri and Stüve 2021) (S. Klistorner et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Choroid plexus volume is enlarged in clinically isolated syndrome patients with optic neuritis

Klistorner

Walt

Barnett

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

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Longitudinal enlargement of choroid plexus is associated with inflammation and neurodegeneration in RRMS patients

Klistorner

2023

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BackgroundThe Choroid Plexus (CP) plays a potential role in the initiation and propagation of neuroinflammatory processes in MS. However, the progressive change of the CP and its associations with biomarkers of acute and chronic inflammation, along with MS-related brain structure atrophy, have not been investigated.ObjectiveThis study aims to explore the longitudinal dynamics of the CP in RRMS patients and assess its relationship with inflammation and with atrophy in various brain compartments.Methods57 RRMS patients were examined annually for a minimum of 60 months using following MRI protocols: pre- and post-contrast (gadolinium) Sagittal 3D T1, FLAIR CUBE, diffusion weighted MRI. CP was manually segmented at baseline and last follow-up and normalised by head size. Annually lesion segmentation was performed by iQ-MSTM software suite and brain was segmented using AssemblyNet.ResultsOver the study period, the volume of CP increased by an average of 1.4% annually. The magnitude of CP enlargement significantly correlated with central brain atrophy, and to a lesser extent, total brain atrophy, white matter, and deep grey matter atrophy. Furthermore, progressive CP enlargement was significantly associated with the volume and severity of chronic lesion expansion (r=0.66, p<0.001), but not with the number or volume of new lesions.ConclusionOur findings indicate that ongoing inflammatory activity in the CP is linked to low-grade demyelination at the rim of chronic lesions and associated neurodegeneration of periventricular white and grey matter.

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Choroid plexus volume predicts expansion of chronic lesions and brain atrophy

Cited by 2 publications

References 53 publications

Choroid plexus volume is enlarged in clinically isolated syndrome patients with optic neuritis

Choroid plexus volume is enlarged in clinically isolated syndrome patients with optic neuritis

Longitudinal enlargement of choroid plexus is associated with inflammation and neurodegeneration in RRMS patients

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