Choroidal Blood-Flow Responses to Hyperoxia and Hypercapnia in Men with Obstructive Sleep Apnea

Tonini, M.; Khayi, H.; Pépin, Jean‐Louis; Renard, E; Baguet, Jean-Philippe; Lévy, Patrick; Romanet, Jean-Paul; Geiser, Martial; Chiquet, Christophe

doi:10.1093/sleep/33.6.811

Cited by 33 publications

(20 citation statements)

References 58 publications

(90 reference statements)

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“…They reported that all of the OSAS patients were newly diagnosed, and that the cause of the lack of deterioration in the choroidal flow may have been still intact autoregulatory mechanisms. Tonini et al 13 found similar choroidal blood flow reactivity to CO 2 and O 2 in the OSAS patients and controls in their prospective study, and concluded that ocular microcirculation, which provides adaptive mechanisms, continues long-term in OSAS patients. Contrarily, Xin et al 12 observed significantly lower measurements in severe OSAS patients with regard to the subfoveal and nasal choroidal thicknesses, when compared with the mild-moderate OSAS patients and control subjects.…”

Section: Discussionmentioning

confidence: 83%

“…Snoring is the most common symptom in 19,20 . Increased sympathetic system, endothelial, and autonomic dysfunctions have been shown in OSAS patients, and choroidal microcirculation, which is maintained by autonomic regulation, may be impaired as a result of one or more of these altered mechanisms 11,13 .…”

Section: Discussionmentioning

confidence: 99%

“…The choroid is one of the most highly vascularized tissues in humans, and due to OSAS, hypoxia, hypercapnia, impaired balance in the endothelial vasoactive substances, hemodynamic changes, and autonomic dysfunction may all cause impairment in the choroidal blood flow 11 . In previous studies, alterations in the choroidal thickness have been shown in adults with OSAS [11][12][13][14] . To the best of our knowledge, this is the first study to investigate the choroidal blood flow in the pediatric OSAS population.…”

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confidence: 85%

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Evaluation of choroidal thickness measurements in pediatric obstructive sleep apnea syndrome patients

Bayraktar

Şimşek

2017

Turk J Pediatr

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Choroidal vascular impairment and obstructive sleep apnea syndrome (OSAS) related disorders have been shown in adults, but there have been no investigations with regard to the choroidal thickness measurements in children with OSAS. Our aim was to investigate this relationship in the early childhood period, which correlates with OSAS peak incidence due to adenotonsillar enlargement. One-hundred and nine pediatric OSAS patients and 42 age-sex matched controls were enrolled in this study. Nocturnal pulse oximetry was used to define the OSAS patients. Demographic data like age, sex and body-mass index were recorded. All of the subjects underwent complete otolaryngologic and ophthalmologic examination including visual acuity, intraocular pressure, central corneal thickness, axial length and choroidal thickness measurements. Overall, the 1,000 µm and 1,500 µm nasal choroid measurements were found to be significantly lower in the patient group (p<0.05). However, only a poor inverse correlation emerged between the body-mass index (BMI) and the foveal center measurements in the patients. Observed alterations in the choroid may signify the initial impairment of known OSAS-related eye disorders, like glaucoma, floppy eyelid syndrome, and non-arteritic ischemic optic neuropathy. Ophthalmologists, otolaryngologists and pediatricians working together as a team may be able to prevent future eye diseases.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 85%

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Evaluation of choroidal thickness measurements in pediatric obstructive sleep apnea syndrome patients

Bayraktar

Şimşek

2017

Turk J Pediatr

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“…[30][31][32] Other studies have found unimpaired choroidal vascular reactivity in otherwise healthy men with obstructive sleep apnea. 33,34 Because other systemic comorbidities such as diabetes and hypertension exist in this population, further investigation of sleep apnea in PCV is required. Our data support querying PCV patients regarding a history of sleep-disordered breathing; those with positive symptoms or a history of sleep apnea should be referred for diagnostic sleep testing or sleep apnea management.…”

Section: Discussionmentioning

confidence: 99%

High-dose ranibizumab monotherapy for neovascular polypoidal choroidal vasculopathy in a predominantly non-Asian population

Marcus

Singh

Fechter

et al. 2015

Eye

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“…The measurement of CAVI has demonstrated good reproducibility and was not affected by the blood pressure during measurement 17,18) . To date, the majority of studies linking OSA to arterial stiffness recruited participants from sleep clinic patients [19][20][21] , there have been only two communitybased studies 22,23) , which also recruited patients with sleep disorder breathing and their methodology to measure arterial stiffness was different to CAVI.…”

Section: Assessment Of Nihmentioning

confidence: 99%

Relationships between Nocturnal Intermittent Hypoxia, Arterial Stiffness and Cardiovascular Risk Factors in a Community-based Population: The Toon Health Study

Alberto

Tanigawa

Maruyama

et al. 2014

JAT

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Aim: Nocturnal intermittent hypoxia (NIH), a primary marker of obstructive sleep apnea, has increasingly been linked with cardiovascular morbidity and mortality. The purpose of this study was to investigate the association between NIH and arterial stiffness as measured according to the cardio-ankle vascular index (CAVI) based on cardiovascular risk factors in a Japanese community-dwelling population. Methods: We conducted a cross-sectional study in Toon city among 684 men and 1,241 women 30-79 years of age. The severity of NIH was defined as mild or moderate-to-severe according to five or 15 events/hour on the 3% oxygen desaturation index (ODI), respectively. Increased arterial stiffness was diagnosed according to a CAVI of ≥ 9. Results: The number of subjects with no, mild and moderate-to-severe NIH was 1,348 (70%), 451 (23%) and 126 (7%), respectively. Increased arterial stiffness was detected in 21.9% of the participants. The multivariable-adjusted odds ratio (95% CI) of severe NIH related to an increased CAVI in comparison with a 3% ODI of ＜5 was 1.36 (0.82-2.23). The stratified logistic regression analysis showed that the multivariable-adjusted OR of severe NIH for an increased CAVI was remarkably increased in the individuals with a BMI of ≥ 25 (OR = 2.53, 1.08-5.96; p = 0.03). An interaction test showed a trend for an overweight status to be a modifier of the association between OSA and increased arterial stiffness (p = 0.05). Conclusions: NIH has a tendency to promote increased arterial stiffness as measured according to the CAVI, especially in overweight subjects.

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Choroidal Blood-Flow Responses to Hyperoxia and Hypercapnia in Men with Obstructive Sleep Apnea

Abstract: This study showed unimpaired choroidal vascular reactivity in otherwise healthy men with OSA. This suggests that patients with OSA, without comorbidities, have long-term adaptive mechanisms active in ocular microcirculation.

Cited by 33 publications

References 58 publications

Evaluation of choroidal thickness measurements in pediatric obstructive sleep apnea syndrome patients

Evaluation of choroidal thickness measurements in pediatric obstructive sleep apnea syndrome patients

High-dose ranibizumab monotherapy for neovascular polypoidal choroidal vasculopathy in a predominantly non-Asian population

Relationships between Nocturnal Intermittent Hypoxia, Arterial Stiffness and Cardiovascular Risk Factors in a Community-based Population: The Toon Health Study

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