Choroidal Thickness and Volume in a Healthy Pediatric Population and Its Relationship With Age, Axial Length, Ametropia, and Sex

Herrera, Laura; Pérez-Navarro, Itziar; Sánchez‐Cano, Ana; Pérez-García, Diana; Remón, Laura; Almenara, C.; Caramello, C; Cristobal, Ja; Pinilla, Isabel

doi:10.1097/iae.0000000000000636

Cited by 27 publications

(23 citation statements)

References 40 publications

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“…To the best of our knowledge, we are the first to demonstrate that the recovery of amblyopia had no significant effect on choroidal thickness. In our study, as in previous studies, choroidal thickness was significantly correlated with axial length. Therefore, it can be stated that the thickening of the choroid that has been found previously in the eyes with hyperopic anisometropic amblyopia may be an artefact of the correlation between choroidal thickness and hyperopia.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, Mori and colleagues speculated that choroidal accommodation might be inhibited with the diminutive visual feedback in the amblyopic eye; however, in all of these studies, amblyopic eyes were more hyperopic than the control eyes and it was not clear whether this choroidal thickening resulted from amblyopia or hyperopia. It has been demonstrated that there is a positive correlation between SE and choroidal thickness and a negative correlation between axial length and choroidal thickness . To the best of our knowledge, we are the first to demonstrate that the recovery of amblyopia had no significant effect on choroidal thickness.…”

Section: Discussionmentioning

confidence: 58%

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Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Öner

Bulut

2017

Clinical and Experimental Optometry

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 58%

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Öner

Bulut

2017

Clinical and Experimental Optometry

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“…Similar studies carried out on children have also revealed an inverse correlation between ChT and axial length (15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Original Research Articlementioning

confidence: 54%

Choroidal Thickness and Ametropia in Children: A Longitudinal Study

Fontaine

Gaucher

Sauer

et al. 2017

European Journal of Ophthalmology

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Purpose: To determine the relationship of subfoveal choroidal thickness (ChT), refraction, and axial length in children, and evaluate the evolution of subfoveal ChT with time in myopic versus nonmyopic eyes. Methods: A total of 229 eyes of 115 children aged 2 to 16 years were included in the study. Refraction under cycloplegia, axial length, and subfoveal ChT were measured at baseline with comparative investigations at 15 months follow-up. Results: The probability for the subfoveal ChT to be thinner in myopic children compared to nonmyopic children was 0.9999. We found a relation between subfoveal ChT and axial length. At 15 months follow-up, subfoveal ChT was found to have increased in the nonmyopic eyes, but decreased in myopic patients. Conclusions: A number of studies have already shown the choroid to play an important role in the process of emmetropization. We found that ChT had a different evolution in myopic children compared to nonmyopic children. A thinner choroid may predict the onset, or progression, of myopia. Further studies, with longer follow-up, are necessary to confirm this hypothesis.

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“…[4][5][6][7][8] In addition, it is known that ChT is affected by various factors such as blood pressure, age, gender, time of the day, refractive status, axial length, and forced hyperopic or myopic defocus. 2,[9][10][11] Further, a recent experimental study showed that anti-muscarinic agents could affect ChT. 12 Therefore, in the present study, we aimed to investigate the effects of tropicamide and cyclopentolate, which are two anti-muscarinic agents commonly used in the ophthalmologic practice, on subfoveal ChT measured by EDI OCT in healthy adults.…”

Section: Introductionmentioning

confidence: 99%

The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults

Öner

Bulut

Öter

2016

Eye

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Purpose To investigate the effects of tropicamide and cyclopentolate, which are two anti-muscarinic agents commonly used in the ophthalmologic practice, on subfoveal choroidal choroidal thickness (ChT) in healthy adults. Methods A total of 74 healthy adult subjects were enrolled in the study. Subjects were randomly divided into two groups: (1) cyclopentolate group (n = 37) in which the right eye (study eye) of each subject received topical cyclopentolate 1%, and the fellow eye (control eye) received artificial tears and (2) tropicamide group (n = 37) in which the right eye (study eye) of each subject received topical tropicamide 1% and the fellow eye (control eye) received artificial tears. Each topical medication was applied three times with 10-min intervals. ChT measurements were performed at baseline and 40 min after the last drops of the topical medications by enhanced depth imaging (EDI) optical coherence tomography (OCT). Results In the cyclopentolate group, subfoveal ChT significantly increased in the study eyes (P = 0.013), whereas it did not significantly change in the control eyes (P = 0.417). On the other hand, in the tropicamide group, no significant subfoveal ChT changes were observed in either the study eyes (P = 0.715) or the control eyes (P = 0.344). Conclusions The current study demonstrated that cyclopentolate caused significant choroidal thickening, whereas tropicamide had no significant effect on ChT in healthy adults. As a result, mydriasis by cyclopentolate may complicate ChT measurements by EDI OCT. Use of tropicamide may provide more reliable results for evaluation of ChT in ocular pathologies.

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Choroidal Thickness and Volume in a Healthy Pediatric Population and Its Relationship With Age, Axial Length, Ametropia, and Sex

Abstract: Healthy pediatric subjects exhibit choroidal differences in refractive error and AL. In the study population, CT and volume show an increase with age after adjusting for AL.

Cited by 27 publications

References 40 publications

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Choroidal Thickness and Ametropia in Children: A Longitudinal Study

The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults

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