Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized

Faghihi, Hooshang; Mahmoudi, Alireza; Pour, Elias Khalili; Ebrahimiadib, Nazanin; Fadakar, Kaveh; Ghassemi, Fariba; Mirshahi, Ahmad; Khodabande, Alireza; Khojasteh, Hassan; Bazvand, Fatemeh; Bahar, Mohammadreza Mehrabi; Riazi-Esfahani, Hamid

doi:10.1371/journal.pone.0257763

Cited by 14 publications

(16 citation statements)

References 37 publications

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“…However, in eyes with vFIPED, even after successful treatment with complete resolution of fluid, PED area remains unchanged. Higher reflectivity within PED in eyes with vFIPED, compared to aFIPED, indicate its vascular content 22 . Previous studies showed that vessel density and explant area do not change after successful treatment of PNV 23 .…”

Section: Discussionmentioning

confidence: 92%

Flat irregular pigment epithelial detachment over time and outcome of different treatment regimens

Ebrahimiadib

Bahar

Riazi-Esfahani

et al. 2022

Sci Rep

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To present long-term visual and structural outcome of treatment in two forms of flat irregular pigment epithelial detachment (FIPED): avascular (aFIPED) and vascularized (vFIPED) in eyes within pachychoroid spectrum. Prospective interventional case series. FIPED were classified into two subgroups; aFIPED and vFIPED based on OCTA. aFIPED underwent PDT, and vFIPED underwent either PDT, IVB, or combination of PDT&IVB. Vision, subretinal or intraretinal fluid, and choroidal biomarkers such as choroidal thickness, area, choroidal vascular index (CVI), and PED area were measured at baseline and last follow-up. Fifteen eyes with aFIPED were followed for a mean of 14.7 ± 10.8 months. Their vision improved, (0.44 ± 0.37–0.33 ± 0.40 LogMAR, p = 0.009) with significant reduction of fluid, choroidal area, thickness, PED area and increase in CVI. Twenty eyes with vFIPED were followed for a mean of 16.5 ± 8.2 months. The same pattern of choroidal alterations without visual improvement was observed in eyes underwent PDT alone. Combination therapy resulted in improvement of vision (0.38 ± 0.10–0.23 ± 0.17 LogMAR, p = 0.006) with reduction of choroidal area and thickness, with an increase in CVI. IVB alone could not change vision or choroidal structure. Single session PDT may lead to sustained visual improvement and structural change in eyes with aFIPED. Combination of PDT and IVB may be a better choice in eyes with vFIPED.

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Section: Discussionmentioning

confidence: 92%

Flat irregular pigment epithelial detachment over time and outcome of different treatment regimens

Ebrahimiadib

Bahar

Riazi-Esfahani

et al. 2022

Sci Rep

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“…CT, on the other hand, is a frequently used clinical research parameter that evaluates the entire choroidal vasculature without discriminating between the stromal and luminal vascular components. 26 Since 2014, few research has been conducted to explore different ways for analyzing choroidal architecture with a better distinction between lumen and stroma. Sonoda et al .…”

Section: Discussionmentioning

confidence: 99%

“…As a result, CVI measurement represents a more consistent biomarker for investigating choroidal changes. 25 , 26 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of Choroidal Vascularity Index in Keratoconus Patients: Does Choroidal Vascularity Change in Keratoconus?

Hashemian,

Ghafarian,

Riazi-Esfahani

et al. 2023

Journal of Current Ophthalmology

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Purpose:To investigate the choroidal structure in keratoconic patients with different severity using the choroidal vascularity index (CVI) derived from image binarization on enhanced depth imaging optical coherence tomography scans (EDI-OCT).Methods:Sixty-eight eyes from 34 keratoconus (KCN) patients and 72 eyes from 36 healthy subjects were recruited in this prospective, noninterventional, comparative cross-sectional study. EDI-OCT was employed to measure choroidal parameters, including choroidal thickness (CT), total choroidal area (TCA), luminal area, stromal area, and CVI.Results:Subfoveal CT was 354.6 ± 66.8 mm in the control group and 371 ± 64.5 mm in the KCN group (P= 0.86). There was no significant difference between control and KCN groups in terms of TCA (0.66 ± 0.14 mm2vs. 0.7 ± 0.12 mm2;P= 0.70), luminal area (0.49 ± 0.10 mm2vs. 0.53 ± 0.08 mm2;P= 0.67), and stromal area (0.16 ± 0.05 mm2vs. 0.17 ± 0.05 mm2;P= 0.84). CVI was also comparable in the control group (75.4% ±3.4%) and the KCN group (75.6% ±4.5%;P= 0.43). There was also no significant correlation between other choroidal parameters and KCN severity indices.Conclusion:It seems that CVI as well as other choroidal biomarkers were not significantly different between patients with KCN and healthy subjects.

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“…The inter-rater reliability of the CMT, SFCT, and CVI measurements was evaluated using the absolute agreement model of the interclass correlation coefficient on 20 EDI-OCT images, initially segmented by the 2 independent graders 15 .…”

Section: Methodsmentioning

confidence: 99%

Microvascular and structural analysis of the retina and choroid in heart failure patients with reduced ejection fraction

Khalilipur

Mahdizad

Molazadeh

et al. 2023

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This cross-sectional study was designed to assess alterations of choroidal and retinal microvasculature in patients with Heart Failure with Reduced Ejection Fraction (HFrEF) and compare them with a normal age and sex-matched population. Fifty-two eyes of 26 patients with HFrEF (left ventricular ejection fraction [LVEF] < 40%) and 64 eyes of 32 healthy individuals were considered as the patient and the control groups, respectively. We found no statistically significant differences in age-adjusted mean central macular thickness (CMT), superficial or deep retinal capillary plexus vascular densities, and choriocapillaris flow (CC flow) density between the HFrEF group and the normal controls, with the exception of the parafoveal mean superficial capillary plexus vascular density (P = 0.023), which remained statistically significant after adjusting for age (P = 0.034). The patients with HFrEF had a significantly lower subfoveal choroidal thickness (SFCT) than the normal subjects (264 ± 82 vs 313 ± 72; P = 0.009), and the difference was still statistically significant after age adjustment (P = 0.026). Although choroidal vascularity index (CVI) was lower in the HFrEF group than in the control group, the difference was not statistically significant before and after age adjustment (73.45 ± 6.67 vs 75.77 ± 5.92; P = 0.118 and P = 0.096, respectively). In conclusion, in patients with HFrEF, we observed a reduction in parafoveal retinal VD in the superficial capillary plexus, as well as SFCT, but no significant change in CVI, CMT, or CC flow density.

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Choroidal features in flat irregular pigment epithelial detachment associated with Chronic central serous chorioretinopathy: Avascular versus vascularized

Cited by 14 publications

References 37 publications

Flat irregular pigment epithelial detachment over time and outcome of different treatment regimens

Flat irregular pigment epithelial detachment over time and outcome of different treatment regimens

Evaluation of Choroidal Vascularity Index in Keratoconus Patients: Does Choroidal Vascularity Change in Keratoconus?

Microvascular and structural analysis of the retina and choroid in heart failure patients with reduced ejection fraction

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